Oxidative Stress and Cellular Response to Doxorubicin: A Common Factor in the Complex Milieu of Anthracycline Cardiotoxicity

The production of reactive species is a core of the redox cycling profile of anthracyclines. However, these molecular characteristics can be viewed as a double-edged sword acting not only on neoplastic cells but also on multiple cellular targets throughout the body. This phenomenon translates into a...

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Veröffentlicht in:	Oxidative medicine and cellular longevity 2017-01, Vol.2017 (2017), p.1-13
Hauptverfasser:	Urbanek, Konrad, Naviglio, Silvio, Rossi, Francesco, Quaini, F., Illiano, Michela, Prezioso, Lucia, Sapio, Luigi, De Angelis, A., Cappetta, Donato, Berrino, L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anthracyclines - adverse effects Antibiotics, Antineoplastic - pharmacology Antibiotics, Antineoplastic - therapeutic use Cancer Cardiomyocytes Cardiomyopathy Cardiotoxicity - drug therapy Doxorubicin Doxorubicin - pharmacology Doxorubicin - therapeutic use Enzymes Humans Hydrogen peroxide Mitochondria Oxidative stress Oxidative Stress - drug effects Review Signal transduction Toxicity
Online-Zugang:	Volltext
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