Molecular alterations in colorectal adenomas and intramucosal adenocarcinomas defined by high-density single-nucleotide polymorphism arrays
Background We examined colorectal adenomas and intramucosal adenocarcinomas (IMAs) to develop a genome-wide overview of copy number alterations (CNAs) during colorectal tumorigenesis. Methods We analysed CNAs using a high-resolution SNP array of isolated tumour glands obtained from 55 colorectal ade...
Gespeichert in:
| Veröffentlicht in: | Journal of gastroenterology 2017-11, Vol.52 (11), p.1158-1168 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1168 |
|---|---|
| container_issue | 11 |
| container_start_page | 1158 |
| container_title | Journal of gastroenterology |
| container_volume | 52 |
| creator | Eizuka, Makoto Sugai, Tamotsu Habano, Wataru Uesugi, Noriyuki Takahashi, Yayoi Kawasaki, Keisuke Yamamoto, Eiichiro Suzuki, Hiromu Matsumoto, Takayuki |
| description | Background
We examined colorectal adenomas and intramucosal adenocarcinomas (IMAs) to develop a genome-wide overview of copy number alterations (CNAs) during colorectal tumorigenesis.
Methods
We analysed CNAs using a high-resolution SNP array of isolated tumour glands obtained from 55 colorectal adenomas (35 low-grade adenomas and 20 high-grade adenomas) and 30 IMAs. Next, we examined whether frequent CNAs differed between low-grade and high-grade adenomas or high-grade adenomas and IMAs. Finally, we investigated the total lengths of the CNAs in low-grade adenomas, high-grade adenomas, and IMAs.
Results
Although no frequent CNAs were found in low-grade adenomas, the most frequent alterations of high-grade adenomas were gains of 7q11, 7q21 and 9p13 and loss of 5q14.3-35. High levels of gains were detected at 13q, 7q, 8p, 20q, 7p, 18p and 17p in IMAs. Although no frequent alteration differed between low-grade and high-grade adenomas, significant differences of gains at 13q, 17p and 18p were found between high-grade adenoma and IMAs. Although the total lengths of all CNAs (gains and losses), copy number gains, and losses of heterozygosity were significantly greater in high-grade adenomas than in low-grade adenomas, no significant differences in the lengths of CNAs were found between high-grade adenomas and IMAs.
Conclusions
Genomic alterations play an essential role in early colorectal carcinogenesis. CNAs in colorectal tumours provide new insights for evaluation of colorectal tumorigenesis. |
| doi_str_mv | 10.1007/s00535-017-1317-2 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5666076</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A714583451</galeid><sourcerecordid>A714583451</sourcerecordid><originalsourceid>FETCH-LOGICAL-c561t-80f3ccc11adfbb100e49b5ce14de998575bac54303af934e63c414c44cef9c403</originalsourceid><addsrcrecordid>eNp1Ul1r1jAULqK41-kP8EYK3uymM6dN2uZGGMOpMPFGr0N6evq-GWnymrRCf4N_2pRucxMlkMB5PsJzeLLsNbBzYKx5FxkTlSgYNAVU6SqfZDvgaSJkWT7NdkxyXgA0_CR7EeMNY1Ax0T7PTsoWZNMyvst-ffGWcLY65NpOFPRkvIu5cTl66wPhpG2ue3J-1DHXrk_QFPQ4o493COqAZiP0NBhHfd4t-cHsD0WCo5mWPBq3t1S4GS35yfSUH71dRh-OBxPHXIegl_gyezZoG-nV7Xuafb_68O3yU3H99ePny4vrAkUNU9GyoUJEAN0PXZcWQVx2Agl4T1K2ohGdRsErVulBVpzqCjlw5BxpkMhZdZq933yPczdSj7QmsuoYzKjDorw26jHizEHt_U8l6rpmTZ0Mzm4Ngv8xU5zUaCKStdqRn6OCtm5rWTctJOrbv6g3fg4uxVMghQQBJRd_WHttSRk3-PQvrqbqogEu2oqL1ev8H6x0ehoNepd2n-aPBLAJMPgYAw33GYGptUFqa5BKDVJrg1SZNG8eLudecVeZRCg3QkyQ21N4kOi_rr8BNpvUkg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1959151245</pqid></control><display><type>article</type><title>Molecular alterations in colorectal adenomas and intramucosal adenocarcinomas defined by high-density single-nucleotide polymorphism arrays</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Eizuka, Makoto ; Sugai, Tamotsu ; Habano, Wataru ; Uesugi, Noriyuki ; Takahashi, Yayoi ; Kawasaki, Keisuke ; Yamamoto, Eiichiro ; Suzuki, Hiromu ; Matsumoto, Takayuki</creator><creatorcontrib>Eizuka, Makoto ; Sugai, Tamotsu ; Habano, Wataru ; Uesugi, Noriyuki ; Takahashi, Yayoi ; Kawasaki, Keisuke ; Yamamoto, Eiichiro ; Suzuki, Hiromu ; Matsumoto, Takayuki</creatorcontrib><description>Background
We examined colorectal adenomas and intramucosal adenocarcinomas (IMAs) to develop a genome-wide overview of copy number alterations (CNAs) during colorectal tumorigenesis.
