Selective Targeting of Bromodomains of the Bromodomain-PHD Fingers Family Impairs Osteoclast Differentiation

Histone acetyltransferases of the MYST family are recruited to chromatin by BRPF scaffolding proteins. We explored functional consequences and the therapeutic potential of inhibitors targeting acetyl-lysine dependent protein interaction domains (bromodomains) present in BRPF1–3 in bone maintenance....

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Veröffentlicht in:	ACS chemical biology 2017-10, Vol.12 (10), p.2619-2630
Hauptverfasser:	Meier, Julia C, Tallant, Cynthia, Fedorov, Oleg, Witwicka, Hanna, Hwang, Sung-Yong, van Stiphout, Ruud G, Lambert, Jean-Philippe, Rogers, Catherine, Yapp, Clarence, Gerstenberger, Brian S, Fedele, Vita, Savitsky, Pavel, Heidenreich, David, Daniels, Danette L, Owen, Dafydd R, Fish, Paul V, Igoe, Niall M, Bayle, Elliott D, Haendler, Bernard, Oppermann, Udo C.T, Buffa, Francesca, Brennan, Paul E, Müller, Susanne, Gingras, Anne Claude, Odgren, Paul R, Birnbaum, Mark J, Knapp, Stefan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone Marrow Cells - physiology Carrier Proteins - genetics Carrier Proteins - metabolism Cell Differentiation - physiology Computational Biology Humans Models, Molecular Multigene Family Osteoclasts - physiology Protein Array Analysis Protein Conformation Protein Domains Stem Cells
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