Esophageal adenosquamous carcinoma mimicking acantholytic squamous cell carcinoma
Herein is described a unique case of esophageal cancer mimicking acantholytic squamous cell carcinoma (SCC). The patient succumbed to the disease within one month of diagnosis. Autopsy revealed a 10-cm esophageal tumor, characterized by prominent acantholysis-like areas composed of discohesive cance...
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| Veröffentlicht in: | Oncology letters 2017-10, Vol.14 (4), p.4918-4922 |
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| creator | Matsukuma, Susumu Takahashi, Oh Utsumi, Yoshitaka Tsuda, Masaki Miyai, Kosuke Okada, Kenji Takeo, Hiroaki |
| description | Herein is described a unique case of esophageal cancer mimicking acantholytic squamous cell carcinoma (SCC). The patient succumbed to the disease within one month of diagnosis. Autopsy revealed a 10-cm esophageal tumor, characterized by prominent acantholysis-like areas composed of discohesive cancer cells, along with nested growth of SCC. These discohesive cancer cells focally exhibited pagetoid extension into adjacent esophageal epithelium, comprised ~60% of the esophageal tumor volume and had widely metastasized to the lungs, chest wall, liver, spleen, right adrenal gland, bones and lymph nodes. No metastases of SCC were observed. SCC cells were immunohistochemically positive for keratin 5/6 and E-cadherin and were negative for mucin and carcinoembryonic antigen (CEA). However, the discohesive cancer cells exhibited negativity for keratin 5/6, positivity for mucin and CEA, and diminished or no immunostaining for E-cadherin. Thus, these discohesive cells represented true adenocarcinomatous differentiation rather than acantholytic SCC cells. It was concluded that this tumor was an esophageal adenosquamous carcinoma with 'pseudo'-acantholytic adenocarcinoma components, which should be considered as a rare but distinctive type of aggressive cancer. |
| doi_str_mv | 10.3892/ol.2017.6804 |
| format | Article |
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The patient succumbed to the disease within one month of diagnosis. Autopsy revealed a 10-cm esophageal tumor, characterized by prominent acantholysis-like areas composed of discohesive cancer cells, along with nested growth of SCC. These discohesive cancer cells focally exhibited pagetoid extension into adjacent esophageal epithelium, comprised ~60% of the esophageal tumor volume and had widely metastasized to the lungs, chest wall, liver, spleen, right adrenal gland, bones and lymph nodes. No metastases of SCC were observed. SCC cells were immunohistochemically positive for keratin 5/6 and E-cadherin and were negative for mucin and carcinoembryonic antigen (CEA). However, the discohesive cancer cells exhibited negativity for keratin 5/6, positivity for mucin and CEA, and diminished or no immunostaining for E-cadherin. Thus, these discohesive cells represented true adenocarcinomatous differentiation rather than acantholytic SCC cells. It was concluded that this tumor was an esophageal adenosquamous carcinoma with 'pseudo'-acantholytic adenocarcinoma components, which should be considered as a rare but distinctive type of aggressive cancer.</description><identifier>ISSN: 1792-1074</identifier><identifier>EISSN: 1792-1082</identifier><identifier>DOI: 10.3892/ol.2017.6804</identifier><identifier>PMID: 29085501</identifier><language>eng</language><publisher>Greece: Spandidos Publications UK Ltd</publisher><subject>Antigens ; Esophageal cancer ; Gangrene ; Lungs ; Lymphatic system ; Metastasis ; Oncology ; Self defense ; Squamous cell carcinoma</subject><ispartof>Oncology letters, 2017-10, Vol.14 (4), p.4918-4922</ispartof><rights>Copyright Spandidos Publications UK Ltd. 2017</rights><rights>Copyright © 2017, Spandidos Publications 2017</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c412t-b9034d073786c3ca16d503ca12cfe895da67871457b8ec22cd431de373cf640d3</citedby><cites>FETCH-LOGICAL-c412t-b9034d073786c3ca16d503ca12cfe895da67871457b8ec22cd431de373cf640d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5649535/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5649535/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29085501$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Matsukuma, Susumu</creatorcontrib><creatorcontrib>Takahashi, Oh</creatorcontrib><creatorcontrib>Utsumi, Yoshitaka</creatorcontrib><creatorcontrib>Tsuda, Masaki</creatorcontrib><creatorcontrib>Miyai, Kosuke</creatorcontrib><creatorcontrib>Okada, Kenji</creatorcontrib><creatorcontrib>Takeo, Hiroaki</creatorcontrib><title>Esophageal adenosquamous carcinoma mimicking acantholytic squamous cell carcinoma</title><title>Oncology letters</title><addtitle>Oncol Lett</addtitle><description>Herein is described a unique case of esophageal cancer mimicking acantholytic squamous cell carcinoma (SCC). The patient succumbed to the disease within one month of diagnosis. Autopsy revealed a 10-cm esophageal tumor, characterized by prominent acantholysis-like areas composed of discohesive cancer cells, along with nested growth of SCC. These discohesive cancer cells focally exhibited pagetoid extension into adjacent esophageal epithelium, comprised ~60% of the esophageal tumor volume and had widely metastasized to the lungs, chest wall, liver, spleen, right adrenal gland, bones and lymph nodes. No metastases of SCC were observed. SCC cells were immunohistochemically positive for keratin 5/6 and E-cadherin and were negative for mucin and carcinoembryonic antigen (CEA). However, the discohesive cancer cells exhibited negativity for keratin 5/6, positivity for mucin and CEA, and diminished or no immunostaining for E-cadherin. Thus, these discohesive cells represented true adenocarcinomatous differentiation rather than acantholytic SCC cells. It was concluded that this tumor was an esophageal adenosquamous carcinoma with 'pseudo'-acantholytic adenocarcinoma components, which should be considered as a rare but distinctive type of aggressive cancer.</description><subject>Antigens</subject><subject>Esophageal cancer</subject><subject>Gangrene</subject><subject>Lungs</subject><subject>Lymphatic system</subject><subject>Metastasis</subject><subject>Oncology</subject><subject>Self defense</subject><subject>Squamous cell carcinoma</subject><issn>1792-1074</issn><issn>1792-1082</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpd0c1LwzAYBvAgihtzN89S8OLBznw0XxdBxvyAgQh6DlmabZltszWtsP_elM1NzeUN5MdLHh4ALhEcESHxnS9GGCI-YgJmJ6CPuMQpggKfHu4864FhCCsYD2VICHYOelhCQSlEffA2CX691Auri0TntvJh0-rStyExujau8qVOSlc68-mqRaKNrpqlL7aNM8lR2qI48gtwNtdFsMP9HICPx8n7-Dmdvj69jB-mqckQbtKZhCTLISdcMEOMRiynsJvYzK2QNNeMC44yymfCGoxNnhGUW8KJmbMM5mQA7nd71-2stLmxVVPrQq1rV-p6q7x26u9L5ZZq4b8UZZmkhMYFN_sFtd-0NjSqdKHLoisbYykkqYgOMxLp9T-68m1dxXhRcYkwJARHdbtTpvYh1HZ--AyCqqtL-UJ1damursivfgc44J9yyDcNYJGI</recordid><startdate>20171001</startdate><enddate>20171001</enddate><creator>Matsukuma, Susumu</creator><creator>Takahashi, Oh</creator><creator>Utsumi, Yoshitaka</creator><creator>Tsuda, Masaki</creator><creator>Miyai, Kosuke</creator><creator>Okada, Kenji</creator><creator>Takeo, Hiroaki</creator><general>Spandidos Publications UK Ltd</general><general>D.A. Spandidos</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20171001</creationdate><title>Esophageal adenosquamous carcinoma mimicking acantholytic squamous cell carcinoma</title><author>Matsukuma, Susumu ; Takahashi, Oh ; Utsumi, Yoshitaka ; Tsuda, Masaki ; Miyai, Kosuke ; Okada, Kenji ; Takeo, Hiroaki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c412t-b9034d073786c3ca16d503ca12cfe895da67871457b8ec22cd431de373cf640d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Antigens</topic><topic>Esophageal cancer</topic><topic>Gangrene</topic><topic>Lungs</topic><topic>Lymphatic system</topic><topic>Metastasis</topic><topic>Oncology</topic><topic>Self defense</topic><topic>Squamous cell carcinoma</topic><toplevel>online_resources</toplevel><creatorcontrib>Matsukuma, Susumu</creatorcontrib><creatorcontrib>Takahashi, Oh</creatorcontrib><creatorcontrib>Utsumi, Yoshitaka</creatorcontrib><creatorcontrib>Tsuda, Masaki</creatorcontrib><creatorcontrib>Miyai, Kosuke</creatorcontrib><creatorcontrib>Okada, Kenji</creatorcontrib><creatorcontrib>Takeo, Hiroaki</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Oncology letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Matsukuma, Susumu</au><au>Takahashi, Oh</au><au>Utsumi, Yoshitaka</au><au>Tsuda, Masaki</au><au>Miyai, Kosuke</au><au>Okada, Kenji</au><au>Takeo, Hiroaki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Esophageal adenosquamous carcinoma mimicking acantholytic squamous cell carcinoma</atitle><jtitle>Oncology letters</jtitle><addtitle>Oncol Lett</addtitle><date>2017-10-01</date><risdate>2017</risdate><volume>14</volume><issue>4</issue><spage>4918</spage><epage>4922</epage><pages>4918-4922</pages><issn>1792-1074</issn><eissn>1792-1082</eissn><abstract>Herein is described a unique case of esophageal cancer mimicking acantholytic squamous cell carcinoma (SCC). The patient succumbed to the disease within one month of diagnosis. Autopsy revealed a 10-cm esophageal tumor, characterized by prominent acantholysis-like areas composed of discohesive cancer cells, along with nested growth of SCC. These discohesive cancer cells focally exhibited pagetoid extension into adjacent esophageal epithelium, comprised ~60% of the esophageal tumor volume and had widely metastasized to the lungs, chest wall, liver, spleen, right adrenal gland, bones and lymph nodes. No metastases of SCC were observed. SCC cells were immunohistochemically positive for keratin 5/6 and E-cadherin and were negative for mucin and carcinoembryonic antigen (CEA). However, the discohesive cancer cells exhibited negativity for keratin 5/6, positivity for mucin and CEA, and diminished or no immunostaining for E-cadherin. Thus, these discohesive cells represented true adenocarcinomatous differentiation rather than acantholytic SCC cells. It was concluded that this tumor was an esophageal adenosquamous carcinoma with 'pseudo'-acantholytic adenocarcinoma components, which should be considered as a rare but distinctive type of aggressive cancer.</abstract><cop>Greece</cop><pub>Spandidos Publications UK Ltd</pub><pmid>29085501</pmid><doi>10.3892/ol.2017.6804</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Antigens Esophageal cancer Gangrene Lungs Lymphatic system Metastasis Oncology Self defense Squamous cell carcinoma |
| title | Esophageal adenosquamous carcinoma mimicking acantholytic squamous cell carcinoma |
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