Clomiphene citrate affects the receptivity of the uterine endometrium
Purpose To investigate whether clomiphene citrate (CC) affects uterine receptivity or not, we evaluated pregnancy rates (PR) during the hormone replacement cycle (HRC) according to the period between the last day of CC administration and the day of embryo transfer (ET). Methods From March 2008 throu...
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| Veröffentlicht in: | Reproductive medicine and biology 2015-04, Vol.14 (2), p.73-78 |
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| creator | Nakagawa, Koji Kaneyama, Masayo Nishi, Yayoi Sugiyama, Rie Motoyama, Hiroshi Sugiyama, Rikikazu |
| description | Purpose
To investigate whether clomiphene citrate (CC) affects uterine receptivity or not, we evaluated pregnancy rates (PR) during the hormone replacement cycle (HRC) according to the period between the last day of CC administration and the day of embryo transfer (ET).
Methods
From March 2008 through March 2010, a total of 378 treatment cycles among 378 patients who received CC and had to avoid fresh ET due to a thin uterine endometrium were recruited. All patients underwent thawed ET using HRC. PRs were evaluated according to the period between the last CC treatment and the day of ET.
Results
PR for the groups in which the period between the last CC treatment and the day of ET increased to more than 91 days were significantly higher than that for group in which the period was less than 90 days (
p
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| doi_str_mv | 10.1007/s12522-014-0195-z |
| format | Article |
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To investigate whether clomiphene citrate (CC) affects uterine receptivity or not, we evaluated pregnancy rates (PR) during the hormone replacement cycle (HRC) according to the period between the last day of CC administration and the day of embryo transfer (ET).
Methods
From March 2008 through March 2010, a total of 378 treatment cycles among 378 patients who received CC and had to avoid fresh ET due to a thin uterine endometrium were recruited. All patients underwent thawed ET using HRC. PRs were evaluated according to the period between the last CC treatment and the day of ET.
Results
PR for the groups in which the period between the last CC treatment and the day of ET increased to more than 91 days were significantly higher than that for group in which the period was less than 90 days (
p
< 0.05).
Conclusions
A lower PR was shown by the patients who underwent thawed ET in the HRC within 90 days after their last CC treatment, which shows that CC affects the receptivity of the uterine endometrium.</description><identifier>ISSN: 1445-5781</identifier><identifier>EISSN: 1447-0578</identifier><identifier>DOI: 10.1007/s12522-014-0195-z</identifier><identifier>PMID: 29259405</identifier><language>eng</language><publisher>Tokyo: Springer Japan</publisher><subject>Clomiphene ; Clomiphene citrate ; Embryo transfer ; Embryos ; Endocrinology ; Endometrium ; Gynecology ; Hormone replacement cycle ; Infertility ; Medicine ; Medicine & Public Health ; Original ; Original Article ; Ovaries ; Pregnancy rate ; Reproductive Medicine ; Thawed embryo transfer ; Thin uterine endometrium ; Urology ; Uterus</subject><ispartof>Reproductive medicine and biology, 2015-04, Vol.14 (2), p.73-78</ispartof><rights>Japan Society for Reproductive Medicine 2014</rights><rights>The Japan Society for Reproductive Medicine</rights><rights>2015. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4575-17b1c89f8cd6be20a123fec817379d9eee4d446e1d119a12be2dd10801c38f083</citedby><cites>FETCH-LOGICAL-c4575-17b1c89f8cd6be20a123fec817379d9eee4d446e1d119a12be2dd10801c38f083</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5661763/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5661763/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,860,881,1411,11541,27901,27902,45550,45551,46027,46451,53766,53768</link.rule.ids><linktorsrc>$$Uhttps://onlinelibrary.wiley.com/doi/abs/10.1007%2Fs12522-014-0195-z$$EView_record_in_Wiley-Blackwell$$FView_record_in_$$GWiley-Blackwell</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29259405$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nakagawa, Koji</creatorcontrib><creatorcontrib>Kaneyama, Masayo</creatorcontrib><creatorcontrib>Nishi, Yayoi</creatorcontrib><creatorcontrib>Sugiyama, Rie</creatorcontrib><creatorcontrib>Motoyama, Hiroshi</creatorcontrib><creatorcontrib>Sugiyama, Rikikazu</creatorcontrib><title>Clomiphene citrate affects the receptivity of the uterine endometrium</title><title>Reproductive medicine and biology</title><addtitle>Reprod Med Biol</addtitle><addtitle>Reprod Med Biol</addtitle><description>Purpose
To investigate whether clomiphene citrate (CC) affects uterine receptivity or not, we evaluated pregnancy rates (PR) during the hormone replacement cycle (HRC) according to the period between the last day of CC administration and the day of embryo transfer (ET).
Methods
From March 2008 through March 2010, a total of 378 treatment cycles among 378 patients who received CC and had to avoid fresh ET due to a thin uterine endometrium were recruited. All patients underwent thawed ET using HRC. PRs were evaluated according to the period between the last CC treatment and the day of ET.
Results
PR for the groups in which the period between the last CC treatment and the day of ET increased to more than 91 days were significantly higher than that for group in which the period was less than 90 days (
p
< 0.05).
