Exploratory Population PK Analysis of Dupilumab, a Fully Human Monoclonal Antibody Against IL‐4Rα, in Atopic Dermatitis Patients and Normal Volunteers

An exploratory population pharmacokinetic model for functional dupilumab was developed. Data from healthy volunteers and patients with atopic dermatitis (AD) receiving intravenous or subcutaneous doses were integrated. The data included 197 participants (2,518 measurements of dupilumab in serum) fro...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	CPT: pharmacometrics and systems pharmacology 2016-11, Vol.5 (11), p.617-624
Hauptverfasser:	Kovalenko, P, DiCioccio, AT, Davis, JD, Li, M, Ardeleanu, M, Graham, NMH, Soltys, R
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intravenous Adult Antibodies, Monoclonal - administration & dosage Antibodies, Monoclonal - pharmacokinetics Binding sites Biological Availability Clinical Trials, Phase I as Topic Clinical Trials, Phase II as Topic Cytokines Dermatitis Dermatitis, Atopic - drug therapy Dermatitis, Atopic - metabolism Dose-Response Relationship, Drug Drug dosages Eczema Female Gender Humans Immunotherapy Injections, Subcutaneous Male Metabolic Clearance Rate Monoclonal antibodies Original Pharmaceuticals Population Studies Treatment Outcome
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!