Postprandial Blood Glucose Outweighs Fasting Blood Glucose and HbA1c in screening Coronary Heart Disease
The objective of the present study is to assess the performance of fasting blood glucose (FBG), postprandial blood glucose (PBG), and glycated hemoglobin (HbA1c) as screening for coronary heart disease (CHD) in an inpatient population undergoing coronary angiography. 1852 consecutive patients schedu...
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| description | The objective of the present study is to assess the performance of fasting blood glucose (FBG), postprandial blood glucose (PBG), and glycated hemoglobin (HbA1c) as screening for coronary heart disease (CHD) in an inpatient population undergoing coronary angiography. 1852 consecutive patients scheduled for coronary angiography were classified into Normal Glucose Tolerance (NGT), Impaired Glucose Regulation (IGR), and diabetes, based on FBG, PBG, and HbA1c. Correlations of Gensini score with glucose metabolism and insulin resistance were analyzed. The associations between glycemic variables and Gensini score or the presence of CHD were analyzed by multiple linear regression and logistic regression, respectively. CHD was diagnosed in 488, 622, and 414 patients with NGT, IGR, and diabetes, respectively. Gensini score was positively correlated with FBG (r = 0.09, p |
| doi_str_mv | 10.1038/s41598-017-14152-y |
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Correlations of Gensini score with glucose metabolism and insulin resistance were analyzed. The associations between glycemic variables and Gensini score or the presence of CHD were analyzed by multiple linear regression and logistic regression, respectively. CHD was diagnosed in 488, 622, and 414 patients with NGT, IGR, and diabetes, respectively. Gensini score was positively correlated with FBG (r = 0.09, p < 0.01), PBG (r = 0.20, p < 0.01), and HbA1c (r = 0.19, p < 0.01). Gensini score was not correlated with fasting insulin (r = −0.081, p = 0.36), post-prandial insulin (r = −0.02, p = 0.61), or HOMAIR (r = −0.0059, p = 0.13). When FBG, PBG and HbA1c were pooled altogether, only PBG persisted in its association with Gensini score and the prevalence of CHD. The severity of CHD was associated with glucose rather than insulin resistance in this Chinese population. PBG was optimally correlated with the presence and severity of CHD.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-017-14152-y</identifier><identifier>PMID: 29079813</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/163/2743/137/138 ; 692/4019/2776 ; Angiography ; Blood ; Blood glucose ; Cardiovascular disease ; Cardiovascular diseases ; Coronary artery disease ; Diabetes ; Diabetes mellitus ; Fasting ; Glucose ; Glucose metabolism ; Glucose tolerance ; Heart diseases ; Hemoglobin ; Humanities and Social Sciences ; Insulin ; Insulin resistance ; Laboratory testing ; Medical imaging ; multidisciplinary ; Performance assessment ; Science ; Science (multidisciplinary)</subject><ispartof>Scientific reports, 2017-10, Vol.7 (1), p.14212-7, Article 14212</ispartof><rights>The Author(s) 2017</rights><rights>2017. 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Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-88c52c6c0c3c32abb1aeef45073b3d6110bc952f9e8768442fceaf3a93f7d4cb3</citedby><cites>FETCH-LOGICAL-c474t-88c52c6c0c3c32abb1aeef45073b3d6110bc952f9e8768442fceaf3a93f7d4cb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5660170/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5660170/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,41120,42189,51576,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29079813$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jiang, Jingjing</creatorcontrib><creatorcontrib>Zhao, Lin</creatorcontrib><creatorcontrib>Lin, Liu</creatorcontrib><creatorcontrib>Gui, Minghui</creatorcontrib><creatorcontrib>Aleteng, Qiqige</creatorcontrib><creatorcontrib>Wu, Bingjie</creatorcontrib><creatorcontrib>Wang, Shanshan</creatorcontrib><creatorcontrib>Pan, Baishen</creatorcontrib><creatorcontrib>Ling, Yan</creatorcontrib><creatorcontrib>Gao, Xin</creatorcontrib><title>Postprandial Blood Glucose Outweighs Fasting Blood Glucose and HbA1c in screening Coronary Heart Disease</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>The objective of the present study is to assess the performance of fasting blood glucose (FBG), postprandial blood glucose (PBG), and glycated hemoglobin (HbA1c) as screening for coronary heart disease (CHD) in an inpatient population undergoing coronary angiography. 