Role of Periapical Diseases in Medication-Related Osteonecrosis of the Jaws
Objective. The present study aimed to investigate the role of periapical diseases in inducing medication-related osteonecrosis of the jaws (MRONJ) using an ovariectomized (OVX) mice model. Materials and Methods. Twenty C57BL/6N female mice were randomly assigned to two groups. All mice were subjecte...
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| description | Objective. The present study aimed to investigate the role of periapical diseases in inducing medication-related osteonecrosis of the jaws (MRONJ) using an ovariectomized (OVX) mice model. Materials and Methods. Twenty C57BL/6N female mice were randomly assigned to two groups. All mice were subjected to bilateral ovariectomy and then treated with oncologic dose of zoledronic acid (ZA) or vehicle for twelve weeks. Eight weeks after commence of drug administration, a pulpal exposure (PE) operation was performed on the first right lower molar to induce periapical periodontitis; the contralateral non-PE tooth was used as control. All animals were sacrificed four weeks after pulpal exposure, and the mandibles were harvested for radiological and histomorphometrical analysis. Results. Micro computed tomography (μ-CT) examination demonstrated that periapical diseases significantly increased alveolar bone resorption, and the resorption was greatly attenuated by ZA treatment. Concurrent ZA therapy significantly increased bone density and histological osteocyte necrosis in the presence of periapical lesions. Conclusion. ZA treatment reduced bone absorption resulting from periapical disease but increased the risk of developing MRONJ in the ovariectomized mouse model. |
| doi_str_mv | 10.1155/2017/1560175 |
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The present study aimed to investigate the role of periapical diseases in inducing medication-related osteonecrosis of the jaws (MRONJ) using an ovariectomized (OVX) mice model. Materials and Methods. Twenty C57BL/6N female mice were randomly assigned to two groups. All mice were subjected to bilateral ovariectomy and then treated with oncologic dose of zoledronic acid (ZA) or vehicle for twelve weeks. Eight weeks after commence of drug administration, a pulpal exposure (PE) operation was performed on the first right lower molar to induce periapical periodontitis; the contralateral non-PE tooth was used as control. All animals were sacrificed four weeks after pulpal exposure, and the mandibles were harvested for radiological and histomorphometrical analysis. Results. Micro computed tomography (μ-CT) examination demonstrated that periapical diseases significantly increased alveolar bone resorption, and the resorption was greatly attenuated by ZA treatment. Concurrent ZA therapy significantly increased bone density and histological osteocyte necrosis in the presence of periapical lesions. Conclusion. ZA treatment reduced bone absorption resulting from periapical disease but increased the risk of developing MRONJ in the ovariectomized mouse model.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2017/1560175</identifier><identifier>PMID: 29109954</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Alveolar bone ; Alveolar Bone Loss - drug therapy ; Alveolar Bone Loss - physiopathology ; Animals ; Biocompatibility ; Bone density ; Bone Density - drug effects ; Bone Density Conservation Agents - administration & dosage ; Bone resorption ; Bones ; Complications and side effects ; Computed tomography ; Dental caries ; Diphosphonates - administration & dosage ; Disease ; Disease Models, Animal ; Disease prevention ; Diseases ; Drugs ; Exposure ; Health risks ; Humans ; Imidazoles - administration & dosage ; Jaw - drug effects ; Jaw - physiopathology ; Jaw diseases ; Laboratory animals ; Lesions ; Mandible ; Mandible - drug effects ; Mandible - physiopathology ; Maxillofacial surgery ; Medical treatment ; Mice ; Molar - drug effects ; Molar - physiopathology ; Molar - surgery ; Necrosis ; Necrosis - physiopathology ; Osteocytes - drug effects ; Osteonecrosis ; Osteonecrosis - chemically induced ; Osteonecrosis - drug therapy ; Osteonecrosis - physiopathology ; Ovariectomy ; Pathogenesis ; Periapical Diseases - drug therapy ; Periapical Diseases - physiopathology ; Periodontal disease ; Periodontitis ; Risk factors ; Surgery ; Task forces ; Teeth ; Tomography ; Tomography, X-Ray Computed ; Zoledronic Acid</subject><ispartof>BioMed research international, 2017-01, Vol.2017 (2017), p.1-8</ispartof><rights>Copyright © 2017 Nian Jing Rao et al.