Anatomical and Behavioral Investigation of C1ql3 in the Mouse Suprachiasmatic Nucleus
Many biochemical, physiological, and behavioral processes such as glucose metabolism, body temperature, and sleep-wake cycles show regular daily rhythms. These circadian rhythms are adjusted to the environmental light-dark cycle by a central pacemaker located in the suprachiasmatic nucleus (SCN) in...
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| Veröffentlicht in: | Journal of biological rhythms 2017-06, Vol.32 (3), p.222-236 |
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| creator | Chew, Kylie S. Fernandez, Diego C. Hattar, Samer Südhof, Thomas C. Martinelli, David C. |
| description | Many biochemical, physiological, and behavioral processes such as glucose metabolism, body temperature, and sleep-wake cycles show regular daily rhythms. These circadian rhythms are adjusted to the environmental light-dark cycle by a central pacemaker located in the suprachiasmatic nucleus (SCN) in order for the processes to occur at appropriate times of day. Here, we investigated the expression and function of a synaptic organizing protein, C1QL3, in the SCN. We found that C1ql3 is robustly expressed in the SCN. C1ql3 knockout mice have a reduced density of excitatory synapses in the SCN. In addition, these mice exhibited less consolidated activity to the active portions of the day and period lengthening following a 15-minute phase-delaying light pulse. These data identify C1QL3 as a signaling molecule that is highly expressed in SCN neurons, where it contributes to the formation and/or maintenance of glutamatergic synapses and plays a role in circadian behaviors, which may include circadian aftereffects. |
| doi_str_mv | 10.1177/0748730417704766 |
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These circadian rhythms are adjusted to the environmental light-dark cycle by a central pacemaker located in the suprachiasmatic nucleus (SCN) in order for the processes to occur at appropriate times of day. Here, we investigated the expression and function of a synaptic organizing protein, C1QL3, in the SCN. We found that C1ql3 is robustly expressed in the SCN. C1ql3 knockout mice have a reduced density of excitatory synapses in the SCN. In addition, these mice exhibited less consolidated activity to the active portions of the day and period lengthening following a 15-minute phase-delaying light pulse. These data identify C1QL3 as a signaling molecule that is highly expressed in SCN neurons, where it contributes to the formation and/or maintenance of glutamatergic synapses and plays a role in circadian behaviors, which may include circadian aftereffects.</description><identifier>ISSN: 0748-7304</identifier><identifier>EISSN: 1552-4531</identifier><identifier>DOI: 10.1177/0748730417704766</identifier><identifier>PMID: 28553739</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Animals ; Biochemistry ; Body temperature ; Circadian Rhythm ; Circadian rhythms ; Complement C1q - deficiency ; Complement C1q - genetics ; Complement C1q - metabolism ; Consolidation ; Glucose ; Glucose metabolism ; Glutamatergic transmission ; Light effects ; Maintenance ; Male ; Metabolism ; Mice ; Mice, Knockout ; Nerve Tissue Proteins - deficiency ; Nerve Tissue Proteins - genetics ; Nerve Tissue Proteins - metabolism ; Neurons ; Neurons - physiology ; Period Circadian Proteins - metabolism ; Photoperiod ; Physiology ; Rodents ; Signal Transduction ; Sleep ; Sleep and wakefulness ; Suprachiasmatic nucleus ; Suprachiasmatic Nucleus - physiology ; Synapses ; Synapses - physiology ; Temperature effects</subject><ispartof>Journal of biological rhythms, 2017-06, Vol.32 (3), p.222-236</ispartof><rights>2017 The Author(s)</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-cacfcb29773255cfa05c7124c7cce8d1af9dcaf8ba0b45fecb7effb2bf95e3773</citedby><cites>FETCH-LOGICAL-c420t-cacfcb29773255cfa05c7124c7cce8d1af9dcaf8ba0b45fecb7effb2bf95e3773</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/0748730417704766$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/0748730417704766$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>230,314,776,780,881,21798,27901,27902,43597,43598</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28553739$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chew, Kylie S.</creatorcontrib><creatorcontrib>Fernandez, Diego C.</creatorcontrib><creatorcontrib>Hattar, Samer</creatorcontrib><creatorcontrib>Südhof, Thomas C.</creatorcontrib><creatorcontrib>Martinelli, David C.