Distinct oligomerization and fibrillization dynamics of amyloid core sequences of amyloid-beta and islet amyloid polypeptide

A direct observation of amyloid aggregation from isolated peptides to cross-β fibrils is crucial for understanding the nucleation-dependence process, but the corresponding macroscopic timescales impose a major computational challenge. Using rapid all-atom discrete molecular dynamics simulations, we...

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Veröffentlicht in:	Physical chemistry chemical physics : PCCP 2017-10, Vol.19 (41), p.28414-28423
Hauptverfasser:	Sun, Yunxiang, Wang, Bo, Ge, Xinwei, Ding, Feng
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyloid - chemistry Hydrophobic and Hydrophilic Interactions Islet Amyloid Polypeptide - chemistry Protein Conformation
Online-Zugang:	Volltext
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