Methods
We analysed CNAs using a high-resolution SNP array of isolated tumour glands obtained from 55 colorectal adenomas (35 low-grade adenomas and 20 high-grade adenomas) and 30 IMAs. Next, we examined whether frequent CNAs differed between low-grade and high-grade adenomas or high-grade adenomas and IMAs. Finally, we investigated the total lengths of the CNAs in low-grade adenomas, high-grade adenomas, and IMAs.
Results
Although no frequent CNAs were found in low-grade adenomas, the most frequent alterations of high-grade adenomas were gains of 7q11, 7q21 and 9p13 and loss of 5q14.3-35. High levels of gains were detected at 13q, 7q, 8p, 20q, 7p, 18p and 17p in IMAs. Although no frequent alteration differed between low-grade and high-grade adenomas, significant differences of gains at 13q, 17p and 18p were found between high-grade adenoma and IMAs. Although the total lengths of all CNAs (gains and losses), copy number gains, and losses of heterozygosity were significantly greater in high-grade adenomas than in low-grade adenomas, no significant differences in the lengths of CNAs were found between high-grade adenomas and IMAs.
Conclusions
Genomic alterations play an essential role in early colorectal carcinogenesis. CNAs in colorectal tumours provide new insights for evaluation of colorectal tumorigenesis.</description><identifier>ISSN: 0944-1174</identifier><identifier>EISSN: 1435-5922</identifier><identifier>DOI: 10.1007/s00535-017-1317-2</identifier><identifier>PMID: 28197804</identifier><language>eng</language><publisher>Tokyo: Springer Japan</publisher><subject>Abdominal Surgery ; Adenocarcinoma - genetics ; Adenocarcinoma - pathology ; Adenoma ; Adenoma - genetics ; Adenoma - pathology ; Adult ; Aged ; Aged, 80 and over ; Carcinogenesis ; Colorectal cancer ; Colorectal Neoplasms - genetics ; Colorectal Neoplasms - pathology ; Colorectal Surgery ; Copy number ; DNA Copy Number Variations - genetics ; Female ; Gastroenterology ; Genetic aspects ; Genome, Human ; Genomes ; Genomics ; Glands ; Hepatology ; Heterozygosity ; Humans ; Male ; Medical colleges ; Medicine ; Medicine & Public Health ; Middle Aged ; Neoplasm Grading ; Original Article—Alimentary Tract ; Original —Alimentary Tract ; Polymorphism ; Polymorphism, Single Nucleotide ; Single nucleotide polymorphisms ; Single-nucleotide polymorphism ; Surgical Oncology ; Tumorigenesis ; Tumors</subject><ispartof>Journal of gastroenterology, 2017-11, Vol.52 (11), p.1158-1168</ispartof><rights>The Author(s) 2017</rights><rights>COPYRIGHT 2017 Springer</rights><rights>Journal of Gastroenterology is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c561t-80f3ccc11adfbb100e49b5ce14de998575bac54303af934e63c414c44cef9c403</citedby><cites>FETCH-LOGICAL-c561t-80f3ccc11adfbb100e49b5ce14de998575bac54303af934e63c414c44cef9c403</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00535-017-1317-2$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00535-017-1317-2$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28197804$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Eizuka, Makoto</creatorcontrib><creatorcontrib>Sugai, Tamotsu</creatorcontrib><creatorcontrib>Habano, Wataru</creatorcontrib><creatorcontrib>Uesugi, Noriyuki</creatorcontrib><creatorcontrib>Takahashi, Yayoi</creatorcontrib><creatorcontrib>Kawasaki, Keisuke</creatorcontrib><creatorcontrib>Yamamoto, Eiichiro</creatorcontrib><creatorcontrib>Suzuki, Hiromu</creatorcontrib><creatorcontrib>Matsumoto, Takayuki</creatorcontrib><title>Molecular alterations in colorectal adenomas and intramucosal adenocarcinomas defined by high-density single-nucleotide polymorphism arrays</title><title>Journal of gastroenterology</title><addtitle>J Gastroenterol</addtitle><addtitle>J Gastroenterol</addtitle><description>Background
We examined colorectal adenomas and intramucosal adenocarcinomas (IMAs) to develop a genome-wide overview of copy number alterations (CNAs) during colorectal tumorigenesis.
