Development of vaccines against Crimean-Congo haemorrhagic fever virus
Crimean-Congo haemorrhagic fever virus (CCHFV) is a deadly human pathogen of the utmost seriousness being highly lethal causing devastating disease symptoms that result in intense and prolonged suffering to those infected. During the past 40years, this virus has repeatedly caused sporadic outbreaks...
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description | Crimean-Congo haemorrhagic fever virus (CCHFV) is a deadly human pathogen of the utmost seriousness being highly lethal causing devastating disease symptoms that result in intense and prolonged suffering to those infected. During the past 40years, this virus has repeatedly caused sporadic outbreaks responsible for relatively low numbers of human casualties, but with an alarming fatality rate of up to 80% in clinically infected patients. CCHFV is transmitted to humans by Hyalomma ticks and contact with the blood of viremic livestock, additionally cases of human-to-human transmission are not uncommon in nosocomial settings. The incidence of CCHF closely matches the geographical range of permissive ticks, which are widespread throughout Africa, Asia, the Middle East and Europe. As such, CCHFV is the most widespread tick-borne virus on earth. It is a concern that recent data shows the geographic distribution of Hyalomma ticks is expanding. Migratory birds are also disseminating Hyalomma ticks into more northerly parts of Europe thus potentially exposing naïve human populations to CCHFV. The virus has been imported into the UK on two occasions in the last five years with the first fatal case being confirmed in 2012. A licensed vaccine to CCHF is not available. In this review, we discuss the background and complications surrounding this limitation and examine the current status and recent advances in the development of vaccines against CCHFV. |
doi_str_mv | 10.1016/j.vaccine.2017.05.031 |
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During the past 40years, this virus has repeatedly caused sporadic outbreaks responsible for relatively low numbers of human casualties, but with an alarming fatality rate of up to 80% in clinically infected patients. CCHFV is transmitted to humans by Hyalomma ticks and contact with the blood of viremic livestock, additionally cases of human-to-human transmission are not uncommon in nosocomial settings. The incidence of CCHF closely matches the geographical range of permissive ticks, which are widespread throughout Africa, Asia, the Middle East and Europe. As such, CCHFV is the most widespread tick-borne virus on earth. It is a concern that recent data shows the geographic distribution of Hyalomma ticks is expanding. Migratory birds are also disseminating Hyalomma ticks into more northerly parts of Europe thus potentially exposing naïve human populations to CCHFV. The virus has been imported into the UK on two occasions in the last five years with the first fatal case being confirmed in 2012. A licensed vaccine to CCHF is not available. In this review, we discuss the background and complications surrounding this limitation and examine the current status and recent advances in the development of vaccines against CCHFV.</description><identifier>ISSN: 0264-410X</identifier><identifier>EISSN: 1873-2518</identifier><identifier>DOI: 10.1016/j.vaccine.2017.05.031</identifier><identifier>PMID: 28687403</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Africa ; animal pathogens ; Animals ; Arachnids ; Asia ; Birds ; blood ; Casualties ; Crimean hemorrhagic fever ; Crimean-Congo haemorrhagic fever ; Crimean-Congo hemorrhagic fever orthonairovirus ; cross infection ; Cross Infection - immunology ; Cross Infection - prevention & control ; Disease ; Disease transmission ; Ebola virus ; Ebolavirus ; Fever ; Geographical distribution ; Geography - methods ; Glycoproteins ; Hemorrhagic Fever Virus, Crimean-Congo - immunology ; Hemorrhagic Fever, Crimean - immunology ; Hemorrhagic Fever, Crimean - prevention & control ; Hospitals ; human population ; Human populations ; Humans ; Hyalomma ; Immunoglobulins ; Incidence ; Infections ; Ixodidae - immunology ; Livestock ; Middle East ; Migratory birds ; mortality ; Nosocomial infection ; Outbreaks ; Pathogenesis ; patients ; Review ; RNA polymerase ; Ticks ; United Kingdom ; Vaccine ; vaccine development ; Vaccines ; Vaccines - immunology ; Viral infections ; viruses ; Zoonoses</subject><ispartof>Vaccine, 2017-10, Vol.35 (44), p.6015-6023</ispartof><rights>2017</rights><rights>Crown Copyright © 2017. Published by Elsevier Ltd. All rights reserved.