Optical clearing and fluorescence deep-tissue imaging for 3D quantitative analysis of the brain tumor microenvironment

Background Three-dimensional visualization of the brain vasculature and its interactions with surrounding cells may shed light on diseases where aberrant microvascular organization is involved, including glioblastoma (GBM). Intravital confocal imaging allows 3D visualization of microvascular structu...

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Veröffentlicht in:	Angiogenesis (London) 2017-11, Vol.20 (4), p.533-546
Hauptverfasser:	Lagerweij, Tonny, Dusoswa, Sophie A., Negrean, Adrian, Hendrikx, Esther M. L., de Vries, Helga E., Kole, Jeroen, Garcia-Vallejo, Juan J., Mansvelder, Huibert D., Vandertop, W. Peter, Noske, David P., Tannous, Bakhos A., Musters, René J. P., van Kooyk, Yvette, Wesseling, Pieter, Zhao, Xi Wen, Wurdinger, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Aberration Animal models Animal tissues Animals Biomedical and Life Sciences Biomedicine Brain Brain - blood supply Brain - pathology Brain cancer Brain Neoplasms - pathology Brain tumors Cancer Research Cardiology Cell Biology Clearing Computational neuroscience Computer networks Female Fluorescence Glioblastoma Glioblastoma - blood supply Glioblastoma - pathology Imaging Imaging, Three-Dimensional Intravital Microscopy Lectins - metabolism Mice, Nude Microscopic analysis Microscopy Microvasculature Microvessels - pathology Neovascularization, Pathologic - pathology Neuroimaging Oncology Ophthalmology Optical Phenomena Original Paper Parenchyma Photons Quantitative analysis Rodents Substantia alba Substantia grisea Tumor cells Tumor Microenvironment Tumors Visualization Workflow
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