Expression of c-Met and hepatocyte growth factor in various gastric pathologies and its association with Helicobacter pylori infection
Activation of the hepatocyte growth factor (HGF)/c-Met signaling pathway was identified to be associated with malignant tumors. The present study aimed at determining the expression of HGF and c-Met in gastric carcinogenesis and its association with Helicobacter pylori infection. Gastric biopsies we...
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| Veröffentlicht in: | Oncology letters 2017-11, Vol.14 (5), p.6151-6155 |
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| creator | Xie, Chuan Yang, Zhen Hu, Yi Cao, Ximei Chen, Jiang Zhu, Yin Lu, Nonghua |
| description | Activation of the hepatocyte growth factor (HGF)/c-Met signaling pathway was identified to be associated with malignant tumors. The present study aimed at determining the expression of HGF and c-Met in gastric carcinogenesis and its association with Helicobacter pylori infection. Gastric biopsies were obtained from 160 H. pylori-negative and -positive patients, including those with chronic gastritis, intestinal metaplasia, dysplasia and gastric cancer (GC). Proteins were extracted from GES-1, gastric epithelial, and AGS, gastric adenocarcinoma, cells following co-culture with H. pylori in vitro. The expression of HGF and c-Met in gastric tissues or cells was determined using immunohistochemistry and western blot analysis. The expression of c-Met increased in GC tissues (72.5%) compared with that in pre-cancerous lesions (17.5, 17.5 and 30%). Additional analysis identified that the expression of HGF and c-Met was significantly increased in the presence of H. pylori infection in dysplasia and gastric cancer samples. Furthermore, H. pylori may activate the HGF/c-Met signaling pathway in vitro, which may contribute to gastric carcinogenesis. |
| doi_str_mv | 10.3892/ol.2017.6983 |
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The present study aimed at determining the expression of HGF and c-Met in gastric carcinogenesis and its association with Helicobacter pylori infection. Gastric biopsies were obtained from 160 H. pylori-negative and -positive patients, including those with chronic gastritis, intestinal metaplasia, dysplasia and gastric cancer (GC). Proteins were extracted from GES-1, gastric epithelial, and AGS, gastric adenocarcinoma, cells following co-culture with H. pylori in vitro. The expression of HGF and c-Met in gastric tissues or cells was determined using immunohistochemistry and western blot analysis. The expression of c-Met increased in GC tissues (72.5%) compared with that in pre-cancerous lesions (17.5, 17.5 and 30%). Additional analysis identified that the expression of HGF and c-Met was significantly increased in the presence of H. pylori infection in dysplasia and gastric cancer samples. Furthermore, H. pylori may activate the HGF/c-Met signaling pathway in vitro, which may contribute to gastric carcinogenesis.</description><identifier>ISSN: 1792-1074</identifier><identifier>EISSN: 1792-1082</identifier><identifier>DOI: 10.3892/ol.2017.6983</identifier><identifier>PMID: 29113260</identifier><language>eng</language><publisher>Greece: D.A. Spandidos</publisher><subject>Biopsy ; c-Met ; Care and treatment ; Complications and side effects ; Development and progression ; Gastric cancer ; Gene expression ; Genetic aspects ; Growth factors ; Health aspects ; Helicobacter infections ; Helicobacter pylori ; hepatocyte growth factor ; Infections ; Kinases ; Stomach diseases</subject><ispartof>Oncology letters, 2017-11, Vol.14 (5), p.6151-6155</ispartof><rights>Copyright © 2017, Spandidos Publications</rights><rights>COPYRIGHT 2017 Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2017</rights><rights>Copyright © 2017, Spandidos Publications 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c539t-b83621885ce133514256233d1d8d89da73b55aef1b5a9f763f624546bf35445f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5661599/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5661599/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,5556,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29113260$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xie, Chuan</creatorcontrib><creatorcontrib>Yang, Zhen</creatorcontrib><creatorcontrib>Hu, Yi</creatorcontrib><creatorcontrib>Cao, Ximei</creatorcontrib><creatorcontrib>Chen, Jiang</creatorcontrib><creatorcontrib>Zhu, Yin</creatorcontrib><creatorcontrib>Lu, Nonghua</creatorcontrib><title>Expression of c-Met and hepatocyte growth factor in various gastric pathologies and its association with Helicobacter pylori infection</title><title>Oncology letters</title><addtitle>Oncol Lett</addtitle><description>Activation of the hepatocyte growth factor (HGF)/c-Met signaling pathway was identified to be associated with malignant tumors. The present study aimed at determining the expression of HGF and c-Met in gastric carcinogenesis and its association with Helicobacter pylori infection. Gastric biopsies were obtained from 160 H. pylori-negative and -positive patients, including those with chronic gastritis, intestinal metaplasia, dysplasia and gastric cancer (GC). Proteins were extracted from GES-1, gastric epithelial, and AGS, gastric adenocarcinoma, cells following co-culture with H. pylori in vitro. The expression of HGF and c-Met in gastric tissues or cells was determined using immunohistochemistry and western blot analysis. The expression of c-Met increased in GC tissues (72.5%) compared with that in pre-cancerous lesions (17.5, 17.5 and 30%). Additional analysis identified that the expression of HGF and c-Met was significantly increased in the presence of H. pylori infection in dysplasia and gastric cancer samples. Furthermore, H. pylori may activate the HGF/c-Met signaling pathway in vitro, which may contribute to gastric carcinogenesis.