</creatorcontrib><title>Anatomical and Behavioral Investigation of C1ql3 in the Mouse Suprachiasmatic Nucleus</title><title>Journal of biological rhythms</title><addtitle>J Biol Rhythms</addtitle><description>Many biochemical, physiological, and behavioral processes such as glucose metabolism, body temperature, and sleep-wake cycles show regular daily rhythms. These circadian rhythms are adjusted to the environmental light-dark cycle by a central pacemaker located in the suprachiasmatic nucleus (SCN) in order for the processes to occur at appropriate times of day. Here, we investigated the expression and function of a synaptic organizing protein, C1QL3, in the SCN. We found that C1ql3 is robustly expressed in the SCN. C1ql3 knockout mice have a reduced density of excitatory synapses in the SCN. In addition, these mice exhibited less consolidated activity to the active portions of the day and period lengthening following a 15-minute phase-delaying light pulse. These data identify C1QL3 as a signaling molecule that is highly expressed in SCN neurons, where it contributes to the formation and/or maintenance of glutamatergic synapses and plays a role in circadian behaviors, which may include circadian aftereffects.</description><subject>Animals</subject><subject>Biochemistry</subject><subject>Body temperature</subject><subject>Circadian Rhythm</subject><subject>Circadian rhythms</subject><subject>Complement C1q - deficiency</subject><subject>Complement C1q - genetics</subject><subject>Complement C1q - metabolism</subject><subject>Consolidation</subject><subject>Glucose</subject><subject>Glucose metabolism</subject><subject>Glutamatergic transmission</subject><subject>Light effects</subject><subject>Maintenance</subject><subject>Male</subject><subject>Metabolism</subject><subject>Mice</subject><subject>Mice, Knockout</subject><subject>Nerve Tissue Proteins - deficiency</subject><subject>Nerve Tissue Proteins - genetics</subject><subject>Nerve Tissue Proteins - metabolism</subject><subject>Neurons</subject><subject>Neurons - physiology</subject><subject>Period Circadian Proteins - metabolism</subject><subject>Photoperiod</subject><subject>Physiology</subject><subject>Rodents</subject><subject>Signal Transduction</subject><subject>Sleep</subject><subject>Sleep and wakefulness</subject><subject>Suprachiasmatic nucleus</subject><subject>Suprachiasmatic Nucleus - physiology</subject><subject>Synapses</subject><subject>Synapses - physiology</subject><subject>Temperature effects</subject><issn>0748-7304</issn><issn>1552-4531</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1UUtPAjEQboxGEL17Mk08r7bbdrt7MVHigwT1oJyb7tBCCWxhu0viv7cEJGjiaTr5HvN1BqFLSm4olfKWSJ5LRnh8Ey6z7Ah1qRBpwgWjx6i7gZMN3kFnIcwIIVnB2SnqpLkQTLKii0b3lW78woGeY12N8YOZ6rXzdWwH1dqExk1043yFvcV9upoz7CrcTA1-9W0w-KNd1hqmTodFpAF-a2Fu2nCOTqyeB3Oxqz00enr87L8kw_fnQf9-mABPSZOABgtlWkjJUiHAaiJA0pSDBDD5mGpbjEHbvNSk5MIaKKWxtkxLWwjDoqqH7ra-y7ZcmDGYqonJ1bJ2C11_Ka-d-o1Ubqomfq1ElsWl8WhwvTOo_aqN31Uz39ZVzKxoQUnOC8KKyCJbFtQ-hNrY_QRK1OYQ6u8houTqMNle8LP5SEi2hKAn5mDqf4bff2aSxw</recordid><startdate>20170601</startdate><enddate>20170601</enddate><creator>Chew, Kylie S.</creator><creator>Fernandez, Diego C.</creator><creator>Hattar, Samer</creator><creator>Südhof, Thomas C.</creator><creator>Martinelli, David C.</creator><general>SAGE Publications</general><general>SAGE PUBLICATIONS, INC</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>5PM</scope></search><sort><creationdate>20170601</creationdate><title>Anatomical and Behavioral Investigation of C1ql3 in the Mouse Suprachiasmatic Nucleus</title><author>Chew, Kylie S. ; 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These circadian rhythms are adjusted to the environmental light-dark cycle by a central pacemaker located in the suprachiasmatic nucleus (SCN) in order for the processes to occur at appropriate times of day. Here, we investigated the expression and function of a synaptic organizing protein, C1QL3, in the SCN. We found that C1ql3 is robustly expressed in the SCN. C1ql3 knockout mice have a reduced density of excitatory synapses in the SCN. In addition, these mice exhibited less consolidated activity to the active portions of the day and period lengthening following a 15-minute phase-delaying light pulse. 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| subjects | Animals Biochemistry Body temperature Circadian Rhythm Circadian rhythms Complement C1q - deficiency Complement C1q - genetics Complement C1q - metabolism Consolidation Glucose Glucose metabolism Glutamatergic transmission Light effects Maintenance Male Metabolism Mice Mice, Knockout Nerve Tissue Proteins - deficiency Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Neurons Neurons - physiology Period Circadian Proteins - metabolism Photoperiod Physiology Rodents Signal Transduction Sleep Sleep and wakefulness Suprachiasmatic nucleus Suprachiasmatic Nucleus - physiology Synapses Synapses - physiology Temperature effects |
| title | Anatomical and Behavioral Investigation of C1ql3 in the Mouse Suprachiasmatic Nucleus |
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