</rights><rights>Copyright Elsevier Limited Oct 20, 2017</rights><rights>Crown Copyright © 2017 Published by Elsevier Ltd. All rights reserved. 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c528t-e07b5ff85b073c7444d6e0dfca16aadeb2a20827defa374dd92aee572fc3a2c93</citedby><cites>FETCH-LOGICAL-c528t-e07b5ff85b073c7444d6e0dfca16aadeb2a20827defa374dd92aee572fc3a2c93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1949655250?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>230,314,778,782,883,3539,27907,27908,45978,64366,64368,64370,72220</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28687403$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dowall, Stuart D.</creatorcontrib><creatorcontrib>Carroll, Miles W.</creatorcontrib><creatorcontrib>Hewson, Roger</creatorcontrib><title>Development of vaccines against Crimean-Congo haemorrhagic fever virus</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>Crimean-Congo haemorrhagic fever virus (CCHFV) is a deadly human pathogen of the utmost seriousness being highly lethal causing devastating disease symptoms that result in intense and prolonged suffering to those infected. During the past 40years, this virus has repeatedly caused sporadic outbreaks responsible for relatively low numbers of human casualties, but with an alarming fatality rate of up to 80% in clinically infected patients. CCHFV is transmitted to humans by Hyalomma ticks and contact with the blood of viremic livestock, additionally cases of human-to-human transmission are not uncommon in nosocomial settings. The incidence of CCHF closely matches the geographical range of permissive ticks, which are widespread throughout Africa, Asia, the Middle East and Europe. As such, CCHFV is the most widespread tick-borne virus on earth. It is a concern that recent data shows the geographic distribution of Hyalomma ticks is expanding. Migratory birds are also disseminating Hyalomma ticks into more northerly parts of Europe thus potentially exposing naïve human populations to CCHFV. The virus has been imported into the UK on two occasions in the last five years with the first fatal case being confirmed in 2012. A licensed vaccine to CCHF is not available. In this review, we discuss the background and complications surrounding this limitation and examine the current status and recent advances in the development of vaccines against CCHFV.</description><subject>Africa</subject><subject>animal pathogens</subject><subject>Animals</subject><subject>Arachnids</subject><subject>Asia</subject><subject>Birds</subject><subject>blood</subject><subject>Casualties</subject><subject>Crimean hemorrhagic fever</subject><subject>Crimean-Congo haemorrhagic fever</subject><subject>Crimean-Congo hemorrhagic fever orthonairovirus</subject><subject>cross infection</subject><subject>Cross Infection - immunology</subject><subject>Cross Infection - prevention & control</subject><subject>Disease</subject><subject>Disease transmission</subject><subject>Ebola virus</subject><subject>Ebolavirus</subject><subject>Fever</subject><subject>Geographical distribution</subject><subject>Geography - methods</subject><subject>Glycoproteins</subject><subject>Hemorrhagic Fever Virus, Crimean-Congo - immunology</subject><subject>Hemorrhagic Fever, Crimean - immunology</subject><subject>Hemorrhagic Fever, Crimean - prevention & control</subject><subject>Hospitals</subject><subject>human population</subject><subject>Human populations</subject><subject>Humans</subject><subject>Hyalomma</subject><subject>Immunoglobulins</subject><subject>Incidence</subject><subject>Infections</subject><subject>Ixodidae - immunology</subject><subject>Livestock</subject><subject>Middle East</subject><subject>Migratory birds</subject><subject>mortality</subject><subject>Nosocomial infection</subject><subject>Outbreaks</subject><subject>Pathogenesis</subject><subject>patients</subject><subject>Review</subject><subject>RNA polymerase</subject><subject>Ticks</subject><subject>United Kingdom</subject><subject>Vaccine</subject><subject>vaccine development</subject><subject>Vaccines</subject><subject>Vaccines - immunology</subject><subject>Viral infections</subject><subject>viruses</subject><subject>Zoonoses</subject><issn>0264-410X</issn><issn>1873-2518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkU1v1DAYhC0EokvhJ4AiceGS9PVXnFxA1UKhUiUurcTN8jqvd71K4sVOIvHv8WqXCrj05IOfGY9nCHlLoaJA66t9tRhr_YgVA6oqkBVw-oysaKN4ySRtnpMVsFqUgsKPC_IqpT0ASE7bl-SCNXWjBPAVufmMC_bhMOA4FcEVZ9NUmK3xY5qKdfQDmrFch3Ebip3BIcS4M1tvC5elsVh8nNNr8sKZPuGb83lJHm6-3K-_lXffv96ur-9KK1kzlQhqI51r5AYUt0oI0dUInbOG1sZ0uGGGQcNUh85wJbquZQZRKuYsN8y2_JJ8PPke5s2Anc2po-n1IYc08ZcOxut_b0a_09uwaFlzpeBo8OFsEMPPGdOkB58s9r0ZMcxJs1wSl20t2JMobaniNW8Zzej7_9B9mOOYm8iUaGspmYRMyRNlY0gponvMTUEfR9V7fe5fH0fVIHUeNeve_f3pR9WfFTPw6QRgrn7xGHWyHkeLnY9oJ90F_8QTvwGD2rbu</recordid><startdate>20171020</startdate><enddate>20171020</enddate><creator>Dowall, Stuart D.