Upregulation of neuronal kynurenine 3-monooxygenase mediates depression-like behavior in a mouse model of neuropathic pain

•Nerve injury induces depression and upregulates kynurenine 3-monoxygenase (KMO) expression and activity.•KMO is upregulated in neurons in the contralateral hippocampus and not in microglia.•Upregulation of KMO is downstream of cerebral interleukin-1 signaling.•Inhibition of brain KMO reverses depre...

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Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2017-11, Vol.66, p.94-102
Hauptverfasser:	Laumet, Geoffroy, Zhou, Wenjun, Dantzer, Robert, Edralin, Jules D., Huo, XiaoJiao, Budac, David P., O'Connor, Jason C., Lee, Anna W., Heijnen, Cobi J., Kavelaars, Annemieke
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Comorbidity Depression Depression - complications Depression - enzymology Disease Models, Animal Hippocampus Hippocampus - enzymology Hyperalgesia - complications Hyperalgesia - enzymology Interleukin-1 Interleukin-1 - metabolism Kynurenine 3-monooxygenase Kynurenine 3-Monooxygenase - genetics Kynurenine 3-Monooxygenase - metabolism Kynurenine pathway Male Mice, Inbred C57BL Microglia - enzymology Neuralgia - complications Neuralgia - enzymology Neurons - enzymology Pain Peripheral Nerve Injuries - complications Peripheral Nerve Injuries - enzymology Psychoneuroimmunology Quinolinic acid RNA, Messenger - metabolism Signal Transduction Up-Regulation
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