Survivin: A novel marker and potential therapeutic target for human angiosarcoma

Human angiosarcoma is a rare malignant vascular tumor associated with extremely poor clinical outcome and generally arising in skin of the head and neck region. However, little is known about the molecular pathogeneses and useful immunohistochemical markers of angiosarcoma. To investigate the mechan...

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Veröffentlicht in:	Cancer science 2017-11, Vol.108 (11), p.2295-2305
Hauptverfasser:	Tsuneki, Masayuki, Kinjo, Takao, Mori, Taisuke, Yoshida, Akihiko, Kuyama, Kayo, Ohira, Aoi, Miyagi, Takuya, Takahashi, Kenzo, Kawai, Akira, Chuman, Hirokazu, Yamazaki, Naoya, Masuzawa, Mikio, Arakawa, Hirofumi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - genetics Adult Aged Aged, 80 and over Angiosarcoma Apoptosis - drug effects Biomarkers, Tumor - genetics Cancer Cell adhesion & migration Cell growth Cell Line, Tumor Cell proliferation Cell Proliferation - drug effects Cell Proliferation - genetics Female Gene amplification Gene Expression Regulation, Neoplastic - drug effects Granuloma Head and neck Hemangioma Hemangiosarcoma - genetics Hemangiosarcoma - pathology Hippo pathway Humans Imidazoles Inhibitor of Apoptosis Proteins - antagonists & inhibitors Inhibitor of Apoptosis Proteins - genetics Kinases Liver Localization Lymphocytes B Male Medical prognosis Metastasis Middle Aged Naphthoquinones Original Pathogenesis Phosphoproteins - genetics proliferation Protein-Serine-Threonine Kinases - genetics RNA-mediated interference Signal Transduction - genetics siRNA Skin Survivin Therapeutic applications Transcription Factors Transfection Tumors Yes-associated protein YM155
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