Revealing complete complex KIR haplotypes phased by long-read sequencing technology

The killer cell immunoglobulin-like receptor (KIR) region of human chromosome 19 contains up to 16 genes for natural killer (NK) cell receptors that recognize human leukocyte antigen (HLA)/peptide complexes and other ligands. The KIR proteins fulfill functional roles in infections, pregnancy, autoim...

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Veröffentlicht in:	Genes and immunity 2017-09, Vol.18 (3), p.127-134
Hauptverfasser:	Roe, D, Vierra-Green, C, Pyo, C-W, Eng, K, Hall, R, Kuang, R, Spellman, S, Ranade, S, Geraghty, D E, Maiers, M
Format:	Artikel
Sprache:	eng
Schlagworte:	45/23 631/208/728 631/250/248 Alleles Autoimmune diseases Biomedical and Life Sciences Biomedicine Cancer Research Cell receptors Chromosome 19 Chromosomes, Human, Pair 19 - genetics Clonal deletion DNA sequencing Evolutionary genetics Gene deletion Gene Expression Gene fusion Genes Genetic aspects Genomes Haplotypes Health aspects Histocompatibility antigen HLA Human Genetics Humans Immunology Insertion Killer cell immunoglobulin-like receptors Killer cells Natural killer cells Original original-article Physiological aspects Pregnancy Receptors, KIR - genetics Recombination Transplantation Whole Genome Sequencing - methods
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