Methods
We analysed CNAs using a high-resolution SNP array of isolated tumour glands obtained from 55 colorectal adenomas (35 low-grade adenomas and 20 high-grade adenomas) and 30 IMAs. Next, we examined whether frequent CNAs differed between low-grade and high-grade adenomas or high-grade adenomas and IMAs. Finally, we investigated the total lengths of the CNAs in low-grade adenomas, high-grade adenomas, and IMAs.
Results
Although no frequent CNAs were found in low-grade adenomas, the most frequent alterations of high-grade adenomas were gains of 7q11, 7q21 and 9p13 and loss of 5q14.3-35. High levels of gains were detected at 13q, 7q, 8p, 20q, 7p, 18p and 17p in IMAs. Although no frequent alteration differed between low-grade and high-grade adenomas, significant differences of gains at 13q, 17p and 18p were found between high-grade adenoma and IMAs. Although the total lengths of all CNAs (gains and losses), copy number gains, and losses of heterozygosity were significantly greater in high-grade adenomas than in low-grade adenomas, no significant differences in the lengths of CNAs were found between high-grade adenomas and IMAs.
Conclusions
Genomic alterations play an essential role in early colorectal carcinogenesis. CNAs in colorectal tumours provide new insights for evaluation of colorectal tumorigenesis.</description><subject>Abdominal Surgery</subject><subject>Adenocarcinoma - genetics</subject><subject>Adenocarcinoma - pathology</subject><subject>Adenoma</subject><subject>Adenoma - genetics</subject><subject>Adenoma - pathology</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Carcinogenesis</subject><subject>Colorectal cancer</subject><subject>Colorectal Neoplasms - genetics</subject><subject>Colorectal Neoplasms - pathology</subject><subject>Colorectal Surgery</subject><subject>Copy number</subject><subject>DNA Copy Number Variations - genetics</subject><subject>Female</subject><subject>Gastroenterology</subject><subject>Genetic aspects</subject><subject>Genome, Human</subject><subject>Genomes</subject><subject>Genomics</subject><subject>Glands</subject><subject>Hepatology</subject><subject>Heterozygosity</subject><subject>Humans</subject><subject>Male</subject><subject>Medical colleges</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neoplasm Grading</subject><subject>Original Article—Alimentary Tract</subject><subject>Original —Alimentary Tract</subject><subject>Polymorphism</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Single nucleotide polymorphisms</subject><subject>Single-nucleotide polymorphism</subject><subject>Surgical Oncology</subject><subject>Tumorigenesis</subject><subject>Tumors</subject><issn>0944-1174</issn><issn>1435-5922</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1Ul1r1jAULqK41-kP8EYK3uymM6dN2uZGGMOpMPFGr0N6evq-GWnymrRCf4N_2pRucxMlkMB5PsJzeLLsNbBzYKx5FxkTlSgYNAVU6SqfZDvgaSJkWT7NdkxyXgA0_CR7EeMNY1Ax0T7PTsoWZNMyvst-ffGWcLY65NpOFPRkvIu5cTl66wPhpG2ue3J-1DHXrk_QFPQ4o493COqAZiP0NBhHfd4t-cHsD0WCo5mWPBq3t1S4GS35yfSUH71dRh-OBxPHXIegl_gyezZoG-nV7Xuafb_68O3yU3H99ePny4vrAkUNU9GyoUJEAN0PXZcWQVx2Agl4T1K2ohGdRsErVulBVpzqCjlw5BxpkMhZdZq933yPczdSj7QmsuoYzKjDorw26jHizEHt_U8l6rpmTZ0Mzm4Ngv8xU5zUaCKStdqRn6OCtm5rWTctJOrbv6g3fg4uxVMghQQBJRd_WHttSRk3-PQvrqbqogEu2oqL1ev8H6x0ehoNepd2n-aPBLAJMPgYAw33GYGptUFqa5BKDVJrg1SZNG8eLudecVeZRCg3QkyQ21N4kOi_rr8BNpvUkg</recordid><startdate>20171101</startdate><enddate>20171101</enddate><creator>Eizuka, Makoto</creator><creator>Sugai, Tamotsu</creator><creator>Habano, Wataru</creator><creator>Uesugi, Noriyuki</creator><creator>Takahashi, Yayoi</creator><creator>Kawasaki, Keisuke</creator><creator>Yamamoto, Eiichiro</creator><creator>Suzuki, Hiromu</creator><creator>Matsumoto, Takayuki</creator><general>Springer