Antibiotic susceptibility profiles among Campylobacter isolates obtained from international travelers between 2007 and 2014
Campylobacter infection is a common cause of diarrhea among international travelers. We studied antibiotic resistance patterns among Campylobacter isolates obtained from international travelers according to travel destination. Three collections of isolates obtained from international travelers betwe...
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| Veröffentlicht in: | European journal of clinical microbiology & infectious diseases 2017-11, Vol.36 (11), p.2101-2107 |
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| creator | Post, A. Martiny, D. van Waterschoot, N. Hallin, M. Maniewski, U. Bottieau, E. Van Esbroeck, M. Vlieghe, E. Ombelet, S. Vandenberg, O. Jacobs, J. |
| description | Campylobacter
infection is a common cause of diarrhea among international travelers. We studied antibiotic resistance patterns among
Campylobacter
isolates obtained from international travelers according to travel destination. Three collections of isolates obtained from international travelers between 2007 and 2014 (Institute of Tropical Medicine, the “Laboratoire Hospitalier Universitaire de Bruxelles “and the Belgian National Reference Centre for
Campylobacter
) were used. Isolates were tested for minimal inhibitory concentration (MIC) values (E-test macromethod) for fluoroquinolones, macrolides, tetracyclines, amoxicillin–clavulanic acid, and meropenem. Single isolates from 261 travelers were available; median (IQR) age was 25.4 (4–42) years, 85.8% were symptomatic (information for 224 patients available). Overall resistance to ciprofloxacin was 60.9%, ranging from 50.8% in Africa to 75.0% in Asia. Resistance to erythromycin was 4.6%, with the highest rate observed for Southern Asia (15.2%, seven isolates, six of them recovered from patients returning from India). A total of 126 isolates (48.3%) were resistant to tetracycline. No resistance to amoxicillin–clavulanic acid or meropenem was detected. Ciprofloxacin resistance tended to increase over time (53.9% in 2007 versus 72.2% in 2014), erythromycin resistance remained stable (median annual resistance 4.2%). Most (86.2%) ciprofloxacin-resistant isolates had MIC values ≥32 mg/l, and all erythromycin-resistant isolates had MIC values ≥256 mg/l. Co-resistance to ciprofloxacin and erythromycin was observed in 11 (4.2%) isolates, seven of which came from Southern Asia. Among all regions of travel, more than half of
Campylobacter
isolates were resistant to ciprofloxacin. Overall resistance to erythromycin was below 5% but reached 15.2% in Southern Asia. |
| doi_str_mv | 10.1007/s10096-017-3032-6 |
| format | Article |
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infection is a common cause of diarrhea among international travelers. We studied antibiotic resistance patterns among
Campylobacter
isolates obtained from international travelers according to travel destination. Three collections of isolates obtained from international travelers between 2007 and 2014 (Institute of Tropical Medicine, the “Laboratoire Hospitalier Universitaire de Bruxelles “and the Belgian National Reference Centre for
Campylobacter
) were used. Isolates were tested for minimal inhibitory concentration (MIC) values (E-test macromethod) for fluoroquinolones, macrolides, tetracyclines, amoxicillin–clavulanic acid, and meropenem. Single isolates from 261 travelers were available; median (IQR) age was 25.4 (4–42) years, 85.8% were symptomatic (information for 224 patients available). Overall resistance to ciprofloxacin was 60.9%, ranging from 50.8% in Africa to 75.0% in Asia. Resistance to erythromycin was 4.6%, with the highest rate observed for Southern Asia (15.2%, seven isolates, six of them recovered from patients returning from India). A total of 126 isolates (48.3%) were resistant to tetracycline. No resistance to amoxicillin–clavulanic acid or meropenem was detected. Ciprofloxacin resistance tended to increase over time (53.9% in 2007 versus 72.2% in 2014), erythromycin resistance remained stable (median annual resistance 4.2%). Most (86.2%) ciprofloxacin-resistant isolates had MIC values ≥32 mg/l, and all erythromycin-resistant isolates had MIC values ≥256 mg/l. Co-resistance to ciprofloxacin and erythromycin was observed in 11 (4.2%) isolates, seven of which came from Southern Asia. Among all regions of travel, more than half of
Campylobacter
