Deleterious Germline Mutations in Patients With Apparently Sporadic Pancreatic Adenocarcinoma

Purpose Deleterious germline mutations contribute to pancreatic cancer susceptibility and are well documented in families in which multiple members have had pancreatic cancer. Methods To define the prevalence of these germline mutations in patients with apparently sporadic pancreatic cancer, we sequ...

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Veröffentlicht in:	Journal of clinical oncology 2017-10, Vol.35 (30), p.3382-3390
Hauptverfasser:	Shindo, Koji, Yu, Jun, Suenaga, Masaya, Fesharakizadeh, Shahriar, Cho, Christy, Macgregor-Das, Anne, Siddiqui, Abdulrehman, Witmer, P Dane, Tamura, Koji, Song, Tae Jun, Navarro Almario, Jose Alejandro, Brant, Aaron, Borges, Michael, Ford, Madeline, Barkley, Thomas, He, Jin, Weiss, Matthew J, Wolfgang, Christopher L, Roberts, Nicholas J, Hruban, Ralph H, Klein, Alison P, Goggins, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Carcinoma, Pancreatic Ductal - epidemiology Carcinoma, Pancreatic Ductal - genetics Carcinoma, Pancreatic Ductal - therapy Female Gene Frequency Genetic Predisposition to Disease - genetics Germ-Line Mutation Humans Male Middle Aged Pancreatic Neoplasms - epidemiology Pancreatic Neoplasms - genetics Pancreatic Neoplasms - therapy Prevalence RAPID COMMUNICATION Sequence Analysis, DNA United States - epidemiology
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