Severe steroid-resistant anti-PD1 T-cell checkpoint inhibitor-induced hepatotoxicity driven by biliary injury

IntroductionHepatotoxicity from T-cell checkpoint blockade is an increasingly common immune-related adverse event, but remains poorly characterised and can be challenging to manage. Such toxicity is generally considered to resemble autoimmune hepatitis, although this assumption is extrapolated from...

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Veröffentlicht in:	ESMO open 2017, Vol.2 (4), p.e000268, Article e000268
Hauptverfasser:	Doherty, Gary Joseph, Duckworth, Adam M, Davies, Susan E, Mells, George F, Brais, Rebecca, Harden, Susan V, Parkinson, Christine A, Corrie, Pippa G
Format:	Artikel
Sprache:	eng
Schlagworte:	biliary injury hepatotoxicity immunotherapy nivolumab Original Research pembrolizumab
Online-Zugang:	Volltext
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