CRISPR-Cas9–based treatment of myocilin-associated glaucoma

Primary open-angle glaucoma (POAG) is a leading cause of irreversible vision loss worldwide, with elevated intraocular pressure (IOP) a major risk factor. Myocilin (MYOC) dominant gain-of-function mutations have been reported in ∼4% of POAG cases. MYOC mutations result in protein misfolding, leading...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2017-10, Vol.114 (42), p.11199-11204
Hauptverfasser:	Jain, Ankur, Zode, Gulab, Kasetti, Ramesh B., Ran, Fei A., Yan, Winston, Sharma, Tasneem P., Bugge, Kevin, Searby, Charles C., Fingert, John H., Zhang, Feng, Clark, Abbot F., Sheffield, Val C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Sciences Cell culture Cell Line CRISPR CRISPR-Cas Systems Cytoskeletal Proteins - genetics Damage prevention Editing Endoplasmic reticulum Eye Proteins - genetics Feasibility studies Gene Editing Genetic Therapy - methods Genomes Glaucoma Glaucoma, Open-Angle - genetics Glaucoma, Open-Angle - therapy Glycoproteins - genetics Humans In Vitro Techniques Intraocular pressure Mice Mutation Organ culture Protein folding Risk factors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!