Functional connectivity alterations in a murine model of optic neuritis
The basis for neuronal dysfunction following inflammatory demyelination of the central nervous system (CNS) remains poorly understood. We characterized the network response to white matter injury in the anterior visual pathway using an experimental model of optic neuritis (ON), as ON is often an ear...
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| Veröffentlicht in: | Experimental neurology 2017-09, Vol.295, p.18-22 |
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| container_title | Experimental neurology |
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| creator | Wright, Patrick W. Archambault, Angela S. Peek, Stacey Bauer, Adam Q. Culican, Susan M. Ances, Beau M. Culver, Joseph P. Wu, Gregory F. |
| description | The basis for neuronal dysfunction following inflammatory demyelination of the central nervous system (CNS) remains poorly understood. We characterized the network response to white matter injury in the anterior visual pathway using an experimental model of optic neuritis (ON), as ON is often an early manifestation of immune-mediated CNS demyelination in multiple sclerosis (MS). Optical intrinsic signal imaging was performed before and after the induction of ON in mice to measure changes in cortical network functional connectivity. We observed a greater loss of connectivity between homotopic visual cortices in ON mice compared to controls. Further, decreases in homotopic visual cortex connectivity were associated with visual acuity loss in ON mice. These results demonstrate that network connectivity changes resulting from ON can be modeled in an experimental murine system. Future studies will identify the mechanisms that cause neuronal dysfunction due to white matter injury seen in MS. |
| doi_str_mv | 10.1016/j.expneurol.2017.05.004 |
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We characterized the network response to white matter injury in the anterior visual pathway using an experimental model of optic neuritis (ON), as ON is often an early manifestation of immune-mediated CNS demyelination in multiple sclerosis (MS). Optical intrinsic signal imaging was performed before and after the induction of ON in mice to measure changes in cortical network functional connectivity. We observed a greater loss of connectivity between homotopic visual cortices in ON mice compared to controls. Further, decreases in homotopic visual cortex connectivity were associated with visual acuity loss in ON mice. These results demonstrate that network connectivity changes resulting from ON can be modeled in an experimental murine system. Future studies will identify the mechanisms that cause neuronal dysfunction due to white matter injury seen in MS.</description><identifier>ISSN: 0014-4886</identifier><identifier>EISSN: 1090-2430</identifier><identifier>DOI: 10.1016/j.expneurol.2017.05.004</identifier><identifier>PMID: 28502610</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Demyelination ; Evoked Potentials, Visual ; Female ; Functional connectivity ; Image Processing, Computer-Assisted ; Male ; Mice ; Mice, Inbred C57BL ; Multiple sclerosis ; Multiple Sclerosis - physiopathology ; Neural Pathways - diagnostic imaging ; Neural Pathways - pathology ; Neuroimaging - methods ; Optic neuritis ; Optic Neuritis - diagnostic imaging ; Optic Neuritis - pathology ; Optical imaging ; Visual Acuity ; Visual cortex ; Visual Cortex - diagnostic imaging ; Visual Cortex - pathology ; Visual Pathways - diagnostic imaging ; Visual Pathways - pathology ; White Matter - pathology</subject><ispartof>Experimental neurology, 2017-09, Vol.295, p.18-22</ispartof><rights>2017 Elsevier Inc.</rights><rights>Copyright © 2017 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c475t-f1ca16e733e7d23ccdea2053722a306bb36818a00a3484e3a37dab4fa22a7e543</citedby><cites>FETCH-LOGICAL-c475t-f1ca16e733e7d23ccdea2053722a306bb36818a00a3484e3a37dab4fa22a7e543</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0014488617301218$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28502610$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wright, Patrick W.