Substance P induces plasticity and synaptic tagging/capture in rat hippocampal area CA2

The hippocampal area Cornu Ammonis (CA) CA2 is important for social interaction and is innervated by Substance P (SP)-expressing supramammillary (SuM) nucleus neurons. SP exerts neuromodulatory effects on pain processing and central synaptic transmission. Here we provide evidence that SP can induce...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2017-10, Vol.114 (41), p.E8741-E8749
Hauptverfasser:	Dasgupta, Ananya, Baby, Nimmi, Krishna, Kumar, Hakim, Muhammad, Wong, Yuk Peng, Behnisch, Thomas, Soong, Tuck Wah, Sajikumar, Sreedharan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Sciences CA2 Region, Hippocampal - drug effects CA2 Region, Hippocampal - physiology Ca2+/calmodulin-dependent protein kinase IV Cells, Cultured Cortex Electric Stimulation Glutamic acid receptors (ionotropic) Hippocampal plasticity Hippocampus Long-Term Potentiation Marking N-Methyl-D-aspartic acid receptors Neuromodulation Neuronal Plasticity - drug effects Neuronal Plasticity - physiology Neurons Neurons - cytology Neurons - drug effects Neurons - metabolism Pain Plastic properties Plasticity PNAS Plus Protein biosynthesis Protein synthesis Rats Short-term potentiation Social interaction Substance P Substance P - pharmacology Synapses Synapses - drug effects Synapses - physiology Synaptic plasticity Synaptic transmission Synaptic Transmission - drug effects Synaptic Transmission - physiology Synaptogenesis γ-Aminobutyric acid
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