Hydroxypropyl methylcellulose-based controlled release dosage by melt extrusion and 3D printing: Structure and drug release correlation

[Display omitted] •Novel and efficient manufacturing method by coupling of HME and 3D printing.•Produce different structured tablets with designed drug released profiles.•Tablets #3, 5, 6 and 9 can achieve zero order drug release.•Structure and HPMC matrix contribute to the steady and constant drug...

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Veröffentlicht in:	Carbohydrate polymers 2017-12, Vol.177, p.49-57
Hauptverfasser:	Zhang, Jiaxiang, Yang, Weiwei, Vo, Anh Q., Feng, Xin, Ye, Xingyou, Kim, Dong Wuk, Repka, Michael A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetaminophen Controlled release Delayed-Action Preparations - chemistry Dissolution kinetics Fused deposition modeling 3D printing Hot-melt extrusion Hydroxypropyl methylcellulose Hypromellose Derivatives - chemistry Methylcellulose - chemistry Printing, Three-Dimensional Solubility Tablets - chemistry Technology, Pharmaceutical - methods Technology, Pharmaceutical - standards
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