Japan</general><general>Springer</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20171101</creationdate><title>Molecular alterations in colorectal adenomas and intramucosal adenocarcinomas defined by high-density single-nucleotide polymorphism arrays</title><author>Eizuka, Makoto ; Sugai, Tamotsu ; Habano, Wataru ; Uesugi, Noriyuki ; Takahashi, Yayoi ; Kawasaki, Keisuke ; Yamamoto, Eiichiro ; Suzuki, Hiromu ; Matsumoto, Takayuki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c561t-80f3ccc11adfbb100e49b5ce14de998575bac54303af934e63c414c44cef9c403</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Abdominal Surgery</topic><topic>Adenocarcinoma - genetics</topic><topic>Adenocarcinoma - pathology</topic><topic>Adenoma</topic><topic>Adenoma - genetics</topic><topic>Adenoma - pathology</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Carcinogenesis</topic><topic>Colorectal cancer</topic><topic>Colorectal Neoplasms - genetics</topic><topic>Colorectal Neoplasms - pathology</topic><topic>Colorectal Surgery</topic><topic>Copy number</topic><topic>DNA Copy Number Variations - genetics</topic><topic>Female</topic><topic>Gastroenterology</topic><topic>Genetic aspects</topic><topic>Genome, Human</topic><topic>Genomes</topic><topic>Genomics</topic><topic>Glands</topic><topic>Hepatology</topic><topic>Heterozygosity</topic><topic>Humans</topic><topic>Male</topic><topic>Medical colleges</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Neoplasm Grading</topic><topic>Original Article—Alimentary Tract</topic><topic>Original —Alimentary Tract</topic><topic>Polymorphism</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Single nucleotide polymorphisms</topic><topic>Single-nucleotide polymorphism</topic><topic>Surgical Oncology</topic><topic>Tumorigenesis</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Eizuka, Makoto</creatorcontrib><creatorcontrib>Sugai, Tamotsu</creatorcontrib><creatorcontrib>Habano, Wataru</creatorcontrib><creatorcontrib>Uesugi, Noriyuki</creatorcontrib><creatorcontrib>Takahashi, Yayoi</creatorcontrib><creatorcontrib>Kawasaki, Keisuke</creatorcontrib><creatorcontrib>Yamamoto, Eiichiro</creatorcontrib><creatorcontrib>Suzuki, Hiromu</creatorcontrib><creatorcontrib>Matsumoto, Takayuki</creatorcontrib><collection>Springer Nature OA/Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Eizuka, Makoto</au><au>Sugai, Tamotsu</au><au>Habano, Wataru</au><au>Uesugi, Noriyuki</au><au>Takahashi, Yayoi</au><au>Kawasaki, Keisuke</au><au>Yamamoto, Eiichiro</au><au>Suzuki, Hiromu</au><au>Matsumoto, Takayuki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Molecular alterations in colorectal adenomas and intramucosal adenocarcinomas defined by high-density single-nucleotide polymorphism arrays</atitle><jtitle>Journal of gastroenterology</jtitle><stitle>J Gastroenterol</stitle><addtitle>J Gastroenterol</addtitle><date>2017-11-01</date><risdate>2017</risdate><volume>52</volume><issue>11</issue><spage>1158</spage><epage>1168</epage><pages>1158-1168</pages><issn>0944-1174</issn><eissn>1435-5922</eissn><abstract>Background
We examined colorectal adenomas and intramucosal adenocarcinomas (IMAs) to develop a genome-wide overview of copy number alterations (CNAs) during colorectal tumorigenesis.
