PrP P102L and Nearby Lysine Mutations Promote Spontaneous In Vitro Formation of Transmissible Prions

Accumulation of fibrillar protein aggregates is a hallmark of many diseases. While numerous proteins form fibrils by prion-like seeded polymerization , only some are transmissible and pathogenic To probe the structural features that confer transmissibility to prion protein (PrP) fibrils, we have ana...

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