Non-Additive Effects of Repetitive Administration of Lipoplexes in Immunocompetent Mice

Repetitive administration is routinely used to maintain therapeutic drug levels, but previous studies have documented an accelerated blood clearance of some lipid-based delivery systems under these conditions. To assess the effect of repetitive administration, non-PEGylated lipoplexes (+/− = 0.5) we...

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Veröffentlicht in:	Journal of pharmaceutical sciences 2016-11, Vol.106 (3), p.872-881
Hauptverfasser:	Betker, Jamie L., Anchordoquy, Thomas J.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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