Innate lymphoid cells and the MHC
Innate lymphoid cells (ILCs) are a new class of immune cells that include natural killer (NK) cells and appear to be the innate counterparts to CD4+ helper T cells and CD8+ cytotoxic T cells based on developmental and functional similarities. Like T cells, both NK cells and other ILCs also show conn...
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| Veröffentlicht in: | HLA 2016-01, Vol.87 (1), p.5-11 |
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| container_title | HLA |
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| creator | Robinette, M. L. Colonna, M. |
| description | Innate lymphoid cells (ILCs) are a new class of immune cells that include natural killer (NK) cells and appear to be the innate counterparts to CD4+ helper T cells and CD8+ cytotoxic T cells based on developmental and functional similarities. Like T cells, both NK cells and other ILCs also show connections to the major histocompatibility complex (MHC). In human and mouse, NK cells recognize and respond to classical and nonclassical MHC I molecules as well as structural homologues, whereas mouse ILCs have recently been shown to express MHC II. We describe the history of MHC I recognition by NK cells and discuss emerging roles for MHC II expression by ILC subsets, making comparisons between both mouse and human when possible. |
| doi_str_mv | 10.1111/tan.12723 |
| format | Article |
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We describe the history of MHC I recognition by NK cells and discuss emerging roles for MHC II expression by ILC subsets, making comparisons between both mouse and human when possible.</description><identifier>ISSN: 2059-2302</identifier><identifier>EISSN: 2059-2310</identifier><identifier>DOI: 10.1111/tan.12723</identifier><identifier>PMID: 26812060</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Animals ; Antigens, CD - genetics ; Antigens, CD - immunology ; cytokines ; Cytokines - genetics ; Cytokines - immunology ; Gene Expression ; human ; human leukocyte antigen ; Humans ; Immunity, Innate ; innate ; Innate lymphoid cells ; Killer Cells, Natural - cytology ; Killer Cells, Natural - immunology ; Major Histocompatibility Complex ; MHC ; Mice ; mouse ; Receptors, NK Cell Lectin-Like - genetics ; Receptors, NK Cell Lectin-Like - immunology ; Species Specificity ; T-Lymphocytes, Cytotoxic - cytology ; T-Lymphocytes, Cytotoxic - immunology ; T-Lymphocytes, Helper-Inducer - cytology ; T-Lymphocytes, Helper-Inducer - immunology</subject><ispartof>HLA, 2016-01, Vol.87 (1), p.5-11</ispartof><rights>2015 John Wiley & Sons A/S. 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L.</creatorcontrib><creatorcontrib>Colonna, M.</creatorcontrib><title>Innate lymphoid cells and the MHC</title><title>HLA</title><addtitle>HLA</addtitle><description>Innate lymphoid cells (ILCs) are a new class of immune cells that include natural killer (NK) cells and appear to be the innate counterparts to CD4+ helper T cells and CD8+ cytotoxic T cells based on developmental and functional similarities. Like T cells, both NK cells and other ILCs also show connections to the major histocompatibility complex (MHC). In human and mouse, NK cells recognize and respond to classical and nonclassical MHC I molecules as well as structural homologues, whereas mouse ILCs have recently been shown to express MHC II. We describe the history of MHC I recognition by NK cells and discuss emerging roles for MHC II expression by ILC subsets, making comparisons between both mouse and human when possible.</description><subject>Animals</subject><subject>Antigens, CD - genetics</subject><subject>Antigens, CD - immunology</subject><subject>cytokines</subject><subject>Cytokines - genetics</subject><subject>Cytokines - immunology</subject><subject>Gene Expression</subject><subject>human</subject><subject>human leukocyte antigen</subject><subject>Humans</subject><subject>Immunity, Innate</subject><subject>innate</subject><subject>Innate lymphoid cells</subject><subject>Killer Cells, Natural - cytology</subject><subject>Killer Cells, Natural - immunology</subject><subject>Major Histocompatibility Complex</subject><subject>MHC</subject><subject>Mice</subject><subject>mouse</subject><subject>Receptors, NK Cell Lectin-Like - genetics</subject><subject>Receptors, NK Cell Lectin-Like - immunology</subject><subject>Species