Ribosome Collision Is Critical for Quality Control during No-Go Decay

No-go decay (NGD) is a eukaryotic quality control mechanism that evolved to cope with translational arrests. The process is characterized by an endonucleolytic cleavage near the stall sequence, but the mechanistic details are unclear. Our analysis of cleavage sites indicates that cleavage requires m...

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Veröffentlicht in:	Molecular cell 2017-10, Vol.68 (2), p.361-373.e5
Hauptverfasser:	Simms, Carrie L., Yan, Liewei L., Zaher, Hani S.
Format:	Artikel
Sprache:	eng
Schlagworte:	no-go decay quality control ribosomal protein ubiquitination ribosome Ribosomes - genetics Ribosomes - metabolism RNA Stability - physiology RNA, Fungal - genetics RNA, Fungal - metabolism Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism stalling translation
Online-Zugang:	Volltext
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