Desulfation of Heparan Sulfate by Sulf1 and Sulf2 Is Required for Corticospinal Tract Formation

Heparan sulfate (HS) has been implicated in a wide range of cell signaling. Here we report a novel mechanism in which extracellular removal of 6- O -sulfate groups from HS by the endosulfatases, Sulf1 and Sulf2, is essential for axon guidance during development. In Sulf1/ 2 double knockout (DKO) mic...

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Veröffentlicht in:	Scientific reports 2017-10, Vol.7 (1), p.13847-14, Article 13847
Hauptverfasser:	Okada, Takuya, Keino-Masu, Kazuko, Nagamine, Satoshi, Kametani, Fuyuki, Ohto, Tatsuyuki, Hasegawa, Masato, van Kuppevelt, Toin H., Kunita, Satoshi, Takahashi, Satoru, Masu, Masayuki
Format:	Artikel
Sprache:	eng
Schlagworte:	13 14 14/19 42 42/109 42/35 45 59 631/378/2571/2576 631/45/221 631/80/221 64 64/60 82 82/29 82/51 96 96/63 Animals Axon Guidance Axonogenesis Electroporation Glial cells Heparan sulfate Heparitin Sulfate - chemistry Heparitin Sulfate - metabolism Humanities and Social Sciences Hypothalamus Mesencephalon Mice Mice, Inbred C57BL Mice, Knockout multidisciplinary Phenotype Proteomics Pyramidal tracts Pyramidal Tracts - metabolism Pyramidal Tracts - pathology Radial glial cells Science Science (multidisciplinary) Signal Transduction Spinal Cord Injuries - metabolism Spinal Cord Injuries - pathology Sulfatases - physiology Sulfates Sulfates - chemistry Sulfates - metabolism Sulfotransferases - physiology Ventricle Ventricles (cerebral)
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