Insulin-like growth factor 1 signaling is essential for mitochondrial biogenesis and mitophagy in cancer cells

Mitochondrial activity and metabolic reprogramming influence the phenotype of cancer cells and resistance to targeted therapy. We previously established that an insulin-like growth factor 1 (IGF-1)-inducible mitochondrial UTP carrier (PNC1/SLC25A33) promotes cell growth. This prompted us to investig...

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Veröffentlicht in:	The Journal of biological chemistry 2017-10, Vol.292 (41), p.16983-16998
Hauptverfasser:	Lyons, Amy, Coleman, Michael, Riis, Sarah, Favre, Cedric, O'Flanagan, Ciara H., Zhdanov, Alexander V., Papkovsky, Dmitri B., Hursting, Stephen D., O'Connor, Rosemary
Format:	Artikel
Sprache:	eng
Schlagworte:	cancer biology cancer therapy Carrier Proteins - genetics Carrier Proteins - metabolism cell metabolism cell signaling cell surface receptor Cell Survival - genetics drug resistance Humans insulin-like growth factor (IGF) Insulin-Like Growth Factor I - genetics Insulin-Like Growth Factor I - metabolism MCF-7 Cells Membrane Proteins - genetics Membrane Proteins - metabolism mitochondria Mitochondria - genetics Mitochondria - metabolism Mitochondrial Dynamics Mitophagy Molecular Bases of Disease Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology NF-E2-Related Factor 2 - genetics NF-E2-Related Factor 2 - metabolism Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - genetics Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - metabolism Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Receptor, IGF Type 1 Receptors, Somatomedin - genetics Receptors, Somatomedin - metabolism RNA-Binding Proteins Signal Transduction Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism
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