Modelling the impact of targeted anthelmintic treatment of cattle on dung fauna
•Assessment of the impact of anthelmintic targeted selected treatment on invertebrates.•Practical risk matrix to assess the impact of treatment programs.•Novel approach to life cycle modelling of invertebrates.•Targeted selective treatment mitigates ecological impact of anthelmintics via refugia. Th...
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| Veröffentlicht in: | Environmental toxicology and pharmacology 2017-10, Vol.55, p.94-98 |
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| creator | Cooke, Andrew S. Morgan, Eric R. Dungait, Jennifer A.J. |
| description | •Assessment of the impact of anthelmintic targeted selected treatment on invertebrates.•Practical risk matrix to assess the impact of treatment programs.•Novel approach to life cycle modelling of invertebrates.•Targeted selective treatment mitigates ecological impact of anthelmintics via refugia.
The insecticidal properties of many anthelmintics pose a risk to dung fauna through the effects of drug residues in dung on the activity, oviposition and development of dung-dwelling invertebrates. Reductions in dung fauna numbers can inhibit dung degradation, which may impact biodiversity and nutrient cycling on farms. A simulation model was created to predict the impact of antiparasitic drugs on cattle dung fauna, and calibrated using published data on the dung-breeding fly Scathophaga stercoraria. This model was then tested under different effective dung drug concentrations (EC) and proportions of treated cattle (PT) to determine the impact under different application regimens. EC accounted for 12.9% of the observed variation in S. stercoraria population size, whilst PT accounted for 54.9%. The model outputs indicate that the tendency within veterinary medicine for targeted selective treatments (TST), in order to attenuate selection for drug resistance in parasite populations, will decrease the negative impacts of treatments on dung fauna populations by providing population refugia. This provides novel evidence for the benefits of TST regimens on local food webs, relative to whole-herd treatments. The model outputs were used to create a risk graph for stakeholders to use to estimate risk of anthelminthic toxicity to dung fauna. |
| doi_str_mv | 10.1016/j.etap.2017.07.012 |
| format | Article |
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The insecticidal properties of many anthelmintics pose a risk to dung fauna through the effects of drug residues in dung on the activity, oviposition and development of dung-dwelling invertebrates. Reductions in dung fauna numbers can inhibit dung degradation, which may impact biodiversity and nutrient cycling on farms. A simulation model was created to predict the impact of antiparasitic drugs on cattle dung fauna, and calibrated using published data on the dung-breeding fly Scathophaga stercoraria. This model was then tested under different effective dung drug concentrations (EC) and proportions of treated cattle (PT) to determine the impact under different application regimens. EC accounted for 12.9% of the observed variation in S. stercoraria population size, whilst PT accounted for 54.9%. The model outputs indicate that the tendency within veterinary medicine for targeted selective treatments (TST), in order to attenuate selection for drug resistance in parasite populations, will decrease the negative impacts of treatments on dung fauna populations by providing population refugia. This provides novel evidence for the benefits of TST regimens on local food webs, relative to whole-herd treatments. The model outputs were used to create a risk graph for stakeholders to use to estimate risk of anthelminthic toxicity to dung fauna.</description><identifier>ISSN: 1382-6689</identifier><identifier>EISSN: 1872-7077</identifier><identifier>DOI: 10.1016/j.etap.2017.07.012</identifier><identifier>PMID: 28843101</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Agriculture ; Animals ; Anthelmintic agents ; Anthelmintic resistance ; Anthelmintics - adverse effects ; Antiparasitic ; Biodiversity ; Bovidae ; Cattle ; Cattle manure ; Computer simulation ; Data processing ; Diptera - drug effects ; Diptera - growth & development ; Drug resistance ; Dung ; Environment ; Environmental Monitoring ; Farms ; Fauna ; Feces - chemistry ; Food chains ; Food webs ; Helminth ; Insecticide resistance ; Insecticides - adverse effects ; Invertebrates ; Livestock breeding ; Model testing ; Models, Chemical ; Nutrient cycles ; Oviposition ; Parasites ; Pesticide Residues ; Population Density ; Population number ; Populations ; Refugia ; Risk ; Scathophaga stercoraria ; Targeted selective treatment ; Toxicity ; Veterinary medicine</subject><ispartof>Environmental toxicology and pharmacology, 2017-10, Vol.55, p.94-98</ispartof><rights>2017 The Author(s)</rights><rights>Copyright © 2017 The Author(s). Published by Elsevier B.V. All rights reserved.</rights><rights>Copyright Elsevier Science Ltd. Oct 2017</rights><rights>2017 The Author(s) 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c483t-b565845ec506d41f39e82edcb6a5ca5369870f87366a91c91023303bb1015cf53</citedby><cites>FETCH-LOGICAL-c483t-b565845ec506d41f39e82edcb6a5ca5369870f87366a91c91023303bb1015cf53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1382668917302016$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28843101$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cooke, Andrew S.</creatorcontrib><creatorcontrib>Morgan, Eric R.</creatorcontrib><creatorcontrib>Dungait, Jennifer A.J.</creatorcontrib><title>Modelling the impact of targeted anthelmintic treatment of cattle on dung fauna</title><title>Environmental toxicology and pharmacology</title><addtitle>Environ Toxicol Pharmacol</addtitle><description>•Assessment of the impact of anthelmintic targeted selected treatment on invertebrates.•Practical risk matrix to assess the impact of treatment programs.•Novel approach to life cycle modelling of invertebrates.•Targeted selective treatment mitigates ecological impact of anthelmintics via refugia.