</creatorcontrib><creatorcontrib>Archambault, Angela S.</creatorcontrib><creatorcontrib>Peek, Stacey</creatorcontrib><creatorcontrib>Bauer, Adam Q.</creatorcontrib><creatorcontrib>Culican, Susan M.</creatorcontrib><creatorcontrib>Ances, Beau M.</creatorcontrib><creatorcontrib>Culver, Joseph P.</creatorcontrib><creatorcontrib>Wu, Gregory F.</creatorcontrib><title>Functional connectivity alterations in a murine model of optic neuritis</title><title>Experimental neurology</title><addtitle>Exp Neurol</addtitle><description>The basis for neuronal dysfunction following inflammatory demyelination of the central nervous system (CNS) remains poorly understood. We characterized the network response to white matter injury in the anterior visual pathway using an experimental model of optic neuritis (ON), as ON is often an early manifestation of immune-mediated CNS demyelination in multiple sclerosis (MS). Optical intrinsic signal imaging was performed before and after the induction of ON in mice to measure changes in cortical network functional connectivity. We observed a greater loss of connectivity between homotopic visual cortices in ON mice compared to controls. Further, decreases in homotopic visual cortex connectivity were associated with visual acuity loss in ON mice. These results demonstrate that network connectivity changes resulting from ON can be modeled in an experimental murine system. Future studies will identify the mechanisms that cause neuronal dysfunction due to white matter injury seen in MS.</description><subject>Animals</subject><subject>Demyelination</subject><subject>Evoked Potentials, Visual</subject><subject>Female</subject><subject>Functional connectivity</subject><subject>Image Processing, Computer-Assisted</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Multiple sclerosis</subject><subject>Multiple Sclerosis - physiopathology</subject><subject>Neural Pathways - diagnostic imaging</subject><subject>Neural Pathways - pathology</subject><subject>Neuroimaging - methods</subject><subject>Optic neuritis</subject><subject>Optic Neuritis - diagnostic imaging</subject><subject>Optic Neuritis - pathology</subject><subject>Optical imaging</subject><subject>Visual Acuity</subject><subject>Visual cortex</subject><subject>Visual Cortex - diagnostic imaging</subject><subject>Visual Cortex - pathology</subject><subject>Visual Pathways - diagnostic imaging</subject><subject>Visual Pathways - pathology</subject><subject>White Matter - pathology</subject><issn>0014-4886</issn><issn>1090-2430</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1P3DAQhq2qqCzQv0B97CVh_JHYe6mEUPmQkLjA2fI6k-JVYm_tZAX_Hq-WrsqJ02j0vvPOaB5CfjCoGbD2Yl3jyybgnOJQc2CqhqYGkF_IgsESKi4FfCULACYrqXV7TE5yXgPAUnL1jRxz3QBvGSzIzfUc3ORjsAN1MQQszdZPr9QOEya7UzL1gVo6zskHpGPscKCxp3EzeUd3N_jJ5zNy1Nsh4_f3ekqern8_Xt1W9w83d1eX95WTqpmqnjnLWlRCoOq4cK5Dy6ERinMroF2tRKuZtgBWSC1RWKE6u5K9LbrCRopT8mufu5lXI3YOw5TsYDbJjza9mmi9-agE_2z-xK1p2kZxCSXg53tAin9nzJMZfXY4DDZgnLNherlkoDWoYlV7q0sx54T9YQ0Ds8Ng1uaAwewwGGhMwVAmz_-_8jD37-_FcLk3YPnV1mMy2XkMDjufCgLTRf_pkjfsUJ_a</recordid><startdate>20170901</startdate><enddate>20170901</enddate><creator>Wright, Patrick W.</creator><creator>Archambault, Angela S.</creator><creator>Peek, Stacey</creator><creator>Bauer, Adam Q.</creator><creator>Culican, Susan M.</creator><creator>Ances, Beau M.</creator><creator>Culver, Joseph P.</creator><creator>Wu, Gregory F.