A new look at the role of thiolate ligation in cytochrome P450

Protonated ferryl (or iron(IV)hydroxide) intermediates have been characterized in several thiolate-ligated heme proteins that are known to catalyze C–H bond activation. The basicity of the ferryl intermediates in these species has been proposed to play a critical role in facilitating this chemistry,...

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Veröffentlicht in:	Journal of biological inorganic chemistry 2017-04, Vol.22 (2-3), p.209-220
Hauptverfasser:	Yosca, Timothy H., Ledray, Aaron P., Ngo, Joanna, Green, Michael T.
Format:	Artikel
Sprache:	eng
Schlagworte:	60 Years of Oxygen Activation Biochemistry Biomedical and Life Sciences Commentary Cytochrome P-450 Enzyme System - chemistry Cytochrome P-450 Enzyme System - metabolism Cytochrome P450 Ferric Compounds - chemistry Ferric Compounds - metabolism Heme proteins Inorganic chemistry Intermediates Iron Life Sciences Microbiology Sulfhydryl Compounds - chemistry Sulfhydryl Compounds - metabolism
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