Conclusions
A lower PR was shown by the patients who underwent thawed ET in the HRC within 90 days after their last CC treatment, which shows that CC affects the receptivity of the uterine endometrium.</description><subject>Clomiphene</subject><subject>Clomiphene citrate</subject><subject>Embryo transfer</subject><subject>Embryos</subject><subject>Endocrinology</subject><subject>Endometrium</subject><subject>Gynecology</subject><subject>Hormone replacement cycle</subject><subject>Infertility</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Original</subject><subject>Original Article</subject><subject>Ovaries</subject><subject>Pregnancy rate</subject><subject>Reproductive Medicine</subject><subject>Thawed embryo transfer</subject><subject>Thin uterine endometrium</subject><subject>Urology</subject><subject>Uterus</subject><issn>1445-5781</issn><issn>1447-0578</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNqFkU1P3DAQhq0KVD7KD-ilisSFS8Dj2HF8qVRWfFQCIVXlbGWdCWuUxIvtgJZfj5dQCpUqDpZHnud9PaOXkK9AD4FSeRSACcZyCjwdJfLHT2QbOJc5FbLaeK5FnkrYIjsh3FIKUnH2mWwxxYTiVGyTk1nnertc4ICZsdHXEbO6bdHEkMUFZh4NLqO9t3GVufb5aYzobcJxaFyP0dux_0I227oLuPdy75Lr05Pfs_P84urs5-zHRW64kCIHOQdTqbYyTTlHRmtgRfqqAllI1ShE5A3nJUIDoFIzMU0DtKJgiqqlVbFLvk--y3HeY2NwSBN3eultX_uVdrXV7zuDXegbd69FWYIsi2Rw8GLg3d2IIereBoNdVw_oxqBBSQVScEUTuv8PeutGP6T1dEHLklFeVJAomCjjXQge29dhgOp1SHoKSaeQ9Dok_Zg0395u8ar4k0oC5AQ82A5XHzvqX5fHbF0mJZuUIYmGG_R_h_7_PE_Lna6j</recordid><startdate>201504</startdate><enddate>201504</enddate><creator>Nakagawa, Koji</creator><creator>Kaneyama, Masayo</creator><creator>Nishi, Yayoi</creator><creator>Sugiyama, Rie</creator><creator>Motoyama, Hiroshi</creator><creator>Sugiyama, Rikikazu</creator><general>Springer Japan</general><general>John Wiley & Sons, Inc</general><general>John Wiley and Sons Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FE</scope><scope>8FH</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201504</creationdate><title>Clomiphene citrate affects the receptivity of the uterine endometrium</title><author>Nakagawa, Koji ; Kaneyama, Masayo ; Nishi, Yayoi ; Sugiyama, Rie ; Motoyama, Hiroshi ; Sugiyama, Rikikazu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4575-17b1c89f8cd6be20a123fec817379d9eee4d446e1d119a12be2dd10801c38f083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Clomiphene</topic><topic>Clomiphene citrate</topic><topic>Embryo transfer</topic><topic>Embryos</topic><topic>Endocrinology</topic><topic>Endometrium</topic><topic>Gynecology</topic><topic>Hormone replacement cycle</topic><topic>Infertility</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Original</topic><topic>Original Article</topic><topic>Ovaries</topic><topic>Pregnancy rate</topic><topic>Reproductive Medicine</topic><topic>Thawed embryo transfer</topic><topic>Thin uterine endometrium</topic><topic>Urology</topic><topic>Uterus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nakagawa, Koji</creatorcontrib><creatorcontrib>Kaneyama, Masayo</creatorcontrib><creatorcontrib>Nishi, Yayoi</creatorcontrib><creatorcontrib>Sugiyama, Rie</creatorcontrib><creatorcontrib>Motoyama, Hiroshi</creatorcontrib><creatorcontrib>Sugiyama, Rikikazu</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Reproductive medicine and biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Nakagawa, Koji</au><au>Kaneyama, Masayo</au><au>Nishi, Yayoi</au><au>Sugiyama, Rie</au><au>Motoyama, Hiroshi</au><au>Sugiyama, Rikikazu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clomiphene citrate affects the receptivity of the uterine endometrium</atitle><jtitle>Reproductive medicine and biology</jtitle><stitle>Reprod Med Biol</stitle><addtitle>Reprod Med Biol</addtitle><date>2015-04</date><risdate>2015</risdate><volume>14</volume><issue>2</issue><spage>73</spage><epage>78</epage><pages>73-78</pages><issn>1445-5781</issn><eissn>1447-0578</eissn><abstract>Purpose
To investigate whether clomiphene citrate (CC) affects uterine receptivity or not, we evaluated pregnancy rates (PR) during the hormone replacement cycle (HRC) according to the period between the last day of CC administration and the day of embryo transfer (ET).
Methods
From March 2008 through March 2010, a total of 378 treatment cycles among 378 patients who received CC and had to avoid fresh ET due to a thin uterine endometrium were recruited. All patients underwent thawed ET using HRC. PRs were evaluated according to the period between the last CC treatment and the day of ET.
Results
PR for the groups in which the period between the last CC treatment and the day of ET increased to more than 91 days were significantly higher than that for group in which the period was less than 90 days (
p
< 0.05).
Conclusions
A lower PR was shown by the patients who underwent thawed ET in the HRC within 90 days after their last CC treatment, which shows that CC affects the receptivity of the uterine endometrium.</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>29259405</pmid><doi>10.1007/s12522-014-0195-z</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | Wiley Online Library Open Access |
| subjects | Clomiphene Clomiphene citrate Embryo transfer Embryos Endocrinology Endometrium Gynecology Hormone replacement cycle Infertility Medicine Medicine & Public Health Original Original Article Ovaries Pregnancy rate Reproductive Medicine Thawed embryo transfer Thin uterine endometrium Urology Uterus |
| title | Clomiphene citrate affects the receptivity of the uterine endometrium |
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