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170901</creationdate><title>Functional connectivity alterations in a murine model of optic neuritis</title><author>Wright, Patrick W. ; Archambault, Angela S. ; Peek, Stacey ; Bauer, Adam Q. ; Culican, Susan M. ; Ances, Beau M. ; Culver, Joseph P. ; Wu, Gregory F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c475t-f1ca16e733e7d23ccdea2053722a306bb36818a00a3484e3a37dab4fa22a7e543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animals</topic><topic>Demyelination</topic><topic>Evoked Potentials, Visual</topic><topic>Female</topic><topic>Functional connectivity</topic><topic>Image Processing, Computer-Assisted</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Multiple sclerosis</topic><topic>Multiple Sclerosis - physiopathology</topic><topic>Neural Pathways - diagnostic imaging</topic><topic>Neural Pathways - pathology</topic><topic>Neuroimaging - methods</topic><topic>Optic neuritis</topic><topic>Optic Neuritis - diagnostic imaging</topic><topic>Optic Neuritis - pathology</topic><topic>Optical imaging</topic><topic>Visual Acuity</topic><topic>Visual cortex</topic><topic>Visual Cortex - diagnostic imaging</topic><topic>Visual Cortex - pathology</topic><topic>Visual Pathways - diagnostic imaging</topic><topic>Visual Pathways - pathology</topic><topic>White Matter - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wright, Patrick W.</creatorcontrib><creatorcontrib>Archambault, Angela S.</creatorcontrib><creatorcontrib>Peek, Stacey</creatorcontrib><creatorcontrib>Bauer, Adam Q.</creatorcontrib><creatorcontrib>Culican, Susan M.</creatorcontrib><creatorcontrib>Ances, Beau M.</creatorcontrib><creatorcontrib>Culver, Joseph P.</creatorcontrib><creatorcontrib>Wu, Gregory F.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Experimental neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wright, Patrick W.</au><au>Archambault, Angela S.</au><au>Peek, Stacey</au><au>Bauer, Adam Q.</au><au>Culican, Susan M.</au><au>Ances, Beau M.</au><au>Culver, Joseph P.</au><au>Wu, Gregory F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Functional connectivity alterations in a murine model of optic neuritis</atitle><jtitle>Experimental neurology</jtitle><addtitle>Exp Neurol</addtitle><date>2017-09-01</date><risdate>2017</risdate><volume>295</volume><spage>18</spage><epage>22</epage><pages>18-22</pages><issn>0014-4886</issn><eissn>1090-2430</eissn><abstract>The basis for neuronal dysfunction following inflammatory demyelination of the central nervous system (CNS) remains poorly understood. We characterized the network response to white matter injury in the anterior visual pathway using an experimental model of optic neuritis (ON), as ON is often an early manifestation of immune-mediated CNS demyelination in multiple sclerosis (MS). Optical intrinsic signal imaging was performed before and after the induction of ON in mice to measure changes in cortical network functional connectivity. We observed a greater loss of connectivity between homotopic visual cortices in ON mice compared to controls. Further, decreases in homotopic visual cortex connectivity were associated with visual acuity loss in ON mice. These results demonstrate that network connectivity changes resulting from ON can be modeled in an experimental murine system. Future studies will identify the mechanisms that cause neuronal dysfunction due to white matter injury seen in MS.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>28502610</pmid><doi>10.1016/j.expneurol.2017.05.004</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Demyelination Evoked Potentials, Visual Female Functional connectivity Image Processing, Computer-Assisted Male Mice Mice, Inbred C57BL Multiple sclerosis Multiple Sclerosis - physiopathology Neural Pathways - diagnostic imaging Neural Pathways - pathology Neuroimaging - methods Optic neuritis Optic Neuritis - diagnostic imaging Optic Neuritis - pathology Optical imaging Visual Acuity Visual cortex Visual Cortex - diagnostic imaging Visual Cortex - pathology Visual Pathways - diagnostic imaging Visual Pathways - pathology White Matter - pathology |
| title | Functional connectivity alterations in a murine model of optic neuritis |
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