</description><subject>Biopsy</subject><subject>c-Met</subject><subject>Care and treatment</subject><subject>Complications and side effects</subject><subject>Development and progression</subject><subject>Gastric cancer</subject><subject>Gene expression</subject><subject>Genetic aspects</subject><subject>Growth factors</subject><subject>Health aspects</subject><subject>Helicobacter infections</subject><subject>Helicobacter pylori</subject><subject>hepatocyte growth factor</subject><subject>Infections</subject><subject>Kinases</subject><subject>Stomach diseases</subject><issn>1792-1074</issn><issn>1792-1082</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNptksFvFCEUxidGY5vam2dDojEenHWAgYWLSdNUa7KmFz0ThoEdGnYYgW3df8C_2zfdurZG3gECv_eR9-Wrqpe4WVAhyYcYFqTBywWXgj6pjvFSkho3gjw9nJftUXWa83UDi3EsBH9eHRGJMSW8Oa5-Xfycks3ZxxFFh0z91Rakxx4NdtIlml2xaJ3ibRmQ06bEhPyIbnTycZvRWueSvEFADjHEtbf5rtcX2HOOxusyC996aL-0wZvYgYhNaNqFmDxoOWtm5EX1zOmQ7en9flJ9_3Tx7fyyXl19_nJ-tqoNo7LUnaCcwAzMWEwpwy1hnFDa4170QvZ6STvGtHW4Y1q6JaeOk5a1vHOUtS1z9KT6uNedtt3G9saOJemgpuQ3Ou1U1F49fhn9oNbxRjHOMZMSBN7dC6T4Y2tzURufjQ1BjxYsUViCx4ywlgH6-h_0Om7TCOMBJZhkMID8S611sAoMifCvmUXVGSNUYkHETC3-Q0H1dgOujtZ5uH_U8PZBw2B1KEOOYTubnR-D7_egSTHnZN3BDNyoOWMqBjVnTM0ZA_zVQwMP8J9EAfBmD-QJouD7mA_M1apuoO50fgNxwthn</recordid><startdate>20171101</startdate><enddate>20171101</enddate><creator>Xie, Chuan</creator><creator>Yang, Zhen</creator><creator>Hu, Yi</creator><creator>Cao, Ximei</creator><creator>Chen, Jiang</creator><creator>Zhu, Yin</creator><creator>Lu, Nonghua</creator><general>D.A. Spandidos</general><general>Spandidos Publications</general><general>Spandidos Publications UK Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20171101</creationdate><title>Expression of c-Met and hepatocyte growth factor in various gastric pathologies and its association with Helicobacter pylori infection</title><author>Xie, Chuan ; Yang, Zhen ; Hu, Yi ; Cao, Ximei ; Chen, Jiang ; Zhu, Yin ; Lu, Nonghua</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c539t-b83621885ce133514256233d1d8d89da73b55aef1b5a9f763f624546bf35445f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Biopsy</topic><topic>c-Met</topic><topic>Care and treatment</topic><topic>Complications and side effects</topic><topic>Development and progression</topic><topic>Gastric cancer</topic><topic>Gene expression</topic><topic>Genetic aspects</topic><topic>Growth factors</topic><topic>Health aspects</topic><topic>Helicobacter infections</topic><topic>Helicobacter pylori</topic><topic>hepatocyte growth factor</topic><topic>Infections</topic><topic>Kinases</topic><topic>Stomach diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xie, Chuan</creatorcontrib><creatorcontrib>Yang, Zhen</creatorcontrib><creatorcontrib>Hu, Yi</creatorcontrib><creatorcontrib>Cao, Ximei</creatorcontrib><creatorcontrib>Chen, Jiang</creatorcontrib><creatorcontrib>Zhu, Yin</creatorcontrib><creatorcontrib>Lu, Nonghua</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Oncology letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xie, Chuan</au><au>Yang, Zhen</au><au>Hu, Yi</au><au>Cao, Ximei</au><au>Chen, Jiang</au><au>Zhu, Yin</au><au>Lu, Nonghua</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of c-Met and hepatocyte growth factor in various gastric pathologies and its association with Helicobacter pylori infection</atitle><jtitle>Oncology letters</jtitle><addtitle>Oncol Lett</addtitle><date>2017-11-01</date><risdate>2017</risdate><volume>14</volume><issue>5</issue><spage>6151</spage><epage>6155</epage><pages>6151-6155</pages><issn>1792-1074</issn><eissn>1792-1082</eissn><abstract>Activation of the hepatocyte growth factor (HGF)/c-Met signaling pathway was identified to be associated with malignant tumors. The present study aimed at determining the expression of HGF and c-Met in gastric carcinogenesis and its association with Helicobacter pylori infection. Gastric biopsies were obtained from 160 H. pylori-negative and -positive patients, including those with chronic gastritis, intestinal metaplasia, dysplasia and gastric cancer (GC). Proteins were extracted from GES-1, gastric epithelial, and AGS, gastric adenocarcinoma, cells following co-culture with H. pylori in vitro. The expression of HGF and c-Met in gastric tissues or cells was determined using immunohistochemistry and western blot analysis. The expression of c-Met increased in GC tissues (72.5%) compared with that in pre-cancerous lesions (17.5, 17.5 and 30%). Additional analysis identified that the expression of HGF and c-Met was significantly increased in the presence of H. pylori infection in dysplasia and gastric cancer samples. Furthermore, H. pylori may activate the HGF/c-Met signaling pathway in vitro, which may contribute to gastric carcinogenesis.</abstract><cop>Greece</cop><pub>D.A. Spandidos</pub><pmid>29113260</pmid><doi>10.3892/ol.2017.6983</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | Spandidos Publications Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Biopsy c-Met Care and treatment Complications and side effects Development and progression Gastric cancer Gene expression Genetic aspects Growth factors Health aspects Helicobacter infections Helicobacter pylori hepatocyte growth factor Infections Kinases Stomach diseases |
| title | Expression of c-Met and hepatocyte growth factor in various gastric pathologies and its association with Helicobacter pylori infection |
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