In vivo targeting of metastatic breast cancer via tumor vasculature-specific nano-graphene oxide

Abstract Angiogenesis, i.e. the formation of neovasculatures, is a critical process during cancer initiation, progression, and metastasis. Targeting of angiogenic markers on the tumor vasculature can result in more efficient delivery of nanomaterials into tumor since no extravasation is required. He...

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Veröffentlicht in:	Biomaterials 2016-10, Vol.104, p.361-371
Hauptverfasser:	Yang, Dongzhi, Feng, Liangzhu, Dougherty, Casey A, Luker, Kathryn E, Chen, Daiqin, Cauble, Meagan A, Banaszak Holl, Mark M, Luker, Gary D, Ross, Brian D, Liu, Zhuang, Hong, Hao
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science Angiogenesis Angiogenesis Inhibitors - administration & dosage animal models Animals Antibodies, Monoclonal - administration & dosage atomic force microscopy bioluminescence Breast cancer metastasis breast neoplasms Breast Neoplasms - blood supply Breast Neoplasms - pathology Breast Neoplasms - therapy Cell Line, Tumor Dentistry doxorubicin Doxorubicin - administration & dosage drug carriers Drug Delivery Systems - methods Female females flow cytometry fluorescence fluorescence microscopy Follicle-stimulating hormone receptor (FSHR) follicle-stimulating hormone receptors Graphite - chemistry histology Humans image analysis Image-guided drug delivery in vivo studies intravenous injection liver lung neoplasms Lung Neoplasms - blood supply Lung Neoplasms - secondary Lung Neoplasms - therapy metastasis Mice Mice, Nude Molecular Targeted Therapy - methods monoclonal antibodies Nano-graphene oxide (GO) Nanocapsules - administration & dosage Nanocapsules - chemistry Nanoconjugates - chemistry nanomaterials neoplasm cells Neovascularization, Pathologic - pathology Neovascularization, Pathologic - therapy Oxides - chemistry Positron emission tomography (PET) positron-emission tomography spleen tissue distribution transmission electron microscopy Treatment Outcome
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