Metabolic Instruction of Immunity
Choices have consequences. Immune cells survey and migrate throughout the body and sometimes take residence in niche environments with distinct communities of cells, extracellular matrix, and nutrients that may differ from those in which they matured. Imbedded in immune cell physiology are metabolic...
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| Veröffentlicht in: | Cell 2017-05, Vol.169 (4), p.570-586 |
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| container_title | Cell |
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| creator | Buck, Michael D. Sowell, Ryan T. Kaech, Susan M. Pearce, Erika L. |
| description | Choices have consequences. Immune cells survey and migrate throughout the body and sometimes take residence in niche environments with distinct communities of cells, extracellular matrix, and nutrients that may differ from those in which they matured. Imbedded in immune cell physiology are metabolic pathways and metabolites that not only provide energy and substrates for growth and survival, but also instruct effector functions, differentiation, and gene expression. This review of immunometabolism will reference the most recent literature to cover the choices that environments impose on the metabolism and function of immune cells and highlight their consequences during homeostasis and disease.
Immune cells are exposed to distinct environments and nutrients that influence metabolism that, in turn, instruct their effector functions, differentiation, and gene expression. |
| doi_str_mv | 10.1016/j.cell.2017.04.004 |
| format | Article |
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Immune cells are exposed to distinct environments and nutrients that influence metabolism that, in turn, instruct their effector functions, differentiation, and gene expression.</description><identifier>ISSN: 0092-8674</identifier><identifier>EISSN: 1097-4172</identifier><identifier>DOI: 10.1016/j.cell.2017.04.004</identifier><identifier>PMID: 28475890</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>aerobic glycolysis ; Animals ; barrier immunity ; checkpoint blockade ; Gastrointestinal Tract - cytology ; Gastrointestinal Tract - immunology ; Humans ; immunometabolism ; immunotherapy ; Leukocytes - cytology ; Leukocytes - immunology ; Leukocytes - metabolism ; metabolism ; mitochondria ; mitochondrial dynamics ; mucosa ; T-Lymphocytes - immunology ; Tumor Microenvironment</subject><ispartof>Cell, 2017-05, Vol.169 (4), p.570-586</ispartof><rights>2017 Elsevier Inc.</rights><rights>Copyright © 2017 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c504t-c0106e86d961d5e1abbcdb7aeae7b41d9179ffbc1ba2f3b70bff0bce38520faa3</citedby><cites>FETCH-LOGICAL-c504t-c0106e86d961d5e1abbcdb7aeae7b41d9179ffbc1ba2f3b70bff0bce38520faa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.cell.2017.04.004$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28475890$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Buck, Michael D.</creatorcontrib><creatorcontrib>Sowell, Ryan T.</creatorcontrib><creatorcontrib>Kaech, Susan M.</creatorcontrib><creatorcontrib>Pearce, Erika L.</creatorcontrib><title>Metabolic Instruction of Immunity</title><title>Cell</title><addtitle>Cell</addtitle><description>Choices have consequences. Immune cells survey and migrate throughout the body and sometimes take residence in niche environments with distinct communities of cells, extracellular matrix, and nutrients that may differ from those in which they matured. Imbedded in immune cell physiology are metabolic pathways and metabolites that not only provide energy and substrates for growth and survival, but also instruct effector functions, differentiation, and gene expression. This review of immunometabolism will reference the most recent literature to cover the choices that environments impose on the metabolism and function of immune cells and highlight their consequences during homeostasis and disease.