isolates were resistant to ciprofloxacin. Overall resistance to erythromycin was below 5% but reached 15.2% in Southern Asia.</description><identifier>ISSN: 0934-9723</identifier><identifier>EISSN: 1435-4373</identifier><identifier>DOI: 10.1007/s10096-017-3032-6</identifier><identifier>PMID: 28623550</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Acid resistance ; Adolescent ; Adult ; Amoxicillin ; Amoxicillin-Potassium Clavulanate Combination - pharmacology ; Anti-Bacterial Agents - pharmacology ; Antibiotic resistance ; Antibiotics ; Biomedical and Life Sciences ; Biomedicine ; Campylobacter ; Campylobacter - classification ; Campylobacter - drug effects ; Campylobacter - isolation & purification ; Campylobacter Infections - drug therapy ; Campylobacter Infections - microbiology ; Child ; Child, Preschool ; Ciprofloxacin ; Ciprofloxacin - pharmacology ; Clavulanic acid ; Communicable Diseases, Imported - drug therapy ; Communicable Diseases, Imported - microbiology ; Diarrhea ; Drug Resistance, Multiple, Bacterial ; Erythromycin ; Erythromycin - pharmacology ; Female ; Fluoroquinolones ; Humans ; Internal Medicine ; Male ; Medical Microbiology ; Meropenem ; Microbial Sensitivity Tests ; Minimum inhibitory concentration ; Original ; Original Article ; Patients ; Tetracyclines ; Thienamycins - pharmacology ; Travel ; Young Adult</subject><ispartof>European journal of clinical microbiology & infectious diseases, 2017-11, Vol.36 (11), p.2101-2107</ispartof><rights>The Author(s) 2017</rights><rights>European Journal of Clinical Microbiology & Infectious Diseases is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c536t-98cb3b1ae5745875a59948e6db829d93168c822fed25e6afcd9eb89f3500384a3</citedby><cites>FETCH-LOGICAL-c536t-98cb3b1ae5745875a59948e6db829d93168c822fed25e6afcd9eb89f3500384a3</cites><orcidid>0000-0002-0471-8250</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10096-017-3032-6$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10096-017-3032-6$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28623550$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Post, A.</creatorcontrib><creatorcontrib>Martiny, D.</creatorcontrib><creatorcontrib>van Waterschoot, N.</creatorcontrib><creatorcontrib>Hallin, M.</creatorcontrib><creatorcontrib>Maniewski, U.</creatorcontrib><creatorcontrib>Bottieau, E.</creatorcontrib><creatorcontrib>Van Esbroeck, M.</creatorcontrib><creatorcontrib>Vlieghe, E.</creatorcontrib><creatorcontrib>Ombelet, S.</creatorcontrib><creatorcontrib>Vandenberg, O.</creatorcontrib><creatorcontrib>Jacobs, J.</creatorcontrib><title>Antibiotic susceptibility profiles among Campylobacter isolates obtained from international travelers between 2007 and 2014</title><title>European journal of clinical microbiology & infectious diseases</title><addtitle>Eur J Clin Microbiol Infect Dis</addtitle><addtitle>Eur J Clin Microbiol Infect Dis</addtitle><description>Campylobacter
infection is a common cause of diarrhea among international travelers. We studied antibiotic resistance patterns among
Campylobacter
isolates obtained from international travelers according to travel destination. Three collections of isolates obtained from international travelers between 2007 and 2014 (Institute of Tropical Medicine, the “Laboratoire Hospitalier Universitaire de Bruxelles “and the Belgian National Reference Centre for
Campylobacter
) were used. Isolates were tested for minimal inhibitory concentration (MIC) values (E-test macromethod) for fluoroquinolones, macrolides, tetracyclines, amoxicillin–clavulanic acid, and meropenem. Single isolates from 261 travelers were available; median (IQR) age was 25.4 (4–42) years, 85.8% were symptomatic (information for 224 patients available). Overall resistance to ciprofloxacin was 60.9%, ranging from 50.8% in Africa to 75.0% in Asia. Resistance to erythromycin was 4.6%, with the highest rate observed for Southern Asia (15.2%, seven isolates, six of them recovered from patients returning from India). A total of 126 isolates (48.3%) were resistant to tetracycline. No resistance to amoxicillin–clavulanic acid or meropenem was detected. Ciprofloxacin resistance tended to increase over time (53.9% in 2007 versus 72.2% in 2014), erythromycin resistance remained stable (median annual resistance 4.2%). Most (86.2%) ciprofloxacin-resistant isolates had MIC values ≥32 mg/l, and all erythromycin-resistant isolates had MIC values ≥256 mg/l. Co-resistance to ciprofloxacin and erythromycin was observed in 11 (4.2%) isolates, seven of which came from Southern Asia. Among all regions of travel, more than half of
Campylobacter
