MnTBAP Inhibits Bleomycin‐Induced Pulmonary Fibrosis by Regulating VEGF and Wnt Signaling

Cellular oxidative stress is implicated not only in lung injury but also in contributing to the development of pulmonary fibrosis. We demonstrate that a cell‐permeable superoxide dismutase (SOD) mimetic and peroxynitrite scavenger, manganese (III) tetrakis (4‐benzoic acid) porphyrin chloride (MnTBAP...

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Veröffentlicht in:	Journal of cellular physiology 2017-03, Vol.232 (3), p.506-516
Hauptverfasser:	Venkatadri, Rajkumar, Iyer, Anand Krishnan V., Ramesh, Vani, Wright, Clayton, Castro, Carlos A., Yakisich, Juan S., Azad, Neelam
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Benzoic acid Biomarkers - metabolism Bleomycin Calcium Signaling - drug effects Calcium signalling Cell Line Chlorides Crosstalk Fibrosis Humans In vitro methods and tests In vivo methods and tests Interferon Lung diseases Manganese Metalloporphyrins - pharmacology Metalloporphyrins - therapeutic use Mice, Inbred C57BL Neovascularization, Physiologic - drug effects Oxidative stress Peroxynitrite Pulmonary fibrosis Pulmonary Fibrosis - chemically induced Pulmonary Fibrosis - drug therapy Pulmonary Fibrosis - metabolism Pulmonary Fibrosis - pathology Signal transduction Superoxide dismutase Up-Regulation - drug effects Upstream Vascular endothelial growth factor Vascular Endothelial Growth Factor A - metabolism Wnt protein Wnt Signaling Pathway - drug effects
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