Cellular hormetic response to 27-hydroxycholesterol promotes neuroprotection through AICD induction of MAST4 abundance and kinase activity

The function of the amyloid precursor protein (APP) in brain health remains unclear. This study elucidated a novel cytoprotective signaling pathway initiated by the APP transcriptionally active intracellular domain (AICD) in response to 27-hydroxycholesterol (27OHC), an oxidized cholesterol metaboli...

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Veröffentlicht in:	Scientific reports 2017-10, Vol.7 (1), p.13898-11, Article 13898
Hauptverfasser:	Gongol, Brendan, Marin, Traci L., Jeppson, John D., Mayagoitia, Karina, Shin, Samuel, Sanchez, Nicholas, Kirsch, Wolff M., Vinters, Harry V., Wilson, Christopher G., Ghribi, Othman, Soriano, Salvador
Format:	Artikel
Sprache:	eng
Schlagworte:	38/1 38/109 38/61 38/70 38/89 631/378 631/378/340 631/378/87 96/106 Alzheimer's disease Amyloid precursor protein Cell survival Cholesterol Dementia disorders FOXO1 protein Frontotemporal dementia Gene silencing Humanities and Social Sciences Intracellular signalling Kinases Metabolites multidisciplinary Neurodegeneration Neurodegenerative diseases Neuroprotection Palmitic acid Protein-serine/threonine kinase Science Science (multidisciplinary) Signal transduction
Online-Zugang:	Volltext
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