isolates were resistant to ciprofloxacin. Overall resistance to erythromycin was below 5% but reached 15.2% in Southern Asia.</description><subject>Acid resistance</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Amoxicillin</subject><subject>Amoxicillin-Potassium Clavulanate Combination - pharmacology</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibiotic resistance</subject><subject>Antibiotics</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Campylobacter</subject><subject>Campylobacter - classification</subject><subject>Campylobacter - drug effects</subject><subject>Campylobacter - isolation & purification</subject><subject>Campylobacter Infections - drug therapy</subject><subject>Campylobacter Infections - microbiology</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Ciprofloxacin</subject><subject>Ciprofloxacin - pharmacology</subject><subject>Clavulanic acid</subject><subject>Communicable Diseases, Imported - drug therapy</subject><subject>Communicable Diseases, Imported - microbiology</subject><subject>Diarrhea</subject><subject>Drug Resistance, Multiple, Bacterial</subject><subject>Erythromycin</subject><subject>Erythromycin - pharmacology</subject><subject>Female</subject><subject>Fluoroquinolones</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Medical Microbiology</subject><subject>Meropenem</subject><subject>Microbial Sensitivity Tests</subject><subject>Minimum inhibitory concentration</subject><subject>Original</subject><subject>Original Article</subject><subject>Patients</subject><subject>Tetracyclines</subject><subject>Thienamycins - pharmacology</subject><subject>Travel</subject><subject>Young Adult</subject><issn>0934-9723</issn><issn>1435-4373</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kUuLFDEUhYMoTs_oD3AjATduSvOovDbC0KgjDLjRdUhV3WozpJIySc_Q-OdN0-MwCm7y4Hz35OYehF5R8o4Sot6XthrZEao6Tjjr5BO0oT0XXc8Vf4o2xPC-M4rxM3Reyg1pNVqp5-iMacm4EGSDfl3G6gefqh9x2ZcR1uM1-HrAa06zD1CwW1Lc4a1b1kNIgxsrZOxLCq42MQ3V-QgTnnNasI9NjK76FF3ANbtbCJALHqDeAUTMWgvYxakdaP8CPZtdKPDyfr9A3z99_La96q6_fv6yvbzuRsFl7YweBz5QB0L1QivhhDG9BjkNmpnJcCr1qBmbYWICpJvHycCgzcwFIVz3jl-gDyffdT8sMI0QW2PBrtkvLh9sct7-rUT_w-7SrRVScMVYM3h7b5DTzz2UahffRhWCi5D2xVJDiSZESNLQN_-gN2nfJhKOlOgZ10yoRtETNeZUSob5oRlK7DFae4rWtmjtMVorW83rx794qPiTZQPYCShNijvIj57-r-tv92Cwtw</recordid><startdate>20171101</startdate><enddate>20171101</enddate><creator>Post, A.</creator><creator>Martiny, D.</creator><creator>van Waterschoot, N.</creator><creator>Hallin, M.</creator><creator>Maniewski, U.</creator><creator>Bottieau, E.</creator><creator>Van Esbroeck, M.</creator><creator>Vlieghe, E.</creator><creator>Ombelet, S.</creator><creator>Vandenberg, O.</creator><creator>Jacobs, J.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-0471-8250</orcidid></search><sort><creationdate>20171101</creationdate><title>Antibiotic susceptibility profiles among Campylobacter isolates obtained from international travelers between 2007 and 2014</title><author>Post, A. ; Martiny, D. ; van Waterschoot, N. ; Hallin, M. ; Maniewski, U. ; Bottieau, E. ; Van Esbroeck, M. ; Vlieghe, E. ; Ombelet, S. ; Vandenberg, O. ; Jacobs, J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c536t-98cb3b1ae5745875a59948e6db829d93168c822fed25e6afcd9eb89f3500384a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Acid resistance</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Amoxicillin</topic><topic>Amoxicillin-Potassium Clavulanate Combination - pharmacology</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Antibiotic resistance</topic><topic>Antibiotics</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Campylobacter</topic><topic>Campylobacter - classification</topic><topic>Campylobacter - drug effects</topic><topic>Campylobacter - isolation & purification</topic><topic>Campylobacter Infections - drug therapy</topic><topic>Campylobacter Infections - microbiology</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Ciprofloxacin</topic><topic>Ciprofloxacin - pharmacology</topic><topic>Clavulanic acid</topic><topic>Communicable Diseases, Imported - drug therapy</topic><topic>Communicable Diseases, Imported - microbiology</topic><topic>Diarrhea</topic><topic>Drug Resistance, Multiple, Bacterial</topic><topic>Erythromycin</topic><topic>Erythromycin - pharmacology</topic><topic>Female</topic><topic>Fluoroquinolones</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Male</topic><topic>Medical Microbiology</topic><topic>Meropenem</topic><topic>Microbial Sensitivity Tests</topic><topic>Minimum inhibitory concentration</topic><topic>Original</topic><topic>Original Article</topic><topic>Patients</topic><topic>Tetracyclines</topic><topic>Thienamycins - pharmacology</topic><topic>Travel</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Post, A.</creatorcontrib><creatorcontrib>Martiny, D.