The insecticidal properties of many anthelmintics pose a risk to dung fauna through the effects of drug residues in dung on the activity, oviposition and development of dung-dwelling invertebrates. Reductions in dung fauna numbers can inhibit dung degradation, which may impact biodiversity and nutrient cycling on farms. A simulation model was created to predict the impact of antiparasitic drugs on cattle dung fauna, and calibrated using published data on the dung-breeding fly Scathophaga stercoraria. This model was then tested under different effective dung drug concentrations (EC) and proportions of treated cattle (PT) to determine the impact under different application regimens. EC accounted for 12.9% of the observed variation in S. stercoraria population size, whilst PT accounted for 54.9%. The model outputs indicate that the tendency within veterinary medicine for targeted selective treatments (TST), in order to attenuate selection for drug resistance in parasite populations, will decrease the negative impacts of treatments on dung fauna populations by providing population refugia. This provides novel evidence for the benefits of TST regimens on local food webs, relative to whole-herd treatments. The model outputs were used to create a risk graph for stakeholders to use to estimate risk of anthelminthic toxicity to dung fauna.</description><subject>Agriculture</subject><subject>Animals</subject><subject>Anthelmintic agents</subject><subject>Anthelmintic resistance</subject><subject>Anthelmintics - adverse effects</subject><subject>Antiparasitic</subject><subject>Biodiversity</subject><subject>Bovidae</subject><subject>Cattle</subject><subject>Cattle manure</subject><subject>Computer simulation</subject><subject>Data processing</subject><subject>Diptera - drug effects</subject><subject>Diptera - growth & development</subject><subject>Drug resistance</subject><subject>Dung</subject><subject>Environment</subject><subject>Environmental Monitoring</subject><subject>Farms</subject><subject>Fauna</subject><subject>Feces - chemistry</subject><subject>Food chains</subject><subject>Food webs</subject><subject>Helminth</subject><subject>Insecticide resistance</subject><subject>Insecticides - adverse effects</subject><subject>Invertebrates</subject><subject>Livestock breeding</subject><subject>Model testing</subject><subject>Models, Chemical</subject><subject>Nutrient cycles</subject><subject>Oviposition</subject><subject>Parasites</subject><subject>Pesticide Residues</subject><subject>Population Density</subject><subject>Population number</subject><subject>Populations</subject><subject>Refugia</subject><subject>Risk</subject><subject>Scathophaga stercoraria</subject><subject>Targeted selective treatment</subject><subject>Toxicity</subject><subject>Veterinary medicine</subject><issn>1382-6689</issn><issn>1872-7077</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kV1rFTEQhoNYbK3-AS9kwRtv9jQfm48FEaT4BS290euQzc6e5rCbHJNswX_vHE8t6kVhIIF53peZeQl5xeiGUaYudhuobr_hlOkNxWL8CTljRvNWU62f4l8Y3ipl-lPyvJQdpUwKYZ6RU25MJ9DjjNxcpxHmOcRtU2-hCcve-dqkqakub6HC2LiIjXkJsQbf1AyuLhB_I97VOkOTYjOuqJ_cGt0LcjK5ucDL-_ecfP_08dvll_bq5vPXyw9Xre-MqO0glTSdBC-pGjs2iR4Mh9EPyknvpFC90XQyWijleuZ7RrkQVAwDDi39JMU5eX_03a_DgkIcKbvZ7nNYXP5pkwv2304Mt3ab7qxUQuN50ODtvUFOP1Yo1S6heDyFi5DWYlkvuOmUoj2ib_5Dd2nNEdeznAqpue5EhxQ_Uj6nUjJMD8Mwag952Z095GUPeVmKxTiKXv-9xoPkT0AIvDsCgMe8C5Bt8QGihzFk8NWOKTzm_wvMmaad</recordid><startdate>201710</startdate><enddate>201710</enddate><creator>Cooke, Andrew S.</creator><creator>Morgan, Eric R.</creator><creator>Dungait, Jennifer A.J.</creator><general>Elsevier B.V</general><general>Elsevier Science Ltd</general><general>Elsevier Science B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7ST</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope><scope>SOI</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201710</creationdate><title>Modelling the impact of targeted anthelmintic treatment of cattle on dung fauna</title><author>Cooke, Andrew S. ; Morgan, Eric R. ; Dungait, Jennifer A.J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-b565845ec506d41f39e82edcb6a5ca5369870f87366a91c91023303bb1015cf53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Agriculture</topic><topic>Animals</topic><topic>Anthelmintic agents</topic><topic>Anthelmintic resistance</topic><topic>Anthelmintics - adverse effects</topic><topic>Antiparasitic</topic><topic>Biodiversity</topic><topic>Bovidae</topic><topic>Cattle</topic><topic>Cattle manure</topic><topic>Computer