Use of the relative release index for histamine in LAD2 cells to evaluate the potential anaphylactoid effects of drugs

Anaphylactoid reactions are common clinical acute adverse drug reactions that can exacerbate a patient’s condition and produce effects that may become life-threatening. Therefore, it is important to establish a novel method to evaluate drugs for anaphylactoid reactions. In this study, we developed a...

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Veröffentlicht in:	Scientific reports 2017-10, Vol.7 (1), p.13714-9, Article 13714
Hauptverfasser:	Han, Shengli, Lv, Yanni, Kong, Liyun, Che, Delu, Liu, Rui, Fu, Jia, Cao, Jiao, Wang, Jue, Wang, Cheng, He, Huaizhen, Zhang, Tao, Dong, Xinzhong, He, Langchong
Format:	Artikel
Sprache:	eng
Schlagworte:	13/51 631/250 692/699 82 82/16 82/58 96 Allergens Anaphylactoid reactions Anaphylaxis - chemically induced Anaphylaxis - metabolism Animals Anti-Infective Agents - adverse effects Baicalin Calcium - metabolism Calcium influx Cations, Divalent - metabolism Cell Line Chromatography, Liquid - methods Ciprofloxacin Drug development Histamine Histamine - analysis Histamine - metabolism Humanities and Social Sciences Humans Liquid chromatography Lomefloxacin Male Mass spectrometry Mass spectroscopy Mast Cells - drug effects Mast Cells - metabolism Mice, Inbred C57BL Moxifloxacin multidisciplinary Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Norfloxacin Random Allocation Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - metabolism Receptors, Neuropeptide - genetics Receptors, Neuropeptide - metabolism Science Science (multidisciplinary) Side effects Tandem Mass Spectrometry - methods
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