Stereocontrolled protein surface recognition using chiral oligoamide proteomimetic foldamers
The development of foldamers capable of selective molecular recognition of solvent exposed protein surfaces represents an outstanding challenge in supramolecular chemical biology. Here we introduce an oligoamide foldamer with well-defined conformation that bears all the hallmarks of an information r...
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| Veröffentlicht in: | Chemical science (Cambridge) 2015-04, Vol.6 (4), p.2434-2443 |
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| creator | Azzarito, Valeria Miles, Jennifer A Fisher, Julie Edwards, Thomas A Warriner, Stuart L Wilson, Andrew J |
| description | The development of foldamers capable of selective molecular recognition of solvent exposed protein surfaces represents an outstanding challenge in supramolecular chemical biology. Here we introduce an oligoamide foldamer with well-defined conformation that bears all the hallmarks of an information rich oligomer. Specifically, the foldamer recognizes its target protein
DM2 leading to inhibition of its protein-protein interaction with p53 in a manner that depends upon the composition, spatial projection and stereochemistry of functional groups appended to the scaffold. Most significantly, selective inhibition of p53/
DM2 can be achieved against four other targets and the selectivity for p53/
DM2 inhibition
Mcl-1/NOXA-B inhibition is critically dependent upon the stereochemistry of the helix mimetic. |
| doi_str_mv | 10.1039/c4sc03559c |
| format | Article |
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DM2 leading to inhibition of its protein-protein interaction with p53 in a manner that depends upon the composition, spatial projection and stereochemistry of functional groups appended to the scaffold. Most significantly, selective inhibition of p53/
DM2 can be achieved against four other targets and the selectivity for p53/
DM2 inhibition
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DM2 leading to inhibition of its protein-protein interaction with p53 in a manner that depends upon the composition, spatial projection and stereochemistry of functional groups appended to the scaffold. Most significantly, selective inhibition of p53/
DM2 can be achieved against four other targets and the selectivity for p53/
DM2 inhibition
Mcl-1/NOXA-B inhibition is critically dependent upon the stereochemistry of the helix mimetic.</description><subject>Biology</subject><subject>Chemistry</subject><subject>Inhibition</subject><subject>Projection</subject><subject>Proteins</subject><subject>Recognition</subject><subject>Solvents</subject><subject>Stereochemistry</subject><issn>2041-6520</issn><issn>2041-6539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNqFkUtLxTAQhYMoKlc3_gDpUoSrefWRjSDFFwgu1J0Q0sn0Gkmba9IK_nurVy-6MpsJzJmPOXMIOWD0hFGhTkEmoCLPFWyQXU4lmxe5UJvrP6c7ZD-lFzo9IVjOy22yw5WgFcvzXfJ0P2DEAKEfYvAebbaMYUDXZ2mMrQHMIkJY9G5woc_G5PpFBs8uGp8F7xbBdM7iaiZ0rsPBQdYGb02HMe2Rrdb4hPvfdUYeLy8e6uv57d3VTX1-OwfJ2DBvqLBMGtPYpuSGKltxAaLgTSUsWlG1BVDDmeKmtHzyCo2RFHgDbStQKhAzcrbiLsemQws4mTFeL6PrTHzXwTj9t9O7Z70IbzovZMELNgGOvgExvI6YBt25BOi96TGMSTNVqVyW05n_l5ZVwSpViE_q8UoKMaQUsV1vxKj-DE_X8r7-Cq-exIe_PaylP1GJD9YpmDU</recordid><startdate>20150401</startdate><enddate>20150401</enddate><creator>Azzarito, Valeria</creator><creator>Miles, Jennifer A</creator><creator>Fisher, Julie</creator><creator>Edwards, Thomas A</creator><creator>Warriner, Stuart L</creator><creator>Wilson, Andrew J</creator><general>Royal Society of Chemistry</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150401</creationdate><title>Stereocontrolled protein surface recognition using chiral oligoamide proteomimetic foldamers</title><author>Azzarito, Valeria ; Miles, Jennifer A ; Fisher, Julie ; Edwards, Thomas A ; Warriner, Stuart L ; Wilson, Andrew J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c411t-b03d14aabdb72a09d823c362b83ded38f6c0a2192a7d2035cba40c2bcff3e49c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Biology</topic><topic>Chemistry</topic><topic>Inhibition</topic><topic>Projection</topic><topic>Proteins</topic><topic>Recognition</topic><topic>Solvents</topic><topic>Stereochemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Azzarito, Valeria</creatorcontrib><creatorcontrib>Miles, Jennifer A</creatorcontrib><creatorcontrib>Fisher, Julie</creatorcontrib><creatorcontrib>Edwards, Thomas A</creatorcontrib><creatorcontrib>Warriner, Stuart L</creatorcontrib><creatorcontrib>Wilson, Andrew J</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Chemical science (Cambridge)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Azzarito, Valeria</au><au>Miles, Jennifer A</au><au>Fisher, Julie</au><au>Edwards, Thomas A</au><au>Warriner, Stuart L</au><au>Wilson, Andrew J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Stereocontrolled protein surface recognition using chiral oligoamide proteomimetic foldamers</atitle><jtitle>Chemical science (Cambridge)</jtitle><addtitle>Chem Sci</addtitle><date>2015-04-01</date><risdate>2015</risdate><volume>6</volume><issue>4</issue><spage>2434</spage><epage>2443</epage><pages>2434-2443</pages><issn>2041-6520</issn><eissn>2041-6539</eissn><abstract>The development of foldamers capable of selective molecular recognition of solvent exposed protein surfaces represents an outstanding challenge in supramolecular chemical biology. Here we introduce an oligoamide foldamer with well-defined conformation that bears all the hallmarks of an information rich oligomer. Specifically, the foldamer recognizes its target protein
DM2 leading to inhibition of its protein-protein interaction with p53 in a manner that depends upon the composition, spatial projection and stereochemistry of functional groups appended to the scaffold. Most significantly, selective inhibition of p53/
DM2 can be achieved against four other targets and the selectivity for p53/
DM2 inhibition
Mcl-1/NOXA-B inhibition is critically dependent upon the stereochemistry of the helix mimetic.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>29308155</pmid><doi>10.1039/c4sc03559c</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Chemical science (Cambridge), 2015-04, Vol.6 (4), p.2434-2443 |
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| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | Biology Chemistry Inhibition Projection Proteins Recognition Solvents Stereochemistry |
| title | Stereocontrolled protein surface recognition using chiral oligoamide proteomimetic foldamers |
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