A Translational Systems Pharmacology Model for Aβ Kinetics in Mouse, Monkey, and Human

A mechanistic model of amyloid beta production, degradation, and distribution was constructed for mouse, monkey, and human, calibrated and externally verified across multiple datasets. Simulations of single‐dose avagacestat treatment demonstrate that the Aβ42 brain inhibition may exceed that in cere...

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Veröffentlicht in:	CPT: pharmacometrics and systems pharmacology 2017-10, Vol.6 (10), p.666-675
Hauptverfasser:	Karelina, T, Demin, O, Nicholas, T, Lu, Y, Duvvuri, S, Barton, HA
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Alzheimer Disease - drug therapy Alzheimer Disease - metabolism Alzheimer's disease Amyloid beta-Peptides - antagonists & inhibitors Amyloid beta-Peptides - chemistry Animals Biomarkers Brain - metabolism Brain research Clinical trials Dose-Response Relationship, Drug Drug dosages Female Haplorhini Humans Hypotheses Kinetics Mice Models, Statistical Original Oxadiazoles - pharmacology Plasma R&D Research & development Sulfonamides - pharmacology Translational Medical Research
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