Specificity</subject><subject>T-Lymphocytes, Cytotoxic - cytology</subject><subject>T-Lymphocytes, Cytotoxic - immunology</subject><subject>T-Lymphocytes, Helper-Inducer - cytology</subject><subject>T-Lymphocytes, Helper-Inducer - immunology</subject><issn>2059-2302</issn><issn>2059-2310</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMtOwzAURC0EolXpgh9AYckirR-1HW-QSqAPqRSEilhaTmzTiDSp4vDo32MIjWCBN77SnTmjOwCcIjhA_g1rVQwQ5pgcgC6GVISYIHjYzhB3QN-5LIGYCQ4ZF8egg1mEMGSwC87nRaFqE-S7zXZdZjpITZ67QBU6qNcmuJ3FJ-DIqtyZ_s_fA4-Tm1U8Cxd303k8XoTpiBISJtRaK7hAmGruo6zGyGKOUk0TklozYtanR8qOoMBaaO2XCYkSwiGPlB974LLhbl-TjdGpKepK5XJbZRtV7WSpMvl3U2Rr-Vy-Scpo5I_1gIsGkFalc5WxrRdB-VWV9FXJ76q89ux3WKvcF-MFw0bwnuVm9z9JrsbLPTJsHJmrzUfrUNWLZJxwKp-WUxlf0_tJxK7kA_kErXWBDA</recordid><startdate>201601</startdate><enddate>201601</enddate><creator>Robinette, M. L.</creator><creator>Colonna, M.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>201601</creationdate><title>Innate lymphoid cells and the MHC</title><author>Robinette, M. L. ; Colonna, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4533-b5fff979125d7269fd21f271cd5b3cfe46f7068af4092d9ddf27b38b37078a7b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>Antigens, CD - genetics</topic><topic>Antigens, CD - immunology</topic><topic>cytokines</topic><topic>Cytokines - genetics</topic><topic>Cytokines - immunology</topic><topic>Gene Expression</topic><topic>human</topic><topic>human leukocyte antigen</topic><topic>Humans</topic><topic>Immunity, Innate</topic><topic>innate</topic><topic>Innate lymphoid cells</topic><topic>Killer Cells, Natural - cytology</topic><topic>Killer Cells, Natural - immunology</topic><topic>Major Histocompatibility Complex</topic><topic>MHC</topic><topic>Mice</topic><topic>mouse</topic><topic>Receptors, NK Cell Lectin-Like - genetics</topic><topic>Receptors, NK Cell Lectin-Like - immunology</topic><topic>Species Specificity</topic><topic>T-Lymphocytes, Cytotoxic - cytology</topic><topic>T-Lymphocytes, Cytotoxic - immunology</topic><topic>T-Lymphocytes, Helper-Inducer - cytology</topic><topic>T-Lymphocytes, Helper-Inducer - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Robinette, M. L.</creatorcontrib><creatorcontrib>Colonna, M.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>HLA</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Robinette, M. L.</au><au>Colonna, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Innate lymphoid cells and the MHC</atitle><jtitle>HLA</jtitle><addtitle>HLA</addtitle><date>2016-01</date><risdate>2016</risdate><volume>87</volume><issue>1</issue><spage>5</spage><epage>11</epage><pages>5-11</pages><issn>2059-2302</issn><eissn>2059-2310</eissn><abstract>Innate lymphoid cells (ILCs) are a new class of immune cells that include natural killer (NK) cells and appear to be the innate counterparts to CD4+ helper T cells and CD8+ cytotoxic T cells based on developmental and functional similarities. Like T cells, both NK cells and other ILCs also show connections to the major histocompatibility complex (MHC). In human and mouse, NK cells recognize and respond to classical and nonclassical MHC I molecules as well as structural homologues, whereas mouse ILCs have recently been shown to express MHC II. We describe the history of MHC I recognition by NK cells and discuss emerging roles for MHC II expression by ILC subsets, making comparisons between both mouse and human when possible.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>26812060</pmid><doi>10.1111/tan.12723</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | HLA, 2016-01, Vol.87 (1), p.5-11 |
| issn | 2059-2302 2059-2310 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5658205 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals Antigens, CD - genetics Antigens, CD - immunology cytokines Cytokines - genetics Cytokines - immunology Gene Expression human human leukocyte antigen Humans Immunity, Innate innate Innate lymphoid cells Killer Cells, Natural - cytology Killer Cells, Natural - immunology Major Histocompatibility Complex MHC Mice mouse Receptors, NK Cell Lectin-Like - genetics Receptors, NK Cell Lectin-Like - immunology Species Specificity T-Lymphocytes, Cytotoxic - cytology T-Lymphocytes, Cytotoxic - immunology T-Lymphocytes, Helper-Inducer - cytology T-Lymphocytes, Helper-Inducer - immunology |
| title | Innate lymphoid cells and the MHC |
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