Adipose Tissue as a Strategic Source of Mesenchymal Stem Cells in Bone Regeneration: A Topical Review on the Most Promising Craniomaxillofacial Applications
Bone regeneration in craniomaxillofacial surgery represents an issue that involves both surgical and aesthetic aspects. The most recent studies on bone tissue engineering involving adipose-derived stromal/stem cells (ASCs) have clearly demonstrated that such cells can play a crucial role in the trea...
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| Veröffentlicht in: | International journal of molecular sciences 2017-10, Vol.18 (10), p.2140 |
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| creator | Paduano, Francesco Marrelli, Massimo Amantea, Massimiliano Rengo, Carlo Rengo, Sandro Goldberg, Michel Spagnuolo, Gianrico Tatullo, Marco |
| description | Bone regeneration in craniomaxillofacial surgery represents an issue that involves both surgical and aesthetic aspects. The most recent studies on bone tissue engineering involving adipose-derived stromal/stem cells (ASCs) have clearly demonstrated that such cells can play a crucial role in the treatment of craniomaxillofacial defects, given their strong commitment towards the osteogenic phenotype. A deeper knowledge of the molecular mechanisms underlying ASCs is crucial for a correct understanding of the potentialities of ASCs-based therapies in the most complex maxillofacial applications. In this topical review, we analyzed the molecular mechanisms of ASCs related to their support toward angiogenesis and osteogenesis, during bone regeneration. Moreover, we analyzed both case reports and clinical trials reporting the most promising clinical applications of ASCs in the treatment of craniomaxillofacial defects. Our study aimed to report the main molecular and clinical features shown by ASCs, used as a therapeutic support in bone engineering, as compared to the use of conventional autologous and allogeneic bone grafts. |
| doi_str_mv | 10.3390/ijms18102140 |
| format | Article |
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The most recent studies on bone tissue engineering involving adipose-derived stromal/stem cells (ASCs) have clearly demonstrated that such cells can play a crucial role in the treatment of craniomaxillofacial defects, given their strong commitment towards the osteogenic phenotype. A deeper knowledge of the molecular mechanisms underlying ASCs is crucial for a correct understanding of the potentialities of ASCs-based therapies in the most complex maxillofacial applications. In this topical review, we analyzed the molecular mechanisms of ASCs related to their support toward angiogenesis and osteogenesis, during bone regeneration. Moreover, we analyzed both case reports and clinical trials reporting the most promising clinical applications of ASCs in the treatment of craniomaxillofacial defects. 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The most recent studies on bone tissue engineering involving adipose-derived stromal/stem cells (ASCs) have clearly demonstrated that such cells can play a crucial role in the treatment of craniomaxillofacial defects, given their strong commitment towards the osteogenic phenotype. A deeper knowledge of the molecular mechanisms underlying ASCs is crucial for a correct understanding of the potentialities of ASCs-based therapies in the most complex maxillofacial applications. In this topical review, we analyzed the molecular mechanisms of ASCs related to their support toward angiogenesis and osteogenesis, during bone regeneration. Moreover, we analyzed both case reports and clinical trials reporting the most promising clinical applications of ASCs in the treatment of craniomaxillofacial defects. Our study aimed to report the main molecular and clinical features shown by ASCs, used as a therapeutic support in bone engineering, as compared to the use of conventional autologous and allogeneic bone grafts.</description><subject>Adipose tissue</subject><subject>Aesthetics</subject><subject>Angiogenesis</subject><subject>Autografts</subject><subject>Biocompatibility</subject><subject>Biomedical materials</subject><subject>Bone grafts</subject><subject>Bone growth</subject><subject>Bone surgery</subject><subject>Case reports</subject><subject>Clinical trials</subject><subject>Grafts</subject><subject>Maxillofacial</subject><subject>Medical research</subject><subject>Mesenchyme</subject><subject>Molecular modelling</subject><subject>Osteogenesis</subject><subject>Regeneration</subject><subject>Regeneration (physiology)</subject><subject>Review</subject><subject>Stem cells</subject><subject>Therapeutic applications</subject><subject>Tissue engineering</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpdkUtv1DAUhSMEoqWwY42uxIYFA7bjR8wCaRjxklqB2mFteZybGY8SO7WTQv8LPxZXLdXAyle63znyPaeqnlPypq41eev3Q6YNJYxy8qA6ppyxBSFSPTyYj6onOe8JYTUT-nF1xDRhSovmuPq9bP0YM8La5zwj2AwWLqZkJ9x6BxdxTg4hdnCGGYPbXQ-2L3scYIV9n8EH-BADwjluMWCR-RjewRLWcfSuoOd45fEnxADTDuEs5gm-pzj47MMWVskGHwf7y_d97KzzRbAcx74ob3zy0-pRZ_uMz-7ek-rHp4_r1ZfF6bfPX1fL04XjlE0Lp4QQVnDFpGItkY21lnK3UVy3lipZy40kzCnkrCOsawiV7UYRK7TWwom6Pqne3_qO82bA1mEoAfRmTH6w6dpE682_m-B3ZhuvjJBSNowVg1d3BilezpgnUy50JSAbMM7ZUC2okKUtUtCX_6H7knEo5xVKimLHNS_U61vKpZhzwu7-M5SYm9rNYe0Ff3F4wD38t-f6D2U1qnM</recordid><startdate>20171013</startdate><enddate>20171013</enddate><creator>Paduano, Francesco</creator><creator>Marrelli, Massimo</creator><creator>Amantea, Massimiliano</creator><creator>Rengo, Carlo</creator><creator>Rengo, Sandro</creator><creator>Goldberg, Michel</creator><creator>Spagnuolo, Gianrico</creator><creator>Tatullo, Marco</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-7340-0708</orcidid><orcidid>https://orcid.org/0000-0003-0916-8101</orcidid><orcidid>https://orcid.org/0000-0003-3769-9786</orcidid></search><sort><creationdate>20171013</creationdate><title>Adipose Tissue as a Strategic Source of Mesenchymal Stem Cells in Bone Regeneration: A Topical Review on the Most Promising Craniomaxillofacial Applications</title><author>Paduano, Francesco ; 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Our study aimed to report the main molecular and clinical features shown by ASCs, used as a therapeutic support in bone engineering, as compared to the use of conventional autologous and allogeneic bone grafts.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>29027958</pmid><doi>10.3390/ijms18102140</doi><orcidid>https://orcid.org/0000-0001-7340-0708</orcidid><orcidid>https://orcid.org/0000-0003-0916-8101</orcidid><orcidid>https://orcid.org/0000-0003-3769-9786</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adipose tissue Aesthetics Angiogenesis Autografts Biocompatibility Biomedical materials Bone grafts Bone growth Bone surgery Case reports Clinical trials Grafts Maxillofacial Medical research Mesenchyme Molecular modelling Osteogenesis Regeneration Regeneration (physiology) Review Stem cells Therapeutic applications Tissue engineering |
| title | Adipose Tissue as a Strategic Source of Mesenchymal Stem Cells in Bone Regeneration: A Topical Review on the Most Promising Craniomaxillofacial Applications |
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