Dopamine D2 Receptors in the Paraventricular Thalamus Attenuate Cocaine Locomotor Sensitization

Alterations in thalamic dopamine (DA) or DA D2 receptors (D2Rs) have been measured in drug addiction and schizophrenia, but the relevance of thalamic D2Rs for behavior is largely unknown. Using hybridization and mice expressing green fluorescent protein (GFP) under the promoter, we found that D2R ex...

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Veröffentlicht in:	eNeuro 2017-09, Vol.4 (5), p.ENEURO.0227-17.2017
Hauptverfasser:	Clark, Abigail M, Leroy, Felix, Martyniuk, Kelly M, Feng, Wendy, McManus, Erika, Bailey, Matthew R, Javitch, Jonathan A, Balsam, Peter D, Kellendonk, Christoph
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cocaine - pharmacology Dopamine Agonists - pharmacology Dopamine Antagonists - pharmacology Dopamine Uptake Inhibitors - pharmacology Dose-Response Relationship, Drug Fear - drug effects Female Locomotion - drug effects Locomotion - genetics Male Maze Learning - drug effects Membrane Potentials - drug effects Membrane Potentials - genetics Mice Mice, Inbred C57BL Mice, Transgenic Midline Thalamic Nuclei - drug effects New Research Quinpirole - pharmacology Receptors, Dopamine D2 - genetics Receptors, Dopamine D2 - metabolism Sulpiride - pharmacology Transduction, Genetic
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