Acute respiratory distress syndrome: insights gained from clinical and translational research
Acute lung injury and its more severe form acute respiratory distress syndrome (ARDS) are characterized by diffuse impairment of alveolocapillary membrane in the settings of different predisposing conditions such as sepsis, trauma and shock. Many intrahospital exposures, including aspiration, delaye...
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| Veröffentlicht in: | Biomolecules & biomedicine 2009-10, Vol.9 Suppl 1 (1), p.S59-S68 |
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| container_title | Biomolecules & biomedicine |
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| creator | Kojicic, Marija Festic, Emir Gajic, Ognjen |
| description | Acute lung injury and its more severe form acute respiratory distress syndrome (ARDS) are characterized by diffuse impairment of alveolocapillary membrane in the settings of different predisposing conditions such as sepsis, trauma and shock. Many intrahospital exposures, including aspiration, delayed resuscitation, high tidal volume mechanical ventilation and non critical use of transfusions may contribute or worsen ARDS. Therapy is targeted to treatment of predisposing condition, life supportive measures and prevention of nosocomial complications. Rigorous adherence to lung-protective mechanical ventilation is critical to prevent ventilator induced lung injury and decrease mortality. Although survival of ARDS patients has improved in the last decades ARDS mortality rates are still high and survivors encounter significant physical and psychological impairments. |
| doi_str_mv | 10.17305/bjbms.2009.2764 |
| format | Article |
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| ispartof | Biomolecules & biomedicine, 2009-10, Vol.9 Suppl 1 (1), p.S59-S68 |
| issn | 1512-8601 2831-0896 1840-4812 2831-090X |
| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Adrenal Cortex Hormones - therapeutic use adult Humans mechanical ventilation Prognosis pulmonary edema Respiration, Artificial Respiratory distress syndrome Respiratory Distress Syndrome - diagnosis Respiratory Distress Syndrome - etiology Respiratory Distress Syndrome - therapy Translational Research, Biomedical |
| title | Acute respiratory distress syndrome: insights gained from clinical and translational research |
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