Downregulated long non-coding RNA TCONS_00068220 upregulates apoptosis in gastric cancer cells
Long non-coding RNAs (lncRNAs) are emerging as a fundamental class of biological effect or molecules that perform pivotal functions in the regulation of the genome. With advances in bioinformatics and genomics, extensive identification and characterization of lncRNAs is now possible. They regulate c...
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| Veröffentlicht in: | Oncology letters 2017-11, Vol.14 (5), p.6143-6150 |
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| creator | Zhao, Zhiwei Xue, Junlai Song, Yan Liu, Tianyou Piao, Daxun |
| description | Long non-coding RNAs (lncRNAs) are emerging as a fundamental class of biological effect or molecules that perform pivotal functions in the regulation of the genome. With advances in bioinformatics and genomics, extensive identification and characterization of lncRNAs is now possible. They regulate cellular growth, differentiation and apoptosis. Dysregulation of lncRNAs has been associated with numerous types of human cancer. In the present study, the expression profile of differentially expressed genes (DEGs) and lncRNAs in gastric cancer (GC) samples and normal tissue samples was evaluated with bioinformatics. The biological functions of the predicted lncRNA TCONS_00068220 were focused on; the DEGs co-expressed with TCONS_00068220 were enriched in cancer-associated pathways. TCONS_00068220 was demonstrated to be upregulated in GC tissues and cell lines compared with normal controls. In addition, an increased rate of apoptosis was observed in NCI-N87 cells following transfection with small interfering RNA against TCONS_00068220. These data suggest that TCONS_00068220 may be associated with the pathogenesis of GC, and it may serve as a potential therapeutic target. |
| doi_str_mv | 10.3892/ol.2017.6977 |
| format | Article |
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With advances in bioinformatics and genomics, extensive identification and characterization of lncRNAs is now possible. They regulate cellular growth, differentiation and apoptosis. Dysregulation of lncRNAs has been associated with numerous types of human cancer. In the present study, the expression profile of differentially expressed genes (DEGs) and lncRNAs in gastric cancer (GC) samples and normal tissue samples was evaluated with bioinformatics. The biological functions of the predicted lncRNA TCONS_00068220 were focused on; the DEGs co-expressed with TCONS_00068220 were enriched in cancer-associated pathways. TCONS_00068220 was demonstrated to be upregulated in GC tissues and cell lines compared with normal controls. In addition, an increased rate of apoptosis was observed in NCI-N87 cells following transfection with small interfering RNA against TCONS_00068220. These data suggest that TCONS_00068220 may be associated with the pathogenesis of GC, and it may serve as a potential therapeutic target.</description><identifier>ISSN: 1792-1074</identifier><identifier>EISSN: 1792-1082</identifier><identifier>DOI: 10.3892/ol.2017.6977</identifier><identifier>PMID: 29113259</identifier><language>eng</language><publisher>Greece: D.A. Spandidos</publisher><subject>Apoptosis ; Bioinformatics ; Bladder cancer ; Cancer therapies ; Care and treatment ; Cell cycle ; Cell growth ; Colorectal cancer ; Deoxyribonucleic acid ; Development and progression ; DNA ; Encyclopedias ; Gastric cancer ; Gene expression ; Genetic aspects ; Genomes ; Genomics ; Health aspects ; Hospitals ; long non-coding RNAs ; Metastasis ; Oncology ; Pathogenesis ; RNA ; RNA-sequencing data ; Stomach cancer ; TCONS_00068220 ; Tumor necrosis factor-TNF</subject><ispartof>Oncology letters, 2017-11, Vol.14 (5), p.6143-6150</ispartof><rights>Copyright © 2017, Spandidos Publications</rights><rights>COPYRIGHT 2017 Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2017</rights><rights>Copyright © 2017, Spandidos Publications 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5661388/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5661388/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,5570,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29113259$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhao, Zhiwei</creatorcontrib><creatorcontrib>Xue, Junlai</creatorcontrib><creatorcontrib>Song, Yan</creatorcontrib><creatorcontrib>Liu, Tianyou</creatorcontrib><creatorcontrib>Piao, Daxun</creatorcontrib><title>Downregulated long non-coding RNA TCONS_00068220 upregulates apoptosis in gastric cancer cells</title><title>Oncology letters</title><addtitle>Oncol Lett</addtitle><description>Long non-coding RNAs (lncRNAs) are emerging as a fundamental class of biological effect or molecules that perform pivotal functions in the regulation of the genome. With advances in bioinformatics and genomics, extensive identification and characterization of lncRNAs is now possible. They regulate cellular growth, differentiation and apoptosis. Dysregulation of lncRNAs has been associated with numerous types of human cancer. In the present study, the expression profile of differentially expressed genes (DEGs) and lncRNAs in gastric cancer (GC) samples and normal tissue samples was evaluated with bioinformatics. The biological functions of the predicted lncRNA TCONS_00068220 were focused on; the DEGs co-expressed with TCONS_00068220 were enriched in cancer-associated pathways. TCONS_00068220 was demonstrated to be upregulated in GC tissues and cell lines compared with normal controls. In addition, an increased rate of apoptosis was observed in NCI-N87 cells following transfection with small interfering RNA against TCONS_00068220. These data suggest that TCONS_00068220 may be associated with the pathogenesis of GC, and it may serve as a potential therapeutic target.</description><subject>Apoptosis</subject><subject>Bioinformatics</subject><subject>Bladder cancer</subject><subject>Cancer therapies</subject><subject>Care and treatment</subject><subject>Cell cycle</subject><subject>Cell growth</subject><subject>Colorectal cancer</subject><subject>Deoxyribonucleic acid</subject><subject>Development and progression</subject><subject>DNA</subject><subject>Encyclopedias</subject><subject>Gastric cancer</subject><subject>Gene expression</subject><subject>Genetic aspects</subject><subject>Genomes</subject><subject>Genomics</subject><subject>Health aspects</subject><subject>Hospitals</subject><subject>long non-coding RNAs</subject><subject>Metastasis</subject><subject>Oncology</subject><subject>Pathogenesis</subject><subject>RNA</subject><subject>RNA-sequencing data</subject><subject>Stomach cancer</subject><subject>TCONS_00068220</subject><subject>Tumor necrosis factor-TNF</subject><issn>1792-1074</issn><issn>1792-1082</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNptkt9v0zAQxyMEYtPYG88oEgjxQErsOI79glQV2JCqVYLxiuVenNaT6wt2AuK_x1m3siJ8Dz7Zn_veD12WPSflrBKSvkM3oyVpZlw2zaPslDSSFqQU9PHBb9hJdh7jTZlOzYkQ_Gl2QiUhFa3lafb9A_7ywWxGpwfT5g79JvfoC8DWJvfL1Ty_XqyuvqoUzgWlZT7293jMdY_9gNHG3Pp8o-MQLOSgPZiQg3EuPsuedNpFc353n2XfPn28XlwWy9XF58V8WQCTfCi06AyQcp1KFNw0DBhrO14zI6XgAJRA1QjGmZQtmMqA6NbQsQo0tJJAWVdn2fu9bj-udyZBfgjaqT7YnQ6_FWqrjn-83aoN_lQ156QSIgm8uRMI-GM0cVA7G6cWtDc4RkVkmh1L1ciEvvwHvcEx-NReokQtedKs_lIb7YyyvsOUFyZRNa9pJYmgt2ln_6GStWZnAb3pbHo_Cnj9IGBrtBu2Ed04WPTxGHy7ByFgjMF0h2GQUk27o9CpaXfUtDsJf_FwgAf4flMS8GoPxF771rYYD8xqWZTJbnX-ALqpyII</recordid><startdate>20171101</startdate><enddate>20171101</enddate><creator>Zhao, Zhiwei</creator><creator>Xue, Junlai</creator><creator>Song, Yan</creator><creator>Liu, Tianyou</creator><creator>Piao, Daxun</creator><general>D.A. Spandidos</general><general>Spandidos Publications</general><general>Spandidos Publications UK Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20171101</creationdate><title>Downregulated long non-coding RNA TCONS_00068220 upregulates apoptosis in gastric cancer cells</title><author>Zhao, Zhiwei ; Xue, Junlai ; Song, Yan ; Liu, Tianyou ; Piao, Daxun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c496t-a8fec10b00586e74c44df654e9986cc21c37846499dce3ec8fbcf43cacd91c053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Apoptosis</topic><topic>Bioinformatics</topic><topic>Bladder cancer</topic><topic>Cancer therapies</topic><topic>Care and treatment</topic><topic>Cell cycle</topic><topic>Cell growth</topic><topic>Colorectal cancer</topic><topic>Deoxyribonucleic acid</topic><topic>Development and progression</topic><topic>DNA</topic><topic>Encyclopedias</topic><topic>Gastric cancer</topic><topic>Gene expression</topic><topic>Genetic aspects</topic><topic>Genomes</topic><topic>Genomics</topic><topic>Health aspects</topic><topic>Hospitals</topic><topic>long non-coding RNAs</topic><topic>Metastasis</topic><topic>Oncology</topic><topic>Pathogenesis</topic><topic>RNA</topic><topic>RNA-sequencing data</topic><topic>Stomach cancer</topic><topic>TCONS_00068220</topic><topic>Tumor necrosis factor-TNF</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhao, Zhiwei</creatorcontrib><creatorcontrib>Xue, Junlai</creatorcontrib><creatorcontrib>Song, Yan</creatorcontrib><creatorcontrib>Liu, Tianyou</creatorcontrib><creatorcontrib>Piao, Daxun</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Oncology letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhao, Zhiwei</au><au>Xue, Junlai</au><au>Song, Yan</au><au>Liu, Tianyou</au><au>Piao, Daxun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Downregulated long non-coding RNA TCONS_00068220 upregulates apoptosis in gastric cancer cells</atitle><jtitle>Oncology letters</jtitle><addtitle>Oncol Lett</addtitle><date>2017-11-01</date><risdate>2017</risdate><volume>14</volume><issue>5</issue><spage>6143</spage><epage>6150</epage><pages>6143-6150</pages><issn>1792-1074</issn><eissn>1792-1082</eissn><abstract>Long non-coding RNAs (lncRNAs) are emerging as a fundamental class of biological effect or molecules that perform pivotal functions in the regulation of the genome. With advances in bioinformatics and genomics, extensive identification and characterization of lncRNAs is now possible. They regulate cellular growth, differentiation and apoptosis. Dysregulation of lncRNAs has been associated with numerous types of human cancer. In the present study, the expression profile of differentially expressed genes (DEGs) and lncRNAs in gastric cancer (GC) samples and normal tissue samples was evaluated with bioinformatics. The biological functions of the predicted lncRNA TCONS_00068220 were focused on; the DEGs co-expressed with TCONS_00068220 were enriched in cancer-associated pathways. TCONS_00068220 was demonstrated to be upregulated in GC tissues and cell lines compared with normal controls. In addition, an increased rate of apoptosis was observed in NCI-N87 cells following transfection with small interfering RNA against TCONS_00068220. These data suggest that TCONS_00068220 may be associated with the pathogenesis of GC, and it may serve as a potential therapeutic target.</abstract><cop>Greece</cop><pub>D.A. Spandidos</pub><pmid>29113259</pmid><doi>10.3892/ol.2017.6977</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | Spandidos Publications Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Apoptosis Bioinformatics Bladder cancer Cancer therapies Care and treatment Cell cycle Cell growth Colorectal cancer Deoxyribonucleic acid Development and progression DNA Encyclopedias Gastric cancer Gene expression Genetic aspects Genomes Genomics Health aspects Hospitals long non-coding RNAs Metastasis Oncology Pathogenesis RNA RNA-sequencing data Stomach cancer TCONS_00068220 Tumor necrosis factor-TNF |
| title | Downregulated long non-coding RNA TCONS_00068220 upregulates apoptosis in gastric cancer cells |
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