Orthotopic patient-derived xenografts of paediatric solid tumours

A protocol producing orthotopic patient-derived xenografts at diagnosis, recurrence, and autopsy demonstrates proof of principle for using these tumours for basic and translational research on paediatric solid tumours. Xenograft archive Preclinical models of paediatric solid tumours that could help...

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Veröffentlicht in:	Nature (London) 2017-09, Vol.549 (7670), p.96-100
Hauptverfasser:	Stewart, Elizabeth, Federico, Sara M., Chen, Xiang, Shelat, Anang A., Bradley, Cori, Gordon, Brittney, Karlstrom, Asa, Twarog, Nathaniel R., Clay, Michael R., Bahrami, Armita, Freeman, Burgess B., Xu, Beisi, Zhou, Xin, Wu, Jianrong, Honnell, Victoria, Ocarz, Monica, Blankenship, Kaley, Dapper, Jason, Mardis, Elaine R., Wilson, Richard K., Downing, James, Zhang, Jinghui, Easton, John, Pappo, Alberto, Dyer, Michael A.
Format:	Artikel
Sprache:	eng
Schlagworte:	13 631/208/68/2486 631/67/70 Animals Autopsy Bortezomib - pharmacology Bortezomib - therapeutic use Camptothecin - analogs & derivatives Camptothecin - pharmacology Camptothecin - therapeutic use Cancer Care and treatment Cell Cycle Proteins - antagonists & inhibitors Chemotherapy Child Children Children & youth Clone Cells Diagnosis Drug Therapy, Combination Epigenesis, Genetic Female Gene expression Genomes Heterografts - drug effects Heterografts - metabolism Heterografts - pathology Heterografts - transplantation High-Throughput Screening Assays - methods Humanities and Social Sciences Humans Hydroxamic Acids - pharmacology Hydroxamic Acids - therapeutic use Indoles - pharmacology Indoles - therapeutic use Irinotecan letter Methods Mice multidisciplinary Multiple myeloma Mutation Neoplasms - drug therapy Neoplasms - genetics Neuroblastoma Nuclear Proteins - antagonists & inhibitors Panobinostat Patients Pediatric tumors Pediatrics Protein-Tyrosine Kinases - antagonists & inhibitors Pyrazoles - pharmacology Pyrazoles - therapeutic use Pyrimidines - pharmacology Pyrimidines - therapeutic use Pyrimidinones Rhabdomyosarcoma Rhabdomyosarcoma - drug therapy Rhabdomyosarcoma - genetics Science Tumors Vincristine Vincristine - pharmacology Vincristine - therapeutic use Xenograft Model Antitumor Assays - methods Xenografts Xenotransplantation
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