Prediction of sustained fetal toxicity induced by ketoprofen based on PK/PD analysis using human placental perfusion and rat toxicity data

Aim We encountered a case of fetal toxicity due to ductus arteriosus (DA) constriction in a 36‐week pregnant woman who had applied multiple ketoprofen patches. The aim of the present study was to present the case and develop a model to predict quantitatively the fetal toxicity risk of transdermal ad...

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Veröffentlicht in:	British journal of clinical pharmacology 2017-11, Vol.83 (11), p.2503-2516
Hauptverfasser:	Tanaka, Shingo, Kanagawa, Takeshi, Momma, Kazuo, Hori, Satoko, Satoh, Hiroki, Nagamatsu, Takeshi, Fujii, Tomoyuki, Kimura, Tadashi, Sawada, Yasufumi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Animals Anti-Inflammatory Agents, Non-Steroidal - adverse effects Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics Antipyrine - pharmacokinetics Biomarkers, Pharmacological - metabolism constriction of the ductus arteriosus Constriction, Pathologic - chemically induced Drugs in Pregnancy and Lactation Ductus Arteriosus - drug effects Ductus Arteriosus - pathology Female fetal toxicity Humans ketoprofen Ketoprofen - adverse effects Ketoprofen - pharmacokinetics local dermatological formulation Low Back Pain - drug therapy Maternal-Fetal Exchange - drug effects Models, Animal Models, Biological Perfusion - methods PK/PD analysis Placenta - metabolism Pregnancy Pregnancy Complications - drug therapy Pregnancy Trimester, Third - drug effects Rats Rats, Wistar Risk Assessment - methods Transdermal Patch - adverse effects
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