Methods
We analysed CNAs using a high-resolution SNP array of isolated tumour glands obtained from 55 colorectal adenomas (35 low-grade adenomas and 20 high-grade adenomas) and 30 IMAs. Next, we examined whether frequent CNAs differed between low-grade and high-grade adenomas or high-grade adenomas and IMAs. Finally, we investigated the total lengths of the CNAs in low-grade adenomas, high-grade adenomas, and IMAs.
Results
Although no frequent CNAs were found in low-grade adenomas, the most frequent alterations of high-grade adenomas were gains of 7q11, 7q21 and 9p13 and loss of 5q14.3-35. High levels of gains were detected at 13q, 7q, 8p, 20q, 7p, 18p and 17p in IMAs. Although no frequent alteration differed between low-grade and high-grade adenomas, significant differences of gains at 13q, 17p and 18p were found between high-grade adenoma and IMAs. Although the total lengths of all CNAs (gains and losses), copy number gains, and losses of heterozygosity were significantly greater in high-grade adenomas than in low-grade adenomas, no significant differences in the lengths of CNAs were found between high-grade adenomas and IMAs.
Conclusions
Genomic alterations play an essential role in early colorectal carcinogenesis. CNAs in colorectal tumours provide new insights for evaluation of colorectal tumorigenesis.</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>28197804</pmid><doi>10.1007/s00535-017-1317-2</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0944-1174 |
| ispartof | Journal of gastroenterology, 2017-11, Vol.52 (11), p.1158-1168 |
| issn | 0944-1174 1435-5922 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5666076 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Abdominal Surgery Adenocarcinoma - genetics Adenocarcinoma - pathology Adenoma Adenoma - genetics Adenoma - pathology Adult Aged Aged, 80 and over Carcinogenesis Colorectal cancer Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology Colorectal Surgery Copy number DNA Copy Number Variations - genetics Female Gastroenterology Genetic aspects Genome, Human Genomes Genomics Glands Hepatology Heterozygosity Humans Male Medical colleges Medicine Medicine & Public Health Middle Aged Neoplasm Grading Original Article—Alimentary Tract Original —Alimentary Tract Polymorphism Polymorphism, Single Nucleotide Single nucleotide polymorphisms Single-nucleotide polymorphism Surgical Oncology Tumorigenesis Tumors |
| title | Molecular alterations in colorectal adenomas and intramucosal adenocarcinomas defined by high-density single-nucleotide polymorphism arrays |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-26T18%3A30%3A16IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Molecular%20alterations%20in%20colorectal%20adenomas%20and%20intramucosal%20adenocarcinomas%20defined%20by%20high-density%20single-nucleotide%20polymorphism%20arrays&rft.jtitle=Journal%20of%20gastroenterology&rft.au=Eizuka,%20Makoto&rft.date=2017-11-01&rft.volume=52&rft.issue=11&rft.spage=1158&rft.epage=1168&rft.pages=1158-1168&rft.issn=0944-1174&rft.eissn=1435-5922&rft_id=info:doi/10.1007/s00535-017-1317-2&rft_dat=%3Cgale_pubme%3EA714583451%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1959151245&rft_id=info:pmid/28197804&rft_galeid=A714583451&rfr_iscdi=true |