Evolved Aztreonam Resistance Is Multifactorial and Can Produce Hypervirulence in Pseudomonas aeruginosa

While much attention has been focused on acquired antibiotic resistance genes, chromosomal mutations may be most important in chronic infections where isolated, persistently infecting lineages experience repeated antibiotic exposure. Here, we used experimental evolution and whole-genome sequencing t...

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Veröffentlicht in:	mBio 2017-10, Vol.8 (5)
Hauptverfasser:	Jorth, Peter, McLean, Kathryn, Ratjen, Anina, Secor, Patrick R, Bautista, Gilbert E, Ravishankar, Sumedha, Rezayat, Amir, Garudathri, Jayanthi, Harrison, Joe J, Harwood, Rachel A, Penewit, Kelsi, Waalkes, Adam, Singh, Pradeep K, Salipante, Stephen J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - pharmacology Aztreonam - pharmacology Chromosomes, Bacterial - genetics Chronic Disease Cystic Fibrosis - complications Cystic Fibrosis - microbiology Directed Molecular Evolution - methods Disease Models, Animal Drug Resistance, Multiple, Bacterial - genetics Evolution, Molecular Genetic Fitness Humans Membrane Transport Proteins Mice Microbial Sensitivity Tests Mutation Phenotype Pneumonia - microbiology Pseudomonas aeruginosa - drug effects Pseudomonas aeruginosa - genetics Pseudomonas aeruginosa - growth & development Pseudomonas aeruginosa - pathogenicity Pseudomonas Infections - microbiology Whole Genome Sequencing
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