Systems biology analysis of longitudinal functional response of endothelial cells to shear stress

Blood flow and vascular shear stress patterns play a significant role in inducing and modulating physiological responses of endothelial cells (ECs). Pulsatile shear (PS) is associated with an atheroprotective endothelial phenotype, while oscillatory shear (OS) is associated with an atheroprone endot...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2017-10, Vol.114 (41), p.10990-10995
Hauptverfasser:	Ajami, Nassim E., Gupta, Shakti, Maurya, Mano R., Nguyen, Phu, Li, Julie Yi-Shuan, Shyy, John Y.-J., Chen, Zhen, Chien, Shu, Subramaniam, Shankar
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Sciences Blood flow Cell Cycle Cells, Cultured Data processing Endothelial cells Endothelium, Vascular - metabolism Epithelial-Mesenchymal Transition Gene expression Gene Expression Regulation Gene regulation Human Umbilical Vein Endothelial Cells - metabolism Humans Inflammation Mechanical stimuli Oxidative Stress Pathogenesis Pathology Physiological responses Pulsatile Flow Shear stress Stress, Mechanical Systems analysis Systems Biology - methods Time series Transcription factors Transcription Factors - genetics Transcriptome Vascular diseases
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