</creatorcontrib><creatorcontrib>van Waterschoot, N.</creatorcontrib><creatorcontrib>Hallin, M.</creatorcontrib><creatorcontrib>Maniewski, U.</creatorcontrib><creatorcontrib>Bottieau, E.</creatorcontrib><creatorcontrib>Van Esbroeck, M.</creatorcontrib><creatorcontrib>Vlieghe, E.</creatorcontrib><creatorcontrib>Ombelet, S.</creatorcontrib><creatorcontrib>Vandenberg, O.</creatorcontrib><creatorcontrib>Jacobs, J.</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>European journal of clinical microbiology & infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Post, A.</au><au>Martiny, D.</au><au>van Waterschoot, N.</au><au>Hallin, M.</au><au>Maniewski, U.</au><au>Bottieau, E.</au><au>Van Esbroeck, M.</au><au>Vlieghe, E.</au><au>Ombelet, S.</au><au>Vandenberg, O.</au><au>Jacobs, J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antibiotic susceptibility profiles among Campylobacter isolates obtained from international travelers between 2007 and 2014</atitle><jtitle>European journal of clinical microbiology & infectious diseases</jtitle><stitle>Eur J Clin Microbiol Infect Dis</stitle><addtitle>Eur J Clin Microbiol Infect Dis</addtitle><date>2017-11-01</date><risdate>2017</risdate><volume>36</volume><issue>11</issue><spage>2101</spage><epage>2107</epage><pages>2101-2107</pages><issn>0934-9723</issn><eissn>1435-4373</eissn><abstract>Campylobacter
infection is a common cause of diarrhea among international travelers. We studied antibiotic resistance patterns among
Campylobacter
isolates obtained from international travelers according to travel destination. Three collections of isolates obtained from international travelers between 2007 and 2014 (Institute of Tropical Medicine, the “Laboratoire Hospitalier Universitaire de Bruxelles “and the Belgian National Reference Centre for
Campylobacter
) were used. Isolates were tested for minimal inhibitory concentration (MIC) values (E-test macromethod) for fluoroquinolones, macrolides, tetracyclines, amoxicillin–clavulanic acid, and meropenem. Single isolates from 261 travelers were available; median (IQR) age was 25.4 (4–42) years, 85.8% were symptomatic (information for 224 patients available). Overall resistance to ciprofloxacin was 60.9%, ranging from 50.8% in Africa to 75.0% in Asia. Resistance to erythromycin was 4.6%, with the highest rate observed for Southern Asia (15.2%, seven isolates, six of them recovered from patients returning from India). A total of 126 isolates (48.3%) were resistant to tetracycline. No resistance to amoxicillin–clavulanic acid or meropenem was detected. Ciprofloxacin resistance tended to increase over time (53.9% in 2007 versus 72.2% in 2014), erythromycin resistance remained stable (median annual resistance 4.2%). Most (86.2%) ciprofloxacin-resistant isolates had MIC values ≥32 mg/l, and all erythromycin-resistant isolates had MIC values ≥256 mg/l. Co-resistance to ciprofloxacin and erythromycin was observed in 11 (4.2%) isolates, seven of which came from Southern Asia. Among all regions of travel, more than half of
Campylobacter
isolates were resistant to ciprofloxacin. Overall resistance to erythromycin was below 5% but reached 15.2% in Southern Asia.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>28623550</pmid><doi>10.1007/s10096-017-3032-6</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-0471-8250</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | European journal of clinical microbiology & infectious diseases, 2017-11, Vol.36 (11), p.2101-2107 |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Acid resistance Adolescent Adult Amoxicillin Amoxicillin-Potassium Clavulanate Combination - pharmacology Anti-Bacterial Agents - pharmacology Antibiotic resistance Antibiotics Biomedical and Life Sciences Biomedicine Campylobacter Campylobacter - classification Campylobacter - drug effects Campylobacter - isolation & purification Campylobacter Infections - drug therapy Campylobacter Infections - microbiology Child Child, Preschool Ciprofloxacin Ciprofloxacin - pharmacology Clavulanic acid Communicable Diseases, Imported - drug therapy Communicable Diseases, Imported - microbiology Diarrhea Drug Resistance, Multiple, Bacterial Erythromycin Erythromycin - pharmacology Female Fluoroquinolones Humans Internal Medicine Male Medical Microbiology Meropenem Microbial Sensitivity Tests Minimum inhibitory concentration Original Original Article Patients Tetracyclines Thienamycins - pharmacology Travel Young Adult |
| title | Antibiotic susceptibility profiles among Campylobacter isolates obtained from international travelers between 2007 and 2014 |
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