simulation</topic><topic>Data processing</topic><topic>Diptera - drug effects</topic><topic>Diptera - growth & development</topic><topic>Drug resistance</topic><topic>Dung</topic><topic>Environment</topic><topic>Environmental Monitoring</topic><topic>Farms</topic><topic>Fauna</topic><topic>Feces - chemistry</topic><topic>Food chains</topic><topic>Food webs</topic><topic>Helminth</topic><topic>Insecticide resistance</topic><topic>Insecticides - adverse effects</topic><topic>Invertebrates</topic><topic>Livestock breeding</topic><topic>Model testing</topic><topic>Models, Chemical</topic><topic>Nutrient cycles</topic><topic>Oviposition</topic><topic>Parasites</topic><topic>Pesticide Residues</topic><topic>Population Density</topic><topic>Population number</topic><topic>Populations</topic><topic>Refugia</topic><topic>Risk</topic><topic>Scathophaga stercoraria</topic><topic>Targeted selective treatment</topic><topic>Toxicity</topic><topic>Veterinary medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cooke, Andrew S.</creatorcontrib><creatorcontrib>Morgan, Eric R.</creatorcontrib><creatorcontrib>Dungait, Jennifer A.J.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Environment Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Environment Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Environmental toxicology and pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cooke, Andrew S.</au><au>Morgan, Eric R.</au><au>Dungait, Jennifer A.J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Modelling the impact of targeted anthelmintic treatment of cattle on dung fauna</atitle><jtitle>Environmental toxicology and pharmacology</jtitle><addtitle>Environ Toxicol Pharmacol</addtitle><date>2017-10</date><risdate>2017</risdate><volume>55</volume><spage>94</spage><epage>98</epage><pages>94-98</pages><issn>1382-6689</issn><eissn>1872-7077</eissn><abstract>•Assessment of the impact of anthelmintic targeted selected treatment on invertebrates.•Practical risk matrix to assess the impact of treatment programs.•Novel approach to life cycle modelling of invertebrates.•Targeted selective treatment mitigates ecological impact of anthelmintics via refugia.
The insecticidal properties of many anthelmintics pose a risk to dung fauna through the effects of drug residues in dung on the activity, oviposition and development of dung-dwelling invertebrates. Reductions in dung fauna numbers can inhibit dung degradation, which may impact biodiversity and nutrient cycling on farms. A simulation model was created to predict the impact of antiparasitic drugs on cattle dung fauna, and calibrated using published data on the dung-breeding fly Scathophaga stercoraria. This model was then tested under different effective dung drug concentrations (EC) and proportions of treated cattle (PT) to determine the impact under different application regimens. EC accounted for 12.9% of the observed variation in S. stercoraria population size, whilst PT accounted for 54.9%. The model outputs indicate that the tendency within veterinary medicine for targeted selective treatments (TST), in order to attenuate selection for drug resistance in parasite populations, will decrease the negative impacts of treatments on dung fauna populations by providing population refugia. This provides novel evidence for the benefits of TST regimens on local food webs, relative to whole-herd treatments. The model outputs were used to create a risk graph for stakeholders to use to estimate risk of anthelminthic toxicity to dung fauna.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>28843101</pmid><doi>10.1016/j.etap.2017.07.012</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Agriculture Animals Anthelmintic agents Anthelmintic resistance Anthelmintics - adverse effects Antiparasitic Biodiversity Bovidae Cattle Cattle manure Computer simulation Data processing Diptera - drug effects Diptera - growth & development Drug resistance Dung Environment Environmental Monitoring Farms Fauna Feces - chemistry Food chains Food webs Helminth Insecticide resistance Insecticides - adverse effects Invertebrates Livestock breeding Model testing Models, Chemical Nutrient cycles Oviposition Parasites Pesticide Residues Population Density Population number Populations Refugia Risk Scathophaga stercoraria Targeted selective treatment Toxicity Veterinary medicine |
| title | Modelling the impact of targeted anthelmintic treatment of cattle on dung fauna |
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