</creator><creator>Carroll, Miles W.</creator><creator>Hewson, Roger</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><general>Elsevier Science</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7T2</scope><scope>7T5</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope></search><sort><creationdate>20171020</creationdate><title>Development of vaccines against Crimean-Congo haemorrhagic fever virus</title><author>Dowall, Stuart D. ; Carroll, Miles W. ; Hewson, Roger</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c528t-e07b5ff85b073c7444d6e0dfca16aadeb2a20827defa374dd92aee572fc3a2c93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Africa</topic><topic>animal pathogens</topic><topic>Animals</topic><topic>Arachnids</topic><topic>Asia</topic><topic>Birds</topic><topic>blood</topic><topic>Casualties</topic><topic>Crimean hemorrhagic fever</topic><topic>Crimean-Congo haemorrhagic fever</topic><topic>Crimean-Congo hemorrhagic fever orthonairovirus</topic><topic>cross infection</topic><topic>Cross Infection - 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Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Vaccine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dowall, Stuart D.</au><au>Carroll, Miles W.</au><au>Hewson, Roger</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Development of vaccines against Crimean-Congo haemorrhagic fever virus</atitle><jtitle>Vaccine</jtitle><addtitle>Vaccine</addtitle><date>2017-10-20</date><risdate>2017</risdate><volume>35</volume><issue>44</issue><spage>6015</spage><epage>6023</epage><pages>6015-6023</pages><issn>0264-410X</issn><eissn>1873-2518</eissn><abstract>Crimean-Congo haemorrhagic fever virus (CCHFV) is a deadly human pathogen of the utmost seriousness being highly lethal causing devastating disease symptoms that result in intense and prolonged suffering to those infected. During the past 40years, this virus has repeatedly caused sporadic outbreaks responsible for relatively low numbers of human casualties, but with an alarming fatality rate of up to 80% in clinically infected patients. CCHFV is transmitted to humans by Hyalomma ticks and contact with the blood of viremic livestock, additionally cases of human-to-human transmission are not uncommon in nosocomial settings. The incidence of CCHF closely matches the geographical range of permissive ticks, which are widespread throughout Africa, Asia, the Middle East and Europe. As such, CCHFV is the most widespread tick-borne virus on earth. It is a concern that recent data shows the geographic distribution of Hyalomma ticks is expanding. Migratory birds are also disseminating Hyalomma ticks into more northerly parts of Europe thus potentially exposing naïve human populations to CCHFV. The virus has been imported into the UK on two occasions in the last five years with the first fatal case being confirmed in 2012. A licensed vaccine to CCHF is not available. In this review, we discuss the background and complications surrounding this limitation and examine the current status and recent advances in the development of vaccines against CCHFV.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>28687403</pmid><doi>10.1016/j.vaccine.2017.05.031</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Africa animal pathogens Animals Arachnids Asia Birds blood Casualties Crimean hemorrhagic fever Crimean-Congo haemorrhagic fever Crimean-Congo hemorrhagic fever orthonairovirus cross infection Cross Infection - immunology Cross Infection - prevention & control Disease Disease transmission Ebola virus Ebolavirus Fever Geographical distribution Geography - methods Glycoproteins Hemorrhagic Fever Virus, Crimean-Congo - immunology Hemorrhagic Fever, Crimean - immunology Hemorrhagic Fever, Crimean - prevention & control Hospitals human population Human populations Humans Hyalomma Immunoglobulins Incidence Infections Ixodidae - immunology Livestock Middle East Migratory birds mortality Nosocomial infection Outbreaks Pathogenesis patients Review RNA polymerase Ticks United Kingdom Vaccine vaccine development Vaccines Vaccines - immunology Viral infections viruses Zoonoses |
title | Development of vaccines against Crimean-Congo haemorrhagic fever virus |
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