MiR-205/YAP1 in Activated Fibroblasts of Breast Tumor Promotes VEGF-independent Angiogenesis through STAT3 Signaling

Tumor microenvironment contributes to tumor angiogenesis. However, the role of the activated cancer associated-fibroblasts (CAFs) in angiogenesis is still unclear. Here we report that miR-205/YAP1 signaling in the activated stromal fibroblasts plays a critical role in VEGF-independent angiogenesis i...

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Veröffentlicht in:	Theranostics 2017-01, Vol.7 (16), p.3972-3988
Hauptverfasser:	Du, Yan-E, Tu, Gang, Yang, Guanglun, Li, Genyou, Yang, Dan, Lang, Lei, Xi, Lei, Sun, Kexin, Chen, Yanlin, Shu, Kunxian, Liao, Huadong, Liu, Manran, Hou, Yixuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Breast Neoplasms - genetics Breast Neoplasms - metabolism Female Fibroblasts - metabolism Humans MicroRNAs - genetics MicroRNAs - metabolism Neovascularization, Pathologic - metabolism Phosphoproteins - genetics Phosphoproteins - metabolism Research Paper Signal Transduction - genetics Signal Transduction - physiology STAT3 Transcription Factor - metabolism Transcription Factors Vascular Endothelial Growth Factor A - metabolism
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