1852 consecutive patients scheduled for coronary angiography were classified into Normal Glucose Tolerance (NGT), Impaired Glucose Regulation (IGR), and diabetes, based on FBG, PBG, and HbA1c. Correlations of Gensini score with glucose metabolism and insulin resistance were analyzed. The associations between glycemic variables and Gensini score or the presence of CHD were analyzed by multiple linear regression and logistic regression, respectively. CHD was diagnosed in 488, 622, and 414 patients with NGT, IGR, and diabetes, respectively. Gensini score was positively correlated with FBG (r = 0.09, p < 0.01), PBG (r = 0.20, p < 0.01), and HbA1c (r = 0.19, p < 0.01). Gensini score was not correlated with fasting insulin (r = −0.081, p = 0.36), post-prandial insulin (r = −0.02, p = 0.61), or HOMAIR (r = −0.0059, p = 0.13). When FBG, PBG and HbA1c were pooled altogether, only PBG persisted in its association with Gensini score and the prevalence of CHD. The severity of CHD was associated with glucose rather than insulin resistance in this Chinese population. PBG was optimally correlated with the presence and severity of CHD.</description><subject>692/163/2743/137/138</subject><subject>692/4019/2776</subject><subject>Angiography</subject><subject>Blood</subject><subject>Blood glucose</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular diseases</subject><subject>Coronary artery disease</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Fasting</subject><subject>Glucose</subject><subject>Glucose metabolism</subject><subject>Glucose tolerance</subject><subject>Heart diseases</subject><subject>Hemoglobin</subject><subject>Humanities and Social Sciences</subject><subject>Insulin</subject><subject>Insulin resistance</subject><subject>Laboratory testing</subject><subject>Medical imaging</subject><subject>multidisciplinary</subject><subject>Performance assessment</subject><subject>Science</subject><subject>Science 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titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jiang, Jingjing</au><au>Zhao, Lin</au><au>Lin, Liu</au><au>Gui, Minghui</au><au>Aleteng, Qiqige</au><au>Wu, Bingjie</au><au>Wang, Shanshan</au><au>Pan, Baishen</au><au>Ling, Yan</au><au>Gao, Xin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Postprandial Blood Glucose Outweighs Fasting Blood Glucose and HbA1c in screening Coronary Heart Disease</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2017-10-27</date><risdate>2017</risdate><volume>7</volume><issue>1</issue><spage>14212</spage><epage>7</epage><pages>14212-7</pages><artnum>14212</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>The objective of the present study is to assess the performance of fasting blood glucose (FBG), postprandial blood glucose (PBG), and glycated hemoglobin (HbA1c) as screening for coronary heart disease (CHD) in an inpatient population undergoing coronary angiography. 1852 consecutive patients scheduled for coronary angiography were classified into Normal Glucose Tolerance (NGT), Impaired Glucose Regulation (IGR), and diabetes, based on FBG, PBG, and HbA1c. Correlations of Gensini score with glucose metabolism and insulin resistance were analyzed. The associations between glycemic variables and Gensini score or the presence of CHD were analyzed by multiple linear regression and logistic regression, respectively. CHD was diagnosed in 488, 622, and 414 patients with NGT, IGR, and diabetes, respectively. Gensini score was positively correlated with FBG (r = 0.09, p < 0.01), PBG (r = 0.20, p < 0.01), and HbA1c (r = 0.19, p < 0.01). Gensini score was not correlated with fasting insulin (r = −0.081, p = 0.36), post-prandial insulin (r = −0.02, p = 0.61), or HOMAIR (r = −0.0059, p = 0.13). When FBG, PBG and HbA1c were pooled altogether, only PBG persisted in its association with Gensini score and the prevalence of CHD. The severity of CHD was associated with glucose rather than insulin resistance in this Chinese population. PBG was optimally correlated with the presence and severity of CHD.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>29079813</pmid><doi>10.1038/s41598-017-14152-y</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 692/163/2743/137/138 692/4019/2776 Angiography Blood Blood glucose Cardiovascular disease Cardiovascular diseases Coronary artery disease Diabetes Diabetes mellitus Fasting Glucose Glucose metabolism Glucose tolerance Heart diseases Hemoglobin Humanities and Social Sciences Insulin Insulin resistance Laboratory testing Medical imaging multidisciplinary Performance assessment Science Science (multidisciplinary) |
| title | Postprandial Blood Glucose Outweighs Fasting Blood Glucose and HbA1c in screening Coronary Heart Disease |
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