</rights><rights>COPYRIGHT 2017 John Wiley & Sons, Inc.</rights><rights>Copyright © 2017 Nian Jing Rao et al.; This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2017 Nian Jing Rao et al. 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c525t-e9f1d3cc6497a08b03a4cb5ec70b06c1d28f72538868f16ace206583b7768c333</citedby><cites>FETCH-LOGICAL-c525t-e9f1d3cc6497a08b03a4cb5ec70b06c1d28f72538868f16ace206583b7768c333</cites><orcidid>0000-0002-6959-5589 ; 0000-0002-1654-5326 ; 0000-0002-7593-0208</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5646299/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5646299/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29109954$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Stoddart, Martin</contributor><creatorcontrib>Leung, Yiu Yan</creatorcontrib><creatorcontrib>Yu, Ru Qing</creatorcontrib><creatorcontrib>Wang, Jing Yi</creatorcontrib><creatorcontrib>Rao, Nian Jing</creatorcontrib><creatorcontrib>Zheng, Li Wu</creatorcontrib><title>Role of Periapical Diseases in Medication-Related Osteonecrosis of the Jaws</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>Objective. The present study aimed to investigate the role of periapical diseases in inducing medication-related osteonecrosis of the jaws (MRONJ) using an ovariectomized (OVX) mice model. Materials and Methods. Twenty C57BL/6N female mice were randomly assigned to two groups. All mice were subjected to bilateral ovariectomy and then treated with oncologic dose of zoledronic acid (ZA) or vehicle for twelve weeks. Eight weeks after commence of drug administration, a pulpal exposure (PE) operation was performed on the first right lower molar to induce periapical periodontitis; the contralateral non-PE tooth was used as control. All animals were sacrificed four weeks after pulpal exposure, and the mandibles were harvested for radiological and histomorphometrical analysis. Results. Micro computed tomography (μ-CT) examination demonstrated that periapical diseases significantly increased alveolar bone resorption, and the resorption was greatly attenuated by ZA treatment. Concurrent ZA therapy significantly increased bone density and histological osteocyte necrosis in the presence of periapical lesions. Conclusion. ZA treatment reduced bone absorption resulting from periapical disease but increased the risk of developing MRONJ in the ovariectomized mouse model.</description><subject>Alveolar bone</subject><subject>Alveolar Bone Loss - drug therapy</subject><subject>Alveolar Bone Loss - physiopathology</subject><subject>Animals</subject><subject>Biocompatibility</subject><subject>Bone density</subject><subject>Bone Density - drug effects</subject><subject>Bone Density Conservation Agents - administration & dosage</subject><subject>Bone resorption</subject><subject>Bones</subject><subject>Complications and side effects</subject><subject>Computed tomography</subject><subject>Dental caries</subject><subject>Diphosphonates - administration & dosage</subject><subject>Disease</subject><subject>Disease Models, Animal</subject><subject>Disease prevention</subject><subject>Diseases</subject><subject>Drugs</subject><subject>Exposure</subject><subject>Health risks</subject><subject>Humans</subject><subject>Imidazoles - 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drug therapy</topic><topic>Alveolar Bone Loss - physiopathology</topic><topic>Animals</topic><topic>Biocompatibility</topic><topic>Bone density</topic><topic>Bone Density - drug effects</topic><topic>Bone Density Conservation Agents - administration & dosage</topic><topic>Bone resorption</topic><topic>Bones</topic><topic>Complications and side effects</topic><topic>Computed tomography</topic><topic>Dental caries</topic><topic>Diphosphonates - administration & dosage</topic><topic>Disease</topic><topic>Disease Models, Animal</topic><topic>Disease prevention</topic><topic>Diseases</topic><topic>Drugs</topic><topic>Exposure</topic><topic>Health risks</topic><topic>Humans</topic><topic>Imidazoles - administration & dosage</topic><topic>Jaw - drug effects</topic><topic>Jaw - physiopathology</topic><topic>Jaw diseases</topic><topic>Laboratory animals</topic><topic>Lesions</topic><topic>Mandible</topic><topic>Mandible - drug effects</topic><topic>Mandible - physiopathology</topic><topic>Maxillofacial surgery</topic><topic>Medical treatment</topic><topic>Mice</topic><topic>Molar - drug effects</topic><topic>Molar - physiopathology</topic><topic>Molar - surgery</topic><topic>Necrosis</topic><topic>Necrosis - physiopathology</topic><topic>Osteocytes - drug effects</topic><topic>Osteonecrosis</topic><topic>Osteonecrosis - chemically induced</topic><topic>Osteonecrosis - drug therapy</topic><topic>Osteonecrosis - physiopathology</topic><topic>Ovariectomy</topic><topic>Pathogenesis</topic><topic>Periapical Diseases - drug therapy</topic><topic>Periapical Diseases - physiopathology</topic><topic>Periodontal disease</topic><topic>Periodontitis</topic><topic>Risk factors</topic><topic>Surgery</topic><topic>Task forces</topic><topic>Teeth</topic><topic>Tomography</topic><topic>Tomography, X-Ray Computed</topic><topic>Zoledronic Acid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Leung, Yiu Yan</creatorcontrib><creatorcontrib>Yu, Ru Qing</creatorcontrib><creatorcontrib>Wang, Jing Yi</creatorcontrib><creatorcontrib>Rao, Nian Jing</creatorcontrib><creatorcontrib>Zheng, Li Wu</creatorcontrib><collection>الدوريات العلمية والإحصائية - 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The present study aimed to investigate the role of periapical diseases in inducing medication-related osteonecrosis of the jaws (MRONJ) using an ovariectomized (OVX) mice model. Materials and Methods. Twenty C57BL/6N female mice were randomly assigned to two groups. All mice were subjected to bilateral ovariectomy and then treated with oncologic dose of zoledronic acid (ZA) or vehicle for twelve weeks. Eight weeks after commence of drug administration, a pulpal exposure (PE) operation was performed on the first right lower molar to induce periapical periodontitis; the contralateral non-PE tooth was used as control. All animals were sacrificed four weeks after pulpal exposure, and the mandibles were harvested for radiological and histomorphometrical analysis. Results. Micro computed tomography (μ-CT) examination demonstrated that periapical diseases significantly increased alveolar bone resorption, and the resorption was greatly attenuated by ZA treatment. Concurrent ZA therapy significantly increased bone density and histological osteocyte necrosis in the presence of periapical lesions. Conclusion. ZA treatment reduced bone absorption resulting from periapical disease but increased the risk of developing MRONJ in the ovariectomized mouse model.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>29109954</pmid><doi>10.1155/2017/1560175</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-6959-5589</orcidid><orcidid>https://orcid.org/0000-0002-1654-5326</orcidid><orcidid>https://orcid.org/0000-0002-7593-0208</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Alveolar bone Alveolar Bone Loss - drug therapy Alveolar Bone Loss - physiopathology Animals Biocompatibility Bone density Bone Density - drug effects Bone Density Conservation Agents - administration & dosage Bone resorption Bones Complications and side effects Computed tomography Dental caries Diphosphonates - administration & dosage Disease Disease Models, Animal Disease prevention Diseases Drugs Exposure Health risks Humans Imidazoles - administration & dosage Jaw - drug effects Jaw - physiopathology Jaw diseases Laboratory animals Lesions Mandible Mandible - drug effects Mandible - physiopathology Maxillofacial surgery Medical treatment Mice Molar - drug effects Molar - physiopathology Molar - surgery Necrosis Necrosis - physiopathology Osteocytes - drug effects Osteonecrosis Osteonecrosis - chemically induced Osteonecrosis - drug therapy Osteonecrosis - physiopathology Ovariectomy Pathogenesis Periapical Diseases - drug therapy Periapical Diseases - physiopathology Periodontal disease Periodontitis Risk factors Surgery Task forces Teeth Tomography Tomography, X-Ray Computed Zoledronic Acid |
| title | Role of Periapical Diseases in Medication-Related Osteonecrosis of the Jaws |
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