Impact of intracellular glyceraldehyde-derived advanced glycation end-products on human hepatocyte cell death

Hepatocyte cell death is a key feature of nonalcoholic steatohepatitis (NASH); however, the pathogenesis of NASH currently remains unclear. We aimed to investigate the effects of intracellular glyceraldehyde (GA)-derived advanced glycation end-products (GA-AGEs) on human hepatocyte cell death. The a...

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Veröffentlicht in:	Scientific reports 2017-10, Vol.7 (1), p.14282-11, Article 14282
Hauptverfasser:	Sakasai-Sakai, Akiko, Takata, Takanobu, Takino, Jun-ichi, Takeuchi, Masayoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	13/2 13/31 14/1 14/34 631/80/82 692/4020/4021 Advanced glycosylation end products Apoptosis Camptothecin Caspase Caspase 3 - metabolism Caspase-3 Cell death Cell Death - drug effects Cell Death - physiology Deoxyribonucleic acid DNA DNA damage DNA Damage - drug effects DNA Damage - physiology Gangrene Glycation End Products, Advanced - administration & dosage Glycation End Products, Advanced - metabolism Glyceraldehyde Glyceraldehyde - administration & dosage Glyceraldehyde - metabolism Glycosylation Hep G2 Cells Hepatocytes - drug effects Hepatocytes - metabolism Hepatocytes - pathology Humanities and Social Sciences Humans Inflammation Intracellular Intracellular Space - drug effects Intracellular Space - metabolism Mortality multidisciplinary Necrosis Non-alcoholic Fatty Liver Disease - drug therapy Non-alcoholic Fatty Liver Disease - metabolism Pathogenesis Protective Agents - administration & dosage Science Science (multidisciplinary)
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