Chronic morphine reduces the readily releasable pool of GABA, a presynaptic mechanism of opioid tolerance

Key points Chronic treatment with opioids, such as morphine, leads to analgesic tolerance. While postsynaptic opioid tolerance is well documented, the involvement of presynaptic mechanisms remains unclear. We show that chronic morphine reduces the ability of periaqueductal grey (PAG) neurons to main...

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