Immune cells are exposed to distinct environments and nutrients that influence metabolism that, in turn, instruct their effector functions, differentiation, and gene expression.</description><subject>aerobic glycolysis</subject><subject>Animals</subject><subject>barrier immunity</subject><subject>checkpoint blockade</subject><subject>Gastrointestinal Tract - cytology</subject><subject>Gastrointestinal Tract - immunology</subject><subject>Humans</subject><subject>immunometabolism</subject><subject>immunotherapy</subject><subject>Leukocytes - cytology</subject><subject>Leukocytes - immunology</subject><subject>Leukocytes - metabolism</subject><subject>metabolism</subject><subject>mitochondria</subject><subject>mitochondrial dynamics</subject><subject>mucosa</subject><subject>T-Lymphocytes - immunology</subject><subject>Tumor Microenvironment</subject><issn>0092-8674</issn><issn>1097-4172</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LxDAQhoMouq7-AQ-y3ry0TrJp04IIIn4srHjRc0jSiWZpG03aBf-9LbuKXjzNYZ73neEh5IRCSoHmF6vUYF2nDKhIgacAfIdMKJQi4VSwXTIBKFlS5IIfkMMYVwBQZFm2Tw5YwUVWlDAhZ4_YKe1rZ2aLNnahN53z7czb2aJp-tZ1n0dkz6o64vF2TsnL3e3zzUOyfLpf3FwvE5MB7xIDFHIs8qrMaZUhVVqbSguFCoXmtCqpKK3VhmrF7FwL0NaCNjgvMgZWqfmUXG1633vdYGWw7YKq5XtwjQqf0isn_25a9yZf_VpmOS-A0aHgfFsQ_EePsZONi6Mh1aLvo6RFmcO8FIwPKNugJvgYA9qfMxTk6Fau5JiUo1sJXA5uh9Dp7wd_It8yB-ByA-Cgae0wyGgctgYrF9B0svLuv_4vLouMUQ</recordid><startdate>20170504</startdate><enddate>20170504</enddate><creator>Buck, Michael D.</creator><creator>Sowell, Ryan T.</creator><creator>Kaech, Susan M.</creator><creator>Pearce, Erika L.</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170504</creationdate><title>Metabolic Instruction of Immunity</title><author>Buck, Michael D. ; Sowell, Ryan T. ; Kaech, Susan M. ; Pearce, Erika L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c504t-c0106e86d961d5e1abbcdb7aeae7b41d9179ffbc1ba2f3b70bff0bce38520faa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>aerobic glycolysis</topic><topic>Animals</topic><topic>barrier immunity</topic><topic>checkpoint blockade</topic><topic>Gastrointestinal Tract - cytology</topic><topic>Gastrointestinal Tract - immunology</topic><topic>Humans</topic><topic>immunometabolism</topic><topic>immunotherapy</topic><topic>Leukocytes - cytology</topic><topic>Leukocytes - immunology</topic><topic>Leukocytes - metabolism</topic><topic>metabolism</topic><topic>mitochondria</topic><topic>mitochondrial dynamics</topic><topic>mucosa</topic><topic>T-Lymphocytes - immunology</topic><topic>Tumor Microenvironment</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Buck, Michael D.</creatorcontrib><creatorcontrib>Sowell, Ryan T.</creatorcontrib><creatorcontrib>Kaech, Susan M.</creatorcontrib><creatorcontrib>Pearce, Erika L.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cell</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Buck, Michael D.</au><au>Sowell, Ryan T.</au><au>Kaech, Susan M.</au><au>Pearce, Erika L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Metabolic Instruction of Immunity</atitle><jtitle>Cell</jtitle><addtitle>Cell</addtitle><date>2017-05-04</date><risdate>2017</risdate><volume>169</volume><issue>4</issue><spage>570</spage><epage>586</epage><pages>570-586</pages><issn>0092-8674</issn><eissn>1097-4172</eissn><abstract>Choices have consequences. Immune cells survey and migrate throughout the body and sometimes take residence in niche environments with distinct communities of cells, extracellular matrix, and nutrients that may differ from those in which they matured. Imbedded in immune cell physiology are metabolic pathways and metabolites that not only provide energy and substrates for growth and survival, but also instruct effector functions, differentiation, and gene expression. This review of immunometabolism will reference the most recent literature to cover the choices that environments impose on the metabolism and function of immune cells and highlight their consequences during homeostasis and disease.
Immune cells are exposed to distinct environments and nutrients that influence metabolism that, in turn, instruct their effector functions, differentiation, and gene expression.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>28475890</pmid><doi>10.1016/j.cell.2017.04.004</doi><tpages>17</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete; Cell Press Free Archives; EZB-FREE-00999 freely available EZB journals |
| subjects | aerobic glycolysis Animals barrier immunity checkpoint blockade Gastrointestinal Tract - cytology Gastrointestinal Tract - immunology Humans immunometabolism immunotherapy Leukocytes - cytology Leukocytes - immunology Leukocytes - metabolism metabolism mitochondria mitochondrial dynamics mucosa T-Lymphocytes - immunology Tumor Microenvironment |
| title | Metabolic Instruction of Immunity |
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