Mutations in the netrin-1 gene cause congenital mirror movements

Netrin-1 is a secreted protein that was first identified 20 years ago as an axon guidance molecule that regulates midline crossing in the CNS. It plays critical roles in various tissues throughout development and is implicated in tumorigenesis and inflammation in adulthood. Despite extensive studies...

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Veröffentlicht in:	The Journal of clinical investigation 2017-11, Vol.127 (11), p.3923-3936
Hauptverfasser:	Méneret, Aurélie, Franz, Elizabeth A, Trouillard, Oriane, Oliver, Thomas C, Zagar, Yvrick, Robertson, Stephen P, Welniarz, Quentin, Gardner, R J MacKinlay, Gallea, Cécile, Srour, Myriam, Depienne, Christel, Jasoni, Christine L, Dubacq, Caroline, Riant, Florence, Lamy, Jean-Charles, Morel, Marie-Pierre, Guérois, Raphael, Andreani, Jessica, Fouquet, Coralie, Doulazmi, Mohamed, Vidailhet, Marie, Rouleau, Guy A, Brice, Alexis, Chédotal, Alain, Dusart, Isabelle, Roze, Emmanuel, Markie, David
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged, 80 and over Alzheimer's disease Amino Acid Sequence Anatomy Animals Axon guidance Biomedical research Cancer Care and treatment Cell migration Central nervous system Congenital diseases Conserved Sequence Diagnosis Electromyography Female Gene Frequency Gene mutation Genes Genetic Association Studies HEK293 Cells HeLa Cells Heterozygote Humans Intracellular Life Sciences Localization Male Mice Movement disorders Movement Disorders - genetics Mutation Mutation, Missense Netrin-1 Netrin-1 - genetics Pedigree Proteins Pyramidal tracts Sequence Deletion